Clinical features of children with SARS-CoV-2 infection: an analysis of 115 cases
MA Yao-Ling1, XIA Sheng-Ying1, WANG Min1, ZHANG Si-Min1, DU Wen-Hui1, CHEN Qiong2
Department of Emergency, Wuhan Children's Hospital(Wuhan Maternal and Child Health Care Hospital), Tongji Medical College, Huazhong University of Science&Technology, Wuhan 430016, China
Abstract：Objective To study the clinical features of children with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Methods A retrospective analysis was performed for the clinical data of 115 children who were diagnosed with SARS-CoV-2 infection in the Wuhan Children's Hospital, including general information, history of close contact with individuals of SARS-CoV-2 infection, early clinical symptoms, laboratory examination results, and lung CT results. Results Among the 115 children, there were 73 boys (63.5%) and 42 girls (36.5%), with a male/ female ratio of 1:0.58. Of the 115 children, 105 (91.3%) had a definite history of close contact with individuals of SARSCoV-2-infection. An increase in alanine aminotransferase was observed in 11 children (9.6%) and an increase in CK-MB was found in 34 children (29.6%). As for clinical symptoms, 29 children (25.2%) had fever, 47 (40.9%) had respiratory symptoms (including cough, rhinorrhea, and nasal congestion), and 61 (53.0%) were asymptomatic. Lung CT findings showed ground glass opacity, fiber opacities, patchy changes, and pulmonary consolidation in 49 children (42.6%), among whom 2 children had “white lung”; 39 children (33.9%) only had lung texture enhancement and 27 children (23.5%) had no pulmonary imaging changes. Among the 115 children, 3 were critically ill, among whom 1 had been cured and the other 2 were under continuous treatment. Conclusions Most of the children with SARS-CoV-2 infection have a close contact history. Critical cases are rare and there is a high proportion of asymptomatic infection.
MA Yao-Ling,XIA Sheng-Ying,WANG Min et al. Clinical features of children with SARS-CoV-2 infection: an analysis of 115 cases[J]. CJCP, 2020, 22(4): 290-293.
Chen N, Zhou M, Dong X, et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China:a descriptive study[J]. Lancet, 2020, 395(10223):507-513.
[8]
Huang C, Wang Y, Li X, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China[J]. Lancet, 2020, 395(10223):497-506.
Chan JF, Yuan S, Kok KH, et al. A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating personto-person transmission:a study of a family cluster[J]. Lancet, 2020, 395(10223):514-523.
[12]
Huang C, Wang Y, Li X, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China[J]. Lancet, 2020, 395(10223):497-506.
[13]
Rahman A, Sarkar A. Risk factors for fatal Middle East respiratory syndrome coronavirus infections in Saudi Arabia:analysis of the WHO Line List, 2013-2018[J]. Am J Public Health, 2019, 109(9):1288-1293.
