Abstract：Objective To investigate the clinical features and prognosis of acute renal failure (ARF) caused by rhabdomyolysis (RM) in children. Methods A retrospective analysis was performed for the clinical data, laboratory examination, and prognosis of 26 RM children with ARF. Results The causes for all 26 RM children with ARF were non-traumatic diseases, and the three most common causes were infection (69%), diabetes (12%), and metabolic disease (8%). In the RM children with ARF, the five most frequent clinical manifestations were fever (69%), multiple organ dysfunction syndrome (69%), convulsion (46%), oliguria or anuria (35%), and tea-colored urine (27%). All 26 children had a serum creatine kinase (CK) level of >1 000 IU/L, among whom 26 had increased aspartate aminotransferase, 25 had increased alanine aminotransferase, 25 had increased creatine kinase isoenzyme, and 23 had increased lactate dehydrogenase. Serum myoglobin (Mb) was measured in 22 children and was found to increase in all these children. The mean time for CK to decrease to below 1 000 IU/L was 10±5 d. There was no significant difference in the time to CK recovery between the 10 children who were treated with conventional treatment as well as continuous venous-venous hemofiltration and those who were not treated with blood purification (P > 0.05). Of all 26 RM children with ARF, 7 were withdrawn from the treatment, and 19 had normal renal function after treatment. Conclusions ARF and multiple organ dysfunction syndrome are major complications in RM children. The major primary disease for RM children with ARF is infectious disease. CK is the major marker for the diagnosis of RM. Early diagnosis and appropriate treatment may reverse ARF and improve prognosis.
MENG Fan-Ying,LIU Xiao-Rong,FU Qian et al. Acute renal failure caused by rhabdomyolysis in children: a clinical analysis of 26 cases[J]. CJCP, 2017, 19(2): 193-197.
Topcu Y,Bayram E,Karaoğlu P,et al.Carnitine palmitoy transferase Ⅱ deficiency in an adolescent presenting with rhabdomyolysis and acute renal failure[J].Pediatr Emerg Care, 2014,30(5):343-344.
Brown CV,Rhee P,Chan L,et al.Preventing renal failure in patients with rhabdomyolysis:do bicarbonate and mannitol make a difference[J].J Trauma,2004,56(6):1191-1196.
[25]
El-Abdellati E,Eyselbergs M,Sirimsi H,et al.An observational study on rhabdomyolysis in the intensive care unit.Exploring its risk factors and main complication:acute kidney injury[J].Ann Intensive Care,2013,3(1):8.
