Abstract：Objective To investigate the distribution of adiponectin +45T/G and +276G/T polymorphisms and its association with the development of Kawasaki disease and coronary artery lesion (CAL).Methods A total of 81 children with Kawasaki disease (among whom 11 had CAL) and 100 normal children who underwent physical examination (control group) were enrolled in a case-control study. Sequencing was performed to investigate the distribution of adiponectin +45T/G and +276G/T polymorphisms.Results There were no significant differences between the Kawasaki disease and control groups in the frequencies of TT, TG, and GG genotypes and T/G alleles of +45T/G polymorphism in the adiponectin gene (P > 0.05). In the Kawasaki disease group, there were also no significant differences in the genotype and allele frequencies of the +45T/G polymorphism between the children with CAL and those without (P > 0.05). There were significant differences between the Kawasaki disease and control groups in the frequencies of GG, GT, and TT genotypes and G/T alleles of +276G/T polymorphism in the adiponectin gene (P < 0.05). GG genotype was a risk factor for the development of Kawasaki disease (OR=2.313, P=0.006). In the Kawasaki disease group, there was no significant difference in the genotype distribution of the +276G/T polymorphism between the children with CAL and those without (P > 0.05).Conclusions The adiponectin +276G/T polymorphism may be associated with the development of Kawasaki disease, but not associated with CAL. The adiponectin +45T/G polymorphism may not be associated with Kawasaki disease or CAL.
HUANG Miao,DONG Guo-Qing,XIAO Fei et al. Association of +45 and +276 polymorphisms in the adiponectin gene with the development of Kawasaki disease[J]. CJCP, 2018, 20(7): 549-553.
McCrindle BW, Rowley AH, Newburger JW, et al. Diagnosis, treatment, and long-term management of Kawasaki disease:a scientific statement for health professionals from the American Heart Association[J]. Circulation, 2017, 135(17):e927-e999.
[2]
Villarreal-Molina MT, Antuna-Puente B. Adiponectin:antiinflammatory and cardioprotective effects[J]. Biochimie, 2012, 94(10):2143-2149.
Denby KJ, Clark DE, Markham LW. Management of Kawasaki disease in adults[J]. Heart, 2017, 103(22):1760-1769.
[7]
Uehara R, Belay ED. Epidemiology of Kawasaki disease in Asia, Europe, and the United States[J]. J Epidemiol, 2012, 22(2):79-85.
[8]
Onouchi Y. The genetics of Kawasaki disease[J]. Int J Rheum Dis, 2017, 21(1):26-30.
[9]
Kim HJ, Choi EH, Kil HR. Association between adipokines and coronary artery lesions in children with Kawasaki disease[J]. J Korean Med Sci, 2014, 29(10):1385-1390.
[10]
Gupta AC, Misra R, Sakhuja P, et al. Association of adiponectin gene functional polymorphisms (-11377C/G and +45T/G) with nonalcoholic fatty liver disease[J]. Gene, 2012, 496(1):63-67.
[11]
Peters KE, Beilby J, Cadby G, et al. A comprehensive investigation of variants in genes encoding adiponectin (ADIPOQ) and its receptors (ADIPOR1/R2), and their association with serum adiponectin, type 2 diabetes, insulin resistance and the metabolic syndrome[J]. BMC Med Genet, 2013, 14:15.
[12]
Maintinguer Norde M, Oki É, de Castro IA, et al. Influence of adiponectin gene variants and plasma fatty acids on systemic inflammation state association-A cross-sectional population-based study, São Paulo, Brazil[J]. Mol Nutr Food Res, 2016, 60(2):278-286.
Zhan D, Thumtecho S, Tanavalee A, et al. Association of adiponectin gene polymorphisms with knee osteoarthritis[J]. World J Orthop, 2017, 8(9):719-725.
[15]
Rodríguez-Rodríguez L, García-Bermúdez M, González-Juanatey C, et al. Lack of association between ADIPOQ rs266729 and ADIPOQ rs1501299 polymorphisms and cardiovascular disease in rheumatoid arthritis patients[J]. Tissue Antigens, 2011, 77(1):74-78.
[16]
Daniels LB, Tjajadi MS, Walford HH, et al. Prevalence of Kawasaki disease in young adults with suspected myocardial ischemia[J]. Circulation, 2012, 125(20):2447-2453.
Zhang BC, Li WM, Xu YW. A meta-analysis of the association of adiponectin gene polymorphisms with coronary heart disease in Chinese Han population[J]. Clin Endocrinol (Oxf), 2012, 76(3):358-364.
[19]
Cheung CY, Hui EY, Cheung BM, et al. Adiponectin gene variants and the risk of coronary heart disease:a 16-year longitudinal study[J]. Eur J Endocrinol, 2014, 171(1):107-115.
[20]
Hou H, Ge S, Zhao L, et al. An updated systematic review and meta-analysis of association between adiponectin gene polymorphisms and coronary artery disease[J]. OMICS, 2017, 21(6):340-351.
