糖水缓解1~12月婴儿预防接种所致疼痛效果的系统评价

谌绍林; Harrison Denise; 黄瑞瑞; 张晴; 谢日华; 文师吾

doi:10.7499/j.issn.1008-8830.2016.06.013

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中国当代儿科杂志 ›› 2016, Vol. 18 ›› Issue (6) : 534-540. DOI: 10.7499/j.issn.1008-8830.2016.06.013

论著·临床研究

糖水缓解1~12月婴儿预防接种所致疼痛效果的系统评价

谌绍林¹, Harrison Denise², 黄瑞瑞¹, 张晴¹, 谢日华^1,3, 文师吾⁴

作者信息 +

Efficacy of sweet solutions in relieving pain caused by vaccination in infants aged 1 to 12 months: a systematic review

CHEN Shao-Lin¹, Harrison Denise², HUANG Rui-Rui¹, ZHANG Qing¹, XIE Ri-Hua^1,3, WEN Shi-Wu⁴

Author information +

文章历史 +

摘要

目的评价口服糖水对缓解1~12月婴儿预防接种所致疼痛的效果,为临床实践提供依据。方法通过计算机检索数据库,纳入相关随机对照试验(RCTs)文献;评价其研究质量、提取资料;采用Revman 5.3软件行Meta分析。结果共纳入20项RCTs (n = 2 376),有6项质量评价为A级,14项为B级。Meta分析显示,与无菌水相比,口服25%~75%糖水降低了婴儿啼哭时间 [WMD = -21.16,95%CI(-39.66,-2.77),P < 0.05]、啼哭时间比例 (啼哭时间/注射开始后3 min) [WMD = -13.83,95%CI(-20.88,-6.78),P < 0.01];而口服12%蔗糖水组与无干预组相比,婴儿啼哭持续时间无统计学差异。结论预防接种前2 min,口服25%~75%糖水2 mL可有效缓解1~12月婴儿预防接种所致疼痛。

Abstract

Objective To investigate the efficacy of oral sweet solutions in relieving pain caused by vaccination in infants aged 1 to 12 months. Methods Related databases were searched to find related randomized control trails (RCTs). The quality of these RCTs was evaluated. The Meta analysis was performed using RevMan 5.3. Results A total of 20 RCTs involving 2 376 infants were included, and quality assessment showed that 6 RCTs had grade A quality and 14 had grade B quality. The Meta analysis showed that compared with sterile water, 25%-75% oral sweet solution significantly reduced crying time (WMD = -21.16, 95%CI -39.66 to -2.77, P < 0.05) and the proportion of crying time (the duration of crying /3-minute periods after the injection) (WMD = -13.83, 95%CI -20.88 to -6.78, P < 0.01), while the crying time showed no significant difference between the group treated with oral administration of 12% sucrose solution and non-intervention group. Conclusions Oral sweet solution (25%-75%; 2 mL) given 2 minutes before vaccination can effectively relieve the pain caused by vaccination in infants aged 1-12 months.

导出引用

谌绍林, Harrison Denise, 黄瑞瑞, 张晴, 谢日华, 文师吾. 糖水缓解1~12月婴儿预防接种所致疼痛效果的系统评价[J]. 中国当代儿科杂志. 2016, 18(6): 534-540 https://doi.org/10.7499/j.issn.1008-8830.2016.06.013

CHEN Shao-Lin, Harrison Denise, HUANG Rui-Rui, ZHANG Qing, XIE Ri-Hua, WEN Shi-Wu. Efficacy of sweet solutions in relieving pain caused by vaccination in infants aged 1 to 12 months: a systematic review[J]. Chinese Journal of Contemporary Pediatrics. 2016, 18(6): 534-540 https://doi.org/10.7499/j.issn.1008-8830.2016.06.013

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