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儿童重症腺病毒肺炎不良预后的危险因素分析
Risk factors for poor prognosis in children with severe adenovirus pneumonia
目的 探讨儿童重症腺病毒肺炎不良预后的危险因素。方法 回顾性分析189例重症腺病毒肺炎患儿的临床资料，通过单因素logistic回归分析评估预后不良的危险因素。结果 单因素logistic回归分析显示，血红蛋白 < 90g/L、白蛋白 < 30g/L、C-反应蛋白 > 30mg/L、降钙素原 > 10ng/mL、丙氨酸氨基转移酶 > 100U/L、天冬氨酸氨基转移酶 > 100U/L以及合并先天性气道发育异常、并发急性呼吸窘迫综合征、循环系统并发症、电解质酸碱平衡紊乱、并发3种及以上并发症者预后不良 （P < 0.05）。结论 重症腺病毒肺炎的不良预后与贫血、低白蛋白血症、炎症反应、并发多种并发症以及合并肺部基础疾病有关。
Objective To investigate the risk factors for poor prognosis of severe adenovirus pneumonia (SAP) in children. Methods The clinical data of 189 children with SAP were retrospectively analyzed. Univariate logistic regression analysis was performed to assess the risk factors for poor prognosis. Results The univariate logistic regression analysis showed that the patients with hemoglobin < 90 g/L, plasma albumin < 30 g/L, C-reactive protein > 30 mg/L, procalcitonin > 10 ng/mL, alanine aminotransferase > 100 U/L, or aspartate aminotransferase > 100 U/L had poor prognosis (P < 0.05), and that those with congenital dysplasia of the airway, acute respiratory distress syndrome, circulatory complications, electrolyte and acid-base disturbance, or more than three complications also had poor prognosis (P < 0.05). Conclusions Poor prognosis of severe adenovirus pneumonia in children is associated with anemia, low serum albumin, inflammatory response, concurrent multiple complications and underlying lung diseases.
Adenovirus / Severe pneumonia / Prognosis / Risk factor / Child
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