儿童青少年心脏抑制型血管迷走性晕厥心电图P波的变化及诊断价值

王双双, 易秀英, 纪青, 王玉汶, 王成

中国当代儿科杂志 ›› 2019, Vol. 21 ›› Issue (11) : 1084-1088.

PDF(1220 KB)
HTML
PDF(1220 KB)
HTML
中国当代儿科杂志 ›› 2019, Vol. 21 ›› Issue (11) : 1084-1088. DOI: 10.7499/j.issn.1008-8830.2019.11.006
论著·临床研究

儿童青少年心脏抑制型血管迷走性晕厥心电图P波的变化及诊断价值

  • 王双双1,2, 易秀英2, 纪青2, 王玉汶1, 王成1
作者信息 +

Change in P wave on electrocardiogram and its diagnostic value in children and adolescents with cardioinhibitory vasovagal syncope

  • WANG Shuang-Shuang1,2, YI Xiu-Ying2, JI Qing2, WANG Yu-Wen1, WANG Cheng1
Author information +
文章历史 +

摘要

目的 探讨儿童青少年心脏抑制型血管迷走性晕厥(VVS-CI)心电图P波的变化及诊断价值。方法 选择43例明确诊断的VVS-CI儿童青少年为VVS-CI组,同期选取43例健康儿童青少年为对照组。测量两组基础状态下12导联心电图P波时限和电压,并分析其变化特点。结果 VVS-CI组心率低于对照组(P < 0.05),VVS-CI组P波时间(Pwd)、P波最大时间(Pmax)、P波离散度(Pd)、校正P波最大时间(Pcmax)、校正P波离散度(Pcd)较对照组延长(P < 0.05)。Pwd、Pmax、Pd、Pcmax、Pcd对儿童青少年VVS-CI有诊断价值(P < 0.05)。Pwd最佳截断值为78.49 ms,灵敏度为69.77%,特异度为83.72%;Pmax最佳截断值为93.39 ms,灵敏度为76.74%,特异度为90.70%;Pd最佳截断值为27.42 ms,灵敏度为95.35%,特异度为69.77%;Pcmax最佳截断值为120.90 ms,灵敏度为46.51%,特异度为88.37%;Pcd最佳截断值为36.37 ms,灵敏度为83.72%,特异度为72.09%。结论 儿童青少年VVS-CI的Pwd、Pmax、Pd、Pcmax、Pcd明显延长,提示可能存在心房电活动异常。P波界值对儿童青少年VVS-CI具有诊断价值。

Abstract

Objective To study the change in P wave on electrocardiogram and its diagnostic value in children and adolescents with cardioinhibitory vasovagal syncope (VVS-CI). Methods A total of 43 children and adolescents who were diagnosed with VVS-CI were enrolled as the VVS-CI group, and 43 healthy children and adolescents were enrolled as the control group. P wave duration and P wave voltage were measured by 12-lead electrocardiography in a basal state, and the changes were analyzed. Results Compared with the control group, the VVS-CI group had a significantly lower heart rate (P < 0.05) and significantly longer P wave duration (Pwd), P wave maximum duration (Pmax), and corrected P wave maximum duration (Pcmax), as well as significantly higher P wave dispersion (Pd) and corrected P wave dispersion (Pcd) (P < 0.05). Pwd, Pmax, Pd, Pcmax and Pcd had a certain diagnostic value in children and adolescents with VVS-CI (P < 0.05):Pwd had a sensitivity of 69.77% and a specificity of 83.72% at the optimal cut-off value of 78.49 ms; Pmax had a sensitivity of 76.74% and a specificity of 90.70% at the optimal cut-off value of 93.39 ms; Pd had a sensitivity of 95.35% and a specificity of 69.77% at the optimal cut-off value of 27.42 ms; Pcmax had a sensitivity of 46.51% and a specificity of 88.37% at the optimal cut-off value of 120.90 ms; Pcd had a sensitivity of 83.72% and a specificity of 72.09% at the optimal cut-off value of 36.37 ms. Conclusions Children and adolescents with VVS-CI have significantly increased Pwd, Pmax, Pd, Pcmax, and Pcd, which may indicate abnormal atrial electrical activity. The cut-off value of P wave has a certain diagnostic value in VVS-CI.

关键词

心脏抑制型血管迷走性晕厥 / 直立倾斜试验 / 心电描记术 / P波 / 儿童 / 青少年

Key words

Cardioinhibitory vasovagal syncope / Head-up tilt test / Electrocardiography / P wave / Child / Adolescent

引用本文

导出引用
王双双, 易秀英, 纪青, 王玉汶, 王成. 儿童青少年心脏抑制型血管迷走性晕厥心电图P波的变化及诊断价值[J]. 中国当代儿科杂志. 2019, 21(11): 1084-1088 https://doi.org/10.7499/j.issn.1008-8830.2019.11.006
WANG Shuang-Shuang, YI Xiu-Ying, JI Qing, WANG Yu-Wen, WANG Cheng. Change in P wave on electrocardiogram and its diagnostic value in children and adolescents with cardioinhibitory vasovagal syncope[J]. Chinese Journal of Contemporary Pediatrics. 2019, 21(11): 1084-1088 https://doi.org/10.7499/j.issn.1008-8830.2019.11.006

参考文献

[1] Wang C, Li Y, Liao Y, et al. 2018 Chinese Pediatric Cardiology Society (CPCS) guideline for diagnosis and treatment of syncope in children and adolescents[J]. Sci Bull, 2018, 63(23):1558-1564.
[2] Xu W, Wang T. Diagnosis and treatment of syncope in pediatric patients:a new guideline[J]. Sci Bull, 2019, 64(6):357-358.
[3] Pongiglione G, Fish FA, Strasburger JF, et al. Heart rate and blood pressure response to upright tilt in young patients with unexplained syncope[J]. J Am Coll Cardiol, 1990, 16(1):165-170.
[4] Chen L, Wang C, Wang H, et al. Underlying diseases in syncope of children in China[J]. Med Sci Monit, 2011, 17(6):PH49-PH53.
[5] 金红芳, 张凤文, 王成, 等. 儿童一过性意识丧失的基础疾病分析[J]. 中国小儿急救医学, 2012, 19(4):360-363.
[6] Paech C, Wagner F, Mensch S, et al. Cardiac pacing in cardioinhibitory syncope in children[J]. Congenit Heart Dis, 2018, 13(6):1064-1068.
[7] 杜军保, 王成. 儿童晕厥[M]. 北京:人民卫生出版社, 2011:171-176.
[8] 李雯, 王成, 吴礼嘉, 等. 直立倾斜试验阳性反应出现后的心律失常特征[J]. 中华心血管病杂志, 2010, 38(9):805-808.
[9] Chu W, Wang C, Lin P, et al. Transient aphasia:a rare complication of head-up tilt test[J]. Neurol Sci, 2014, 35(7):1127-1132.
[10] 王瑜丽, 张凤文, 李雪迎, 等. 儿童直立倾斜试验的倾斜角度探讨[J]. 实用儿科临床杂志, 2010, 25(13):980-982.
[11] Lin J, Wang Y, Ochs T, et al. Tilt angles and positive response of head-up tilt test in children with orthostatic intolerance[J]. Cardiol Young, 2015, 25(1):76-80.
[12] Magnani JW, Johnson VM, Sullivan LM, et al. P wave duration and risk of longitudinal atrial fibrillation in persons ≥ 60 years old (from the Framingham Heart Study)[J]. Am J Cardiol, 2011, 107(6):917-921. e1.
[13] Magnani JW, Mazzini MJ, Sullivan LM, et al. P-wave indices, distribution and quality control assessment (from the Framingham Heart Study)[J]. Ann Noninvasive Electrocardiol, 2010, 15(1):77-84.
[14] 曲秀芬. 自主神经对P波振幅和时限的影响[J]. 临床心电学杂志, 2006, 15(1):5-6.
[15] Sheldon RS, Grubb BP II, Olshansky B, et al. 2015 heart rhythm society expert consensus statement on the diagnosis and treatment of postural tachycardia syndrome, inappropriate sinus tachycardia, and vasovagal syncope[J]. Heart Rhythm, 2015, 12(6):e41-e63.
[16] Li J, Zhang Q, Hao H, et al. Clinical features and management of postural tachycardia syndrome in children:a single-center experience[J]. Chin Med J (Engl), 2014, 127(21):3684-3689.
[17] Stewart JM. A new guideline for diagnosis and treatment of syncope in children and adolescents that stimulates further thought and discussion[J]. Sci Bull (Beijing), 2018, 63(23):1527-1528.
[18] Chen L, Li X, Todd O, et al. A clinical manifestation-based prediction of haemodynamic patterns of orthostatic intolerance in children:a multi-centre study[J]. Cardiol Young, 2014, 24(4):649-653.
[19] Stewart JM, Boris JR, Chelimsky G, et al. Pediatric disorders of orthostatic intolerance[J]. Pediatrics, 2018, 141(1). pii:e20171673.
[20] Mosqueda-Garcia R, Furlan R, Tank J, et al. The elusive pathophysiology of neurally mediated syncope[J]. Circulation, 2000, 102(23):2898-2906.
[21] Dilaveris PE, Gialafos JE. P-wave dispersion:a novel predictor of paroxysmal atrial fibrillation[J]. Ann Noninvasive Electrocardiol, 2001, 6(2):159-165.
[22] Köse MD, Ba? Ö, Güven B, et al. P-wave dispersion:an indicator of cardiac autonomic dysfunction in children with neurocardiogenic syncope[J]. Pediatr Cardiol, 2014, 35(4):596-600.
[23] de Gregorio C, Lentini C, Grimaldi P, et al. P-wave voltage and peaking on electrocardiogram in patients undergoing head-up tilt testing for history of syncope[J]. Eur J Intern Med, 2014, 25(4):383-387.
[24] Lee DH, Lee KM, Yoon JM, et al. P wave dispersion on 12-lead electrocardiography in adolescents with neurocardiogenic syncope[J]. Korean J Pediatr, 2016, 59(11):451-455.
[25] Dilaveris PE, Gialafos EJ, Sideris SK, et al. Simple electrocardiographic markers for the prediction of paroxysmal idiopathic atrial fibrillation[J]. Am Heart J, 1998, 135(5 Pt 1):733-738.
[26] Conte G, Luca A, Yazdani S, et al. Usefulness of P-wave duration and morphologic variability to identify patients prone to paroxysmal atrial fibrillation[J]. Am J Cardiol, 2017, 119(2):275-279.
[27] Mugnai G, Chierchia GB, de Asmundis C, et al. P-wave indices as predictors of atrial fibrillation recurrence after pulmonary vein isolation in normal left atrial size[J]. J Cardiovasc Med (Hagerstown), 2016, 17(3):194-200.
[28] Mitro P, Kropuchová Z, Pella D, et al. Dynamic changes in the QT interval during the head-up tilt test in patients with vasovagal syncope[J]. Vnitr Lek, 2003, 49(1):27-31.


PDF(1220 KB)
HTML

Accesses

Citation

Detail

段落导航
相关文章

/