Abstract：Objective To study the utility of fractional exhaled nitric oxide (FeNO) in young children at different stages of asthma. Methods Fifty-eight children with newly diagnosed asthma (aged 1-3 years) at the acute exacerbation stage between April and June, 2014 were recruited. After 3 months' treatment, the children switched into the chronic persistent stage (n=34) or remission stage (n=24). Thirty aged-matched healthy children served as controls. FeNO levels and lung function were measured for all subjects. The best cut-off value of FeNO for the diagnosis of asthma was evaluated by receiver operating characteristic (ROC) curve. Results The FeNO levels in children with asthma at various stages were higher than controls (PPr=-0.382, PConclusions The children with asthma at different stages have different FeNO levels. Measurement of FeNO is useful in the diagnosis of asthma in young children.
Gustafsson LE, Leone AM, Persson MG, et al. Endogenous nitric oxide is present in the exhaled air of rabbits, guinea pigs and humans[J]. Biochem Biophys Respir Commun, 1991, 181(2): 852-857.
[2]
Cobos Barroso N, Pérez-Yarza EG, Sardón Prado O, et al. Exhaled nitric oxide in children: a noninvasive marker of airway inflammation[J]. Arch Bronconeumol, 2008, 44(1): 4151.
American Thoracic Society; European Respiratory Society. ATS/ERS recommendations for standardized procedures for the online and offline measurement of exhaled lower respiratory nitric oxide and nasal nitric oxide, 2005[J]. Am J Respir Crit Care Med, 2005, 171(8): 912-930.
Dweik RA, Boggs PB, Erzurum SC, et al. An official ATS clinical practice guideline: interpretation of exhaled nitirc oxide levels(FENO) for clinical applications[J]. Am J Respir Crict Care Med, 2011, 184(5): 602-615.
Douwes J, Gibson P, Pekkanen J, et al. Non-eosinophilic asthma: importance and possible mechanisms[J]. Thorax, 2005, 57(7): 643-648.
[10]
Kelekci S, Sen V, Yolbas I, et al. FeNO levels in children with asthma and other diseases of the lung[J]. Eur Rev Med Pharmacol Sci, 2013, 17(22): 3078-3082.
[11]
Sonnappa S, Bastardo CW, Stafler P, et al. Ethnic differences infraction of exhaled nitric oxide and lunfunction in haethy young childre[J]. Chest, 2011, 140(5): 1325-1331.
[12]
Kovesi T, Kuika R, Dales R. Exhaled nitric oxide concentration is affected by age, height, and race in healthy 9 to 12-year-old children[J]. Chest, 2008, 133(1): 169-175.
[13]
Zhang H, Shu L, Cai X, et al. Gender and age affect the levels of exhaled nitric oxide in healthy children[J]. Exp Ter Med, 2013, 5(4): 1174-1178.
[14]
Buchvald F, Baraldi E, Carraro S, et al. Measurements of exhaled nitric oxide in healthy subjects age 4 to 17 years[J]. J Allergy Clin Immunol, 2005, 115(6): 1130-1136.
[15]
Liu HC, Hsu JY, Cheng YW, et al. Exhaled nitric oxide in a Taiwanese population: age and lung function as predicting factors[J]. J Formos Med Assoc, 2009, 108(10): 772-777.
[16]
Latzin P, Beck J, Griese M. Exhaled nitric oxide in healthy children:variability and a lack of correlation with atopy[J]. Pediatr Allergy Immunol, 2002, 13(1): 37-46.
[17]
Bjermer L, Alving K, Diamant Z, et al. Current evidence and future research needs for FeNO measurement in respiratory diseases[J]. Respir Med, 2014, 108(6): 830-841.
[18]
Olin AC, Bake B, Toren K. Fraction of exhaled nitric oxide at 50 mL/s: reference values for adult lifelong never smokers[J]. Chest, 2007, 131(6): 1852-1856.
[19]
Taylor DPI, Mandhane P, Greene JM, et al. Factors affecting exhaled nitric oxide measurements: the effect of sex[J]. Respir Res, 2007, 8: 82.
[20]
Ludviksdottir D, Diamant Z, Alving K, et al. Clinical aspects of using exhaled NO in asthma diagnosis and management[J]. Clin Respir J, 2012, 6(4): 193-207.
[21]
Hylke H, Marianne L, Franka H, et al. Reference value of exhaled nitric oxide in healthy children 1-5 years using off-line tidal breathing[J]. Pediatr Pulmonol, 2014, 49(3): 291-295.
