Abstract：The etiology and pathogenic mechanism of autism spectrum disorders(ASD) are still unclear.The relationship between vitamin D and ASD has drawn attention in recent years due to common vitamin D deficiency in children with ASD.This article reviews the peripheral blood levels of vitamin D in children with ASD, the possible reasons for hypovitamin D and its possible roles in the etiology of ASD and the efficacy of vitamin D supplementation in ASD.
Smith IM, Koegel RL, Koegel LK, et al. Effectiveness of a novel community-based early intervention model for children with autistic spectrum disorder[J]. Am J Intellect Dev Disabil, 2010, 115(6):504-523.
[3]
Gutstein SE. Empowering families through relationship development intervention:an important part of the biopsychosocial management of autism spectrum disorders[J]. Ann Clin Psychiatry, 2009, 21(3):174-182.
[4]
Baker E, Jeste SS. Diagnosis and management of autism spectrum disorder in the era of genomics:rare disorders can pave the way for targeted treatments[J]. Pediatr Clin North Am, 2015, 62(3):607-618.
[5]
Currenti SA. Understanding and determining the etiology of autism[J]. Cell Mol Neurobiol, 2010, 30(2):161-171.
[6]
Muhle R, Trentacoste SV, Rapin I. The genetics of autism[J]. Pediatrics, 2004, 113(5):e472-e486.
[7]
Eyles D, Brown J, Mackay-Sim A, et al. Vitamin D3 and brain development[J]. Neuroscience, 2003, 118(3):641-653.
[8]
Kalueff AV, Minasyan A, Keisala T, et al. The vitamin D neuroendocrine system as a target for novel neurotropic drugs[J]. CNS Neurol Disord Drug Targets, 2006, 5(3):363-572.
[9]
Eyles DW, Burne TH, McGrath JJ. Vitamin D, effects on brain development, adult brain function and the links between low levels of vitamin D and neuropsychiatric disease[J]. Front Neuroendocrinol, 2013, 34(1):47-64.
Kanner L. Autistic disturbances of affective contact[J]. Acta Paedopsychiatr, 1968, 35(4):100-136.
[12]
Developmental Disabilities Monitoring Network Surveillance Year 2010 Principal Investigators; Centers for Disease Control and Prevention(CDC). Prevalence of autism spectrum disorder among children aged 8 years-autism and developmental disabilities monitoring network, 11 sites, United States, 2010[J]. MMWR Surveill Summ, 2014, 63(2):1-21.
[13]
Lu Z, Chen TC, Zhang A, et al. An evaluation of the vitamin D3 content in fish:Is the vitamin D content adequate to satisfy the dietary requirement for vitamin D[J]. J Steroid Biochem Mol Biol, 2007, 103(3-5):642-644.
[14]
Trilok-Kumar G, Kaur M, Rehman AM, et al. Effects of vitamin D supplementation in infancy on growth, bone parameters, body composition and gross motor development at age 3-6 years:follow-up of a randomized controlled trial[J]. Int J Epidemiol, 2015, 44(3):894-905.
[15]
Saggese G, Vierucci F, Boot AM, et al. Vitamin D in childhood and adolescence:an expert position statement[J]. Eur J Pediatr, 2015, 174(5):565-576.
[16]
Kesby JP, Eyles DW, Burne TH, et al. The effects of vitamin D on brain development and adult brain function[J]. Mol Cell Endocrinol, 2011, 347(1-2):121-127.
[17]
Eyles D, Burne T, McGrath J. Vitamin D in fetal brain development[J]. Semin Cell Dev Biol, 2011, 22(6):629-636.
[18]
Harms LR, Burne TH, Eyles DW, et al. Vitamin D and the brain[J]. Best Pract Res Clin Endocrinol Metab, 2011, 25(4):657-669.
[19]
Shirazi HA, Rasouli J, Ciric B, et al. 1,25-Dihydroxy vitamin D3 enhances neural stem cell proliferation and oligodendrocyte differentiation[J]. Exp Mol Pathol, 2015, 98(2):240-245.
[20]
Kočovská E, Fernell E, Billstedt E, et al. Vitamin D and autism:clinical review[J]. Res Dev Disabil, 2012, 33(5):1541-1550.
[21]
Bohnsaek BL, Hirschi KK. Nutrient regulation of cell cycle progression[J]. Annu Rev Nutr, 2004, 24(10):433-453.
[22]
Cui X, McGrath JJ, Burne TH, et al. Maternal vitamin D depletion alters neurogenesis in the developing rat brain[J]. Int J Dev Neurosci, 2007, 25(4):227-232.
[23]
Samuel S, Sitrin MD. Vitamin D's role in cell proliferation and differentiation[J]. Nutr Rev, 2008, 66(10 Suppl 2):S116-S124.
[24]
Kesby JP, Cui X, O'Loan J, et al. Developmental vitamin D deficiency alters dopamine-mediated behaviors and dopamine transporter function in adult female rats[J]. Psychopharmacology(Berl), 2010, 208(1):159-168.
[25]
Cannell JJ. Autism and vitamin D[J]. Med Hypotheses, 2008, 70(4):750-759.
[26]
Meguid NA, Hashish AF, Anwar M, et al. Reduced serum levels of 25-hydroxy and 1,25-dihydroxy vitamin D in Egyptian children with autism[J]. J Altern Complement Med, 2010, 16(6):641-645.
[27]
Mostafa GA, Al-Ayadhi LY. Reduced serum concentrations of 25-hydroxy vitamin D in children with autism:relation to autoimmunity[J]. J Neuroinflammation, 2012, 9:201.
[28]
Tostes MH, Polonini HC, Gattaz WF, et al. Low serum levels of 25-hydroxyvitamin D(25-OHD) in children with autism[J]. Trends Psychiatry Psychother, 2012, 34(3):161-163.
[29]
Neumeyer AM, Gates A, Ferrone C, et al. Bone density in peripubertal boys with autism spectrum disorders[J]. J Autism Dev Disord, 2013, 43(7):1623-1629.
[30]
Gong ZL, Luo CM, Wang L, et al. Serum 25-hydroxyvitamin D levels in Chinese children with autism spectrum disorders[J]. Neuroreport, 2014, 25(1):23-27.
[31]
Bener A, Khattab AO, Al-Dabbagh MM. Is high prevalence of Vitamin D deficiency evidence for autism disorder?:In a highly endogamous population[J]. J Pediatr Neurosci, 2014, 9(3):227-233.
Saad K, Abdel-Rahman AA, Elserogy YM, et al. Vitamin D status in autism spectrum disorders and the efficacy of vitamin D supplementation in autistic children[J]. Nutr Neurosci, 2015[Epub ahead of print]. PMID:25876214.
[34]
Fernell E, Bejero S, Westerlund J, et al. Autism spectrum disorder and low vitamin D at birth:a sibling control study[J]. Mol Autism, 2015, 6(1):1-9.
[35]
Adams JB, Audhya T, McDonough-Means S, et al. Nutritional and metabolic status of children with autism vs. neurotypical children, and the association with autism severity[J]. Nutr Metab, 2011, 8(1):34-65.
[36]
Ugur C, Gurkan CK. Serum vitamin D and folate levels in children with autism spectrum disorders[J]. Res Autism Spect Dis, 2014, 8(12):1641-1647.
[37]
Azzam HME, Sayyah H, Youssef S, et al. Autism and vitamin D:an intervention study[J]. Middle East Current Psychiatry, 2015, 22(1):9-14.
[38]
Qiu HM, Yang JX, Liu D, et al. Antidepressive effect of sodium valproate involving suppression of corticotropin-releasing factor expression and elevation of BDNF expression in rats exposed to chronic unpredicted stress[J]. Neuroreport, 2014, 25(4):205-210.
[39]
Shinnar S, Cnaan A, Hu F, et al. Long-term outcomes of generalized tonic-clonic seizures in a childhood absence epilepsy trial[J]. Neurology, 2015, 85(13):1108-1114.
[40]
Harit D, Aggarwal A, Kalra S, et al. Effect of carbamazepine and valproate monotherapy on cardiovascular risks in epileptic children[J]. Pediatr Neurol, 2015, 53(1):88-90.
[41]
Wood AG, Nadebaum C, Anderson V, et al. Prospective assessment of autism traits in children exposed to antiepileptic drugs during pregnancy[J]. Epilepsia, 2015, 56(7):1047-1055.
[42]
Christensen J, Grønborg TK, Sørensen MJ, et al. Prenatal valproate exposure and risk of autism spectrum disorders and childhood autism[J]. Obst Gynecol Survey, 2013, 68(9):613-614.
[43]
Bromley RL, Mawer GE, Briggs M, et al. The prevalence of neurodevelopmental disorders in children prenatally exposed to antiepileptic drugs[J]. J Neurol Neurosurg Psychiatry, 2013, 84(6):637-643.
[44]
Ahn Y, Narous M, Tobias R, et al. The ketogenic diet modifies social and metabolic alterations identified in the prenatal valproic acid model of autism spectrum disorder[J]. Dev Neurosci, 2014, 36(5):371-380.
[45]
Kim KC, Kim P, Go HS, et al. Male-specific alteration in excitatory post-synaptic development and social interaction in prenatal valproic acid exposure model of autism spectrum disorder[J]. J Neurochem, 2013, 124(6):832-843.
[46]
Selim ME, Al-Ayadhi LY. Possible ameliorative effect of breastfeeding and the uptake of human colostrum against coeliac disease in autistic rats[J]. World J Gastroenterol, 2013, 19(21):3281-3290.
[47]
Vrzal R, Doricakova A, Novotna A, et al. Valproic acid augments vitamin D receptor-mediated induction of CYP24 by vitamin D3:a possible cause of valproic acid-induced osteomalacia?[J]. Toxicol Lett, 2011, 200(3):146-153.
[48]
Schmidt RJ, Hansen RL, Hartiala J, et al. Selected vitamin D metabolic gene variants and risk for autism spectrum disorder in the CHARGE Study[J]. Early Hum Dev, 2015, 91(8):483-489.
[49]
Grant WB, Soles CM. Epidemiologic evidence supporting the role of maternal vitamin D deficiency as a risk factor for the development of infantile autism[J]. Dermatoendocrinol, 2009, 1(4):223-228.
[50]
Bakare MO, Munir KM. Autism spectrum disorders(ASD) in Africa:a perspective[J]. Afr J Psychiatry, 2011, 14(3):208-210.
[51]
Atladottir HO, Parner ET, Schendel D, et al. Time trends in reported diagnoses of childhood neuropsychiatric disorders:a Danish cohort study[J]. Arch Pediatr Adolesc Med, 2007, 161(2):193-198.
[52]
El-Ansary A, Al-Ayadhi L. Relative abundance of short chain and polyunsaturated fatty acids in propionic acid-induced autistic features in rat pups as potential markers in autism[J]. Lipids Health Dis, 2014, 13:140-149.
[53]
Alfawaz HA, Bhat RS, Al-Ayadhi L, et al. Protective and restorative potency of Vitamin D on persistent biochemical autistic features induced in propionic acid-intoxicated rat pups[J]. BMC Complement Altern Med, 2014, 14(1):416-425.
[54]
Jia F, Wang B, Shan L, et al. Core symptoms of autism improved after vitamin D supplementation[J]. Pediatrics, 2015, 135(1):e196-e198.
Masi A, Quintana DS, Glozier N, et al. Cytokine aberrations in autism spectrum disorder:a systematic review and metaanalysis[J]. Mol Psychiatry, 2015, 20(4):440-446.
[57]
Golla S, Sweeney JA. Corticosteroid therapy in regressive autism:Preliminary findings from a retrospective study[J]. BMC Med, 2014, 12:79.
[58]
James SJ, Melnyk S, Jernigan S, et al. Metabolic endophenotype and related genotypes are associated with oxidative stress in children with autism[J]. Am J Med Genet B Neuropsychiatr Genet, 2006, 141B(8):947-956.
[59]
Harrington RA, Lee LC, Crum RM, et al. Serotonin hypothesis of autism:implications for selective serotonin reuptake inhibitor use during pregnancy[J]. Autism Res, 2013, 6(3):149-168.
[60]
Chugani DC, Muzik O, Behen M, et al. Developmental changes in brain serotonin synthesis capacity in autistic and nonautistic children[J]. Ann Neurol, 1999, 45(3):287-295.
[61]
Hoppman-Chaney N, Wain K, Seger PR, et al. Identification of single gene deletions at 15q13.3:further evidence that CHRNA7 causes the 15q13.3 microdeletion syndrome phenotype[J]. Clin Genet, 2013, 83(4):345-351.
[62]
Iossifov I, O'Roak BJ, Sanders SJ, et al. The contribution of de novo coding mutations to autism spectrum disorder[J]. Nature, 2014, 515(7526):216-221.
[63]
De Rubeis S, He X, Goldberg AP, et al. Synaptic, transcriptional and chromatin genes disrupted in autism[J]. Nature, 2014, 515(7526):209-215.
[64]
Munoz LE, Schiller M, Zhao Y, et al. Do low vitamin D levels cause problems of waste removal in patients with SLE?[J]. Rheumatology(Oxford), 2012, 51(4):585-587.
[65]
Adorini L, Penna G. Control of autoimmune diseases by the vitamin D endocrine system[J]. Nat Clin Pract Rheumatol, 2008, 4(8):404-412.
[66]
Prietl B, Pilz S, Wolf M, et al. Vitamin D supplementation and regulatory T cells in apparently healthy subjects:vitamin D treatment for autoimmune diseases?[J]. Isr Med Assoc J, 2010, 12(3):136-139.
[67]
Guillot X, Semerano L, Saidenberg-Kermanac'h N, et al. Vitamin D and inflammation[J]. Joint Bone Spine, 2010, 77(6):552-557.
[68]
Garcion E, Thanh XD, Bled F, et al. 1,25-Dihydroxyvitamin D3 regulates gamma 1 transpeptidase activity in rat brain[J]. Neurosci Lett, 1996, 216(3):183-186.
[69]
Halicka HD, Zhao H, Li J, et al. Attenuation of constitutive DNA damage signaling by 1,25-dihydroxyvitamin D3[J]. Aging(Albany NY), 2012, 4(4):270-278.
[70]
Crockett MJ, Clark L, Tabibnia G, et al. Serotonin modulates behavioral reactions to unfairness[J]. Science, 2008, 320(5884):1739-1741.
[71]
Patrick RP, Ames BN. Vitamin D hormone regulates serotonin synthesis. Part 1:relevance for autism[J]. FASEB J, 2014, 28(6):2398-2413.
[72]
Neale BM, Kou Y, Liu L, et al. Patterns and rates of exonic de novo mutations in autism spectrum disorders[J]. Nature, 2012, 485(7397):242-245.
[73]
Fleet JC, DeSmet M, Johnson R, et al. Vitamin D and cancer:a review of molecular mechanisms[J]. Biochem J, 2012, 441(1):61-76.
[74]
Fedirko V, Bostick RM, Long Q, et al. Effects of supplemental vitamin D and calcium on oxidative DNA damage marker in normal colorectal mucosa:a randomized clinical trial[J]. Cancer Epidemiol Biomarkers Prev, 2010, 19(1):280-291.
[75]
Smith DC, Johnson CS, Freeman CC, et al. A Phase I trial of calcitriol(1,25-dihydroxycholecalciferol) in patients with advanced malignancy[J]. Clin Cancer Res, 1999, 5(6):1339-1345.
[76]
Fedirko V, Bostick RM, Flanders WD, et al. Effects of vitamin D and calcium supplementation on markers of apoptosis in normal colon mucosa:a randomized, double-blind, placebo-controlled clinical trial[J]. Cancer Prev Res(Phila), 2009, 2(3):213-223.
