Abstract：Objective To study the clinical features and prognosis of bacterial meningitis in full-term and preterm infants. Methods A retrospective analysis was performed for the clinical data of 102 neonates with bacterial meningitis. According to the gestational age, they were divided into a preterm group (n=46) and a full-term group (n=56). The two groups were compared in terms of clinical manifestations, laboratory markers, imaging findings, and clinical outcomes. Results Poor response and apnea were the major clinical manifestations in the preterm group (P < 0.05), while pyrexia and convulsions were more common in the full-term group (P < 0.05). The full-term group had a significantly higher glucose level in cerebrospinal fluid (CSF) than the preterm group (P < 0.05). Compared with the full-term group, the preterm group had significantly higher C-reactive protein level, positive rate of blood culture, and incidence rate of poor prognosis (P < 0.05). There were no significant differences between the two groups in leukocyte count in peripheral blood, levels of leukocytes and protein in CSF, and positive rate of CSF culture (P > 0.05). Conclusions There are certain differences in the clinical manifestations between full-term and preterm infants with bacterial meningitis. Preterm infants tend to have a higher incidence rate of poor prognosis.
ZHAO Xiao-Lin,GUO Jin-Zhen,LI Zhan-Kui. A clinical analysis of bacterial meningitis in full-term and preterm infants[J]. CJCP, 2019, 21(10): 1044-1048.
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