Abstract：Long non-coding RNAs (lncRNAs) are transcripts with a complex structure and a length of > 200 nt which are unable to encode proteins. The lncRNAs interact with DNA, mRNA, and proteins and regulate gene expression through various mechanisms, thus participating in the regulation of various biological processes. Studies have shown that lncRNAs play important roles in neural development and the pathogenesis of diseases. This article reviews the roles of lncRNAs in hypoxic-ischemic brain damage.
Li J,Zhang M,An G,et al.LncRNA TUG1 acts as a tumor suppressor in human glioma by promoting cell apoptosis[J].Exp Biol Med (Maywood),2016,241(6):644-649.
[2]
Zhang M,Gu H,Xu W,et al.Downregulation of lncRNA MALAT1 reduces cardiomyocyte apoptosis and improves left ventricular function in diabetic rats[J].Int J Cardiol,2016,203:214-216.
[3]
Wu H,Liu J,Li W,et al.LncRNA-HOTAIR promotes TNFalpha production in cardiomyocytes of LPS-induced sepsis mice by activating NF-kappa B pathway[J].Biochem Biophys Res Commun,2016,471(1):240-246.
[4]
Wang Y,Wu P,Lin R,et al.LncRNA NALT interaction with NOTCH1 promoted cell proliferation in pediatric T cell acute lymphoblastic leukemia[J].Sci Rep,2015,5:13749.
[5]
Shi X,Sun M,Liu H,et al.Long non-coding RNAs:a new frontier in the study of human diseases[J].Cancer Lett,2013,339(2):159-166.
[6]
Goff LA,Groff AF,Sauvageau M,et al.Spatiotemporal expression and transcriptional perturbations by long noncoding RNAs in the mouse brain[J].Proc Natl Acad Sci U S A,2015,112(22):6855-6862.
[7]
Aprea J,Prenninger S,Dori M,et al.Transcriptome sequencing during mouse brain development identifies long non-coding RNAs functionally involved in neurogenic commitment[J].EMBO J,2013,32(24):3145-3160.
[8]
Luo H,Sun S,Li P,et al.Comprehensive characterization of 10571 mouse large intergenic noncoding RNAs from whole transcriptome sequencing[J].PLoS One,2013,8(8):e70835.
[9]
Cabili MN,Trapnell C,Goff L,et al.Integrative annotation of human large intergenic noncoding RNAs reveals global properties and specific subclasses[J].Genes Dev,2011,25(18):1915-1927.
Zhao F,Qu Y,Liu J,et al.Microarray profiling and coexpression network analysis of lncRNAs and mRNAs in neonatal rats following hypoxic-ischemic brain damage[J].Sci Rep,2015,5(3):370-371.
[12]
Ng SY,Lin L,Son BS,et al.Long noncoding RNAs in development and disease of the central nervous system[J].Trends Genet,2013,29(8):461-468.
[13]
Zequn N,Xuemei Z,Wei L,et al.The role and potential mechanisms of LncRNA-TATDN1 on metastasis and invasion of non-small cell lung cancer[J].Oncotarget,2016,7(14):18219-18228.
[14]
Liu JY,Yao J,Li XM,et al.Pathogenic role of lncRNAMALAT1 in endothelial cell dysfunction in diabetes mellitus[J].Cell Death Dis,2014,5:e1506.
[15]
Massone S,Vassallo I,Fiorino G,et al.17A,a novel non-coding RNA,regulates GABA B alternative splicing and signaling in response to inflammatory stimuli and in Alzheimer disease[J].Neurobiol Dis,2011,41(2):308-317.
[16]
Dharap A,Nakka VP,Vemuganti R.Effect of focal ischemia on long noncoding RNAs[J].Stroke,2012,43(10):2800-2802.
[17]
Liu H,Song G,Zhou L,et al.Compared analysis of lncRNA expression profiling in pdk1 gene knockout mice at two time points[J].Cell Physiol Biochem,2013,32(5):1497-1508.
[18]
Zheng B,Liu H,Wang R,et al.Expression signatures of long non-coding RNAs in early brain injury following experimental subarachnoid hemorrhage[J].Mol Med Rep,2015,12(1):967-973.
[19]
Dharap A,Pokrzywa C,Vemuganti R.Increased binding of stroke-induced long non-coding RNAs to the transcriptional corepressors Sin3A and coREST[J].ASN Neuro,2013,5(4):283-289.
[20]
Mehta SL,Kim T,Vemuganti R.Long noncoding RNA FosDT promotes ischemic brain injury by interacting with RESTassociated chromatin-modifying proteins[J].J Neurosci,2015,35(50):16443-16449.
[21]
Puyal J,Vaslin A,Mottier V,et al.Postischemic treatment of neonatal cerebral ischemia should target autophagy[J].Ann Neurol,2009,66(3):378-389.
[22]
Zhao G,Zhang W,Li L,et al.Pinocembrin protects the brain against ischemia-reperfusion injury and reverses the autophagy dysfunction in the penumbra area[J].Molecules,2014,19(10):15786-15798.
[23]
Carloni S,Girelli S,Scopa C,et al.Activation of autophagy and Akt/CREB signaling play an equivalent role in the neuroprotective effect of rapamycin in neonatal hypoxiaischemia[J].Autophagy,2010,6(3):366-377.
[24]
Carloni S,Albertini MC,Galluzzi L,et al.Increased autophagy reduces endoplasmic reticulum stress after neonatal hypoxiaischemia:role of protein synthesis and autophagic pathways[J].Exp Neurol,2014,255:103-112.
[25]
Gao C,Cai Y,Zhang X,et al.Ischemic preconditioning mediates neuroprotection against ischemia in mouse hippocampal CA1 neurons by inducing autophagy[J].PLoS One,2015,10(9):e0137146.
[26]
Ordoñez R,Fernández A,Prieto-Domínguez N,et al.Ceramide metabolism regulates autophagy and apoptotic cell death induced by melatonin in liver cancer cells[J].J Pineal Res,2015.59(2):178-189.
[27]
Wang K,Liu CY,Zhou LY,et al.APF lncRNA regulates autophagy and myocardial infarction by targeting miR-188-3p[J].Nat Commun,2015,6:6779.
[28]
Chen CL,Tseng YW,Wu JC,et al.Suppression of hepatocellular carcinoma by baculovirus-mediated expression of long non-coding RNA PTENP1 and MicroRNA regulation[J].Biomaterials,2015,44:71-81.
[29]
Kernie SG,Parent JM.Forebrain neurogenesis after focal Ischemic and traumatic brain injury[J].Neurobiol Dis,2010,37(2):267-274.
[30]
Komitova M,Mattsson B,Johansson BB,et al.Enriched environment increases neural stem/progenitor cell proliferation and neurogenesis in the subventricular zone of stroke-lesioned adult rats[J].Stroke,2005.36(6):1278-1282.
[31]
Kojima T,Hirota Y,Ema M,et al.Subventricular zone-derived neural progenitor cells migrate along a blood vessel scaffold toward the post-stroke striatum[J].Stem Cells,2010,28(3):545-554.
[32]
Ramos AD,Diaz A,Nellore A,et al.Integration of genomewide approaches identifies lncRNAs of adult neural stem cells and their progeny in vivo[J].Cell Stem Cell,2013,12(5):616-628.
[33]
Ramos AD,Andersen RE,Liu SJ,et al.The long noncoding RNA Pnky regulates neuronal differentiation of embryonic and postnatal neural stem cells[J].Cell Stem Cell,2015,16(4):439-447.
[34]
Makeyev EV,Zhang J,Carrasco MA,et al.The MicroRNA miR-124 promotes neuronal differentiation by triggering brainspecific alternative pre-mRNA splicing[J].Mol Cell,2007,27(3):435-448.
[35]
Ferrarese R,Harsh GR 4th,Yadav AK,et al.Lineage-specific splicing of a brain-enriched alternative exon promotes glioblastoma progression[J].J Clin Invest,2014,124(7):2861-2876.
[36]
Xue Y,Ouyang K,Huang J,et al.Direct conversion of fibroblasts to neurons by reprogramming PTB-regulated microRNA circuits[J].Cell,2013,152(1-2):82-96.
[37]
Zeng L,Wang Y,Liu J,et al.Pro-inflammatory cytokine network in peripheral inflammation response to cerebral ischemia[J].Neurosci Lett,2013,548:4-9.
[38]
Rapicavoli NA,Qu K,Zhang J,et al.A mammalian pseudogene lncRNA at the interface of inflammation and anti-inflammatory therapeutics[J].Elife,2013,2:e00762.
[39]
Cui H,Xie N,Tan Z,et al.The human long noncoding RNA lnc-IL7R regulates the inflammatory response[J].Eur J Immunol,2014,44(7):2085-2095.
[40]
Ruparelia AA,Oorschot V,Ramm G,et al.FLNC myofibrillar myopathy results from impaired autophagy and protein insufficiency[J].Hum Mol Genet,2016,Mar 11.pii:ddw080.
[41]
Zhang J,Yuan L,Zhang X,et al.Altered long non-coding RNA transcriptomic profiles in brain microvascular endothelium after cerebral ischemia[J].Exp Neurol,2015,277:162-170.
