Research advances in breast milk-acquired cytomegalovirus infection in premature infants
RAN Li-Hong, BAO Lei
Department of Neonatology, Children's Hospital of Chongqing Medical University, China International Science and Technology Cooperation Base of Child Development and Critical Disorders/Chongqing Key Laboratory of Pediatrics, Chongqing 400014, China
Abstract：Breast milk is considered ideal food for premature infants, but it can also be the main source of cytomegalovirus (CMV) infection in premature infants. CMV infection may cause serious clinical symptoms, such as sepsis-like syndrome, thrombocytopenia, neutropenia, jaundice, hepatitis, and pneumonitis. This article reviews the research advances in symptoms, treatment strategies, prognosis and the prevention of breast milk-acquired CMV infection in premature infants
Carling S, Demment MM, Kjolhede CL, et al. Breastfeeding duration and weight gain trajectory in infancy[J]. Pediatrics, 2015, 135(1): 111-119.
[3]
Yamakawa M, Yorifuji T, Inoue S, et al. Breastfeeding and obesity among schoolchildren: a nationwide longitudinal survey in Japan[J]. JAMA Pediatr, 2013, 167(10): 919-925.
[4]
Bergström A, Skov TH, Bahl MI, et al. Establishment of intestinal microbiota during early life: a longitudinal, explorative study of a large cohort of Danish infants[J]. Appl Environ Microbiol, 2014, 80(9): 2889-2900.
[5]
Underwood MA, Gaerlan S, De Leoz ML, et al. Human milk oligosaccharides in premature infants: absorption, excretion, and influence on the intestinal microbiota[J]. Pediatr Res, 2015, 78(6): 670-677.
[6]
Zhou J, Shukla VV, John D, et al. Human milk feeding as a protective factor for retinopathy of prematurity: a metaanalysis[ J]. Pediatrics, 2015, 136(6): e1576-e1586.
[7]
Josephson CD, Caliendo AM, Easley KA, et al. Blood transfusion and breast milk transmission of cytomegalovirus in very low-birth-weight infants: a prospective cohort study[J]. JAMA Pediatr, 2014, 168(11): 1054-1062.
Álvarez Domínguez E, Figueras Aloy J, Botet Mussons F, et al. Screening for cytomegalovirus infection in very low birth weight infants[J]. An Pediatr (Barc), 2013, 79(1): 3-9.
Kurath S, Halwachs-Baumann G, Müller W, et al. Transmission of cytomegalovirus via breast milk to the prematurely born infant: a systematic review[J]. Clin Microbiol Infect, 2010, 16(8): 1172-1178.
[14]
Arellano-Galindo J, Villanueva-García D, Cruz-Ramirez JL, et al. Detection and gB genotyping of CMV in Mexican preterm infants in the context of maternal seropositivity[J]. J Infect Dev Ctries, 2014, 8(6): 758-767.
[15]
Ehlinger EP, Webster EM, Kang HH, et al. Maternal cytomegalovirus-specific immune responses and symptomatic postnatal cytomegalovirus transmission in very low-birth-weight preterm infants[J]. J Infect Dis, 2011, 204(11): 1672-1682.
[16]
Gunkel J, Wolfs TF, de Vries LS, et al. Predictors of severity for postnatal cytomegalovirus infection in preterm infants and implications for treatment[J]. Expert Rev Anti Infect Ther, 2014, 12(11): 1345-1355.
[17]
Kurath S, Halwachs-Baumann G, Müller W, et al. Transmission of cytomegalovirus via breast milk to the prematurely born infant: a systematic review[J]. Clin Microbiol Infect, 2010, 16(8): 1172-1178.
[18]
Alarcón Allen A, Baquero-Artigao F; Grupo de estudio de la infección por citomegalovirus de la Sociedad Española de Infectología Pediátrica. Review and guidelines on the prevention, diagnosis and treatment of post-natal cytomegalovirus infection[J]. An Pediatr (Barc), 2011, 74(1): 52.e1-52.e13.
[19]
Nijman J, de Vries LS, Koopman-Esseboom C, et al. Postnatally acquired cytomegalovirus infection in preterm infants: a prospective study on risk factors and cranial ultrasound findings[J]. Arch Dis Child Fetal Neonatal Ed, 2012, 97(4): 259-263.
[20]
Mehler K, Oberthuer A, Lang-Roth R, et al. High rate of symptomatic cytomegalovirus infection in extremely low gestational age preterm infants of 22-24 weeks' gestation after transmission via breast milk[J]. Neonatology, 2014, 105(1): 27-32.
[21]
Tengsupakul S, Birge ND, Bendel CM, et al. Asymptomatic DNAemia heralds CMV-associated NEC: case report, review, and rationale for preemption[J]. Pediatrics, 2013, 132(5): e1428-e1434.
[22]
Takahashi R, Tagawa M, Sanjo M, et al. Severe postnatal cytomegalovirus infection in a very premature infant[J]. Neonatology, 2007, 92(4): 236-239.
[23]
Neuberger P, Hamprecht K, Vochem M, et al. Case-control study of symptoms and neonatal outcome of human milk-transmitted cytomegalovirus infection in premature infants[J]. J Pediatr, 2006, 148(3): 326-331.
[24]
Kimberlin DW, Jester PM, Sánchez PJ, et al. Valganciclovir for symptomatic congenital cytomegalovirus disease[J]. N Engl J Med, 2015, 372(10): 933-943.
[25]
Jim WT, Chiu NC, Ho CS, et al. Outcome of preterm infants with postnatal cytomegalovirus infection via breast milk: a twoyear prospective follow-up study[J]. Medicine (Baltimore), 2015, 94(43): e1835.
[26]
Goelz R, Meisner C, Bevot A, et al. Long-term cognitive and neurological outcome of preterm infants with postnatally acquired CMV infection through breast milk[J]. Arch Dis Child Fetal Neonatal Ed, 2013, 98(5): 430-433.
[27]
Yoo HS, Sung SI, Jung YJ, et al. Prevention of cytomegalovirus transmission via breast milk in extremely low birth weight infants[J]. Yonsei Med J, 2015, 56(4): 998-1006.
[28]
Lanzieri TM, Dollard SC, Josephson CD, et al. Breast milkacquired cytomegalovirus infection and disease in VLBW and premature infants[J]. Pediatrics, 2013, 131(6): 1937-1945.
[29]
Chiavarini M, Bragetti P, Sensini A. Breastfeeding and transmission of cytomegalovirus to preterm infants. Case report and kinetic of CMV-DNA in breast milk[J]. Ital J Pediatr, 2011, 37: 6.
[30]
Hayashi S, Kimura H, Oshiro M, et al. Transmission of cytomegalovirus via breast milk in extremely premature infants[J]. J Perinatol, 2011, 31(6): 440-445.
[31]
Omarsdottir S, Casper C, Navér L, et al. Cytomegalovirus infection and neonatal outcome in extremely preterm infants after freezing of maternal milk[J]. Pediatr Infect Dis J, 2015, 34(5): 482-489.
[32]
Gomes FP, Shaw PN, Whitfield K, et al. Effect of pasteurisation on the concentrations of vitamin D compounds in donor breastmilk[J]. Int J Food Sci Nutr, 2016, 67(1): 16-19.
Meier PP, Engstrom JL, Patel AL, et al. Improving the use of human milk during and after the NICU stay[J]. Clin Perinatol, 2010, 73(1): 217-245.
[35]
Dempsey AF, Pangborn HM, Prosser LA. Cost-effectiveness of routine vaccination of adolescent females against cytomegalovirus[J]. Vaccine, 2012, 30(27): 4060-4066.
[36]
Nigro G, Capretti I, Manganello AM, et al. Primary maternal cytomegalovirus infections during pregnancy: association of CMV hyperimmune globulin with gestational age at birth and birth weight[J]. J Matern Fetal Neonatal Med, 2015, 28(2): 168-171.
[37]
Revello MG, Lazzarotto T, Guerra B, et al. A randomized trial of hyperimmune globulin to prevent congenital cytomegalovirus[J]. N Engl J Med, 2014, 370(14): 1316-1326.
