Abstract：OBJECTIVE: To study the clinical significance of serum levels of insulin-like growth factor 1 (IGF-1) and insulin-like growth factor binding protein 3 (IGFBP-3) in children with Henoch-Schonlein purpura (HSP) or Henoch-Schonlein purpura nephritis (HSPN). METHODS: Thirty-one children with HSP were selected as the HSP group, and 28 children with HSPN were selected as the HSPN group. Another 31 healthy children were selected as the control group. ELISA was used to measure serum levels of IGF-1 and IGFBP-3 in each group. Measurement of 24-hour urinary protein excretion was performed using an automatic biochemical analyzer in the HSPN group. Serum immunoglobulin (Ig) levels, complement C3 level and complete blood counts in each group were determined, and urine analysis was also performed. RESULTS: Serum levels of IGF-1 and IGFBP-3 in the HSP group were significantly higher than in the control group (P<0.05), and serum levels of IGF-1 and IGFBP-3 in the HSPN group were significantly higher than in the HSP and control groups (P<0.05). Among 12 children who underwent renal puncture biopsy, patients with higher pathological grades had higher serum levels of IGF-1 and IGFBP-3. In children with HSPN, those with proteinuria had significantly higher serum levels of IGF-1 and IGFBP-3 than those without proteinuria (P<0.05). Levels of white cells, red cells, platelet count, complement C3, IgG, and IgA and IgA/C3 ratio were significantly higher in the HSP and HSPN groups than in the control group (P<0.05). CONCLUSIONS: Increased serum levels of IGF-1 and IGFBP-3 are observed in the acute onset period of HSP, which may be related to the degree of proteinuria and renal damage. Serum levels of IGF-1 and IGFBP-3 may be indicators of renal involvement
RU Liang,Abulaiti Abudouhaer,GUO Yan-Fang. Clinical significance of serum levels of IGF-1 and IGFBP-3 in children with Henoch-Schonlein purpura or Henoch-Schonlein purpura nephritis[J]. CJCP, 2013, 15(11): 1009-1013.
Law HK, Tu W, Liu E, Lau YL．Insulin-like growth factor-I promotes cord blood Tcell maturationtlmugh Inonocytes and inhibits their apoptosis in part through interleukin-6[J]．BMC Immunol, 2008, 17(9): 74.
[9]
Bideci A, Camurdan MO, Cinaz P, Dursun H, Demirel F. Serum zinc, insulin-like growth factor-I and insulin-like growth factor binding protein-3 levels in children with type 1 diabetes mellitus[J]. J Pediatr Endocrinol Metab, 2005, 18(10): 1007-1011.
[10]
Akturk M, Arslan M, Altinova A, Ozdemir A, Ersoy R, Yetkin I, et al. Association of serum levels of IGF-1and IGFBP-1 with renal function in patients with type 2 diabetes mellitus[J]. Growth Horm IGF Res, 2007, 17(3): 186-193.
[11]
Xi G, Hathaway MR, White ME, Dayton WR. Localization of insulin-like growth factor (IGFBP)-3 in cultured porcine embryonic myogenic cells before and after TGF-beta1 treatment[J]. Domest Anim Endocrinol, 2007, 33(4): 422-429.
[12]
Glaser S, Friedrich N, Ewert R, Schaper C, Nauck M, Dorr M, et al. Association between serum IGF-I and IGFBP-3 and lung function[J]. J Clin Endocrinol Metab, 2009, 94(7): 2452-2458.
[13]
Rosendahl AH, Forsberg G. IGF-I and IGFBP-3 augment transforming growth factor-beta actions in human renal carcinoma cells[J]. Kidney Int, 2006, 70(9): 1584-1590.
[14]
Haghshenas Z, Sotoudeh K, Karamifar H, Karamizadeh Z, Amirhakimi G. The role of insulin like growth factor (IGF)-1 and IGF-binding protein-3 in diagnosis of Growth Hormone Deficiency in short stature children[J]. Indian J Pediatr, 2009, 76(7): 699-703.
[15]
Balaram SK, Agrawal DK, Edward JD. Insulin like growth factor-1 activates nuclear factor-κB and increases transcription of the intercellular adhesion molecule gene in endothelial cells[J]. Cardiovasc Surg, 1999, 7(1): 91-97.
[16]
Jafar TH, Stark PC, Schmid CH, Landa M, Mascantoni C, de Zeeuw D. Proteinuria as amodiffiable risk factor for progression of non-diabetic renal disease[J]. Kidney Int, 2001, 60(3): 1131-1140.
[17]
Tonshoff B, Kaskel FJ, Moore LC. Effects of insulin-like growth factorⅠon the renal juxtamedullary microvasculature[J]. Am J Physiol, 1998, 274(1 Pt 2): F120-F128.
[18]
Shin JI, Park JM, Shin YH, Lee JS, Jeong HJ, Kim HS. Serum IgA/C3 ratio may be a useful marker of disease activity in severe Henoch-schonlein nephritis[J]. Nephron Clin Pract, 2005, 101(2): 72-78.
