B细胞淋巴增生性疾病中微小残留病检测的新进展

王妍, 文飞球

中国当代儿科杂志 ›› 2020, Vol. 22 ›› Issue (6) : 667-671.

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中国当代儿科杂志 ›› 2020, Vol. 22 ›› Issue (6) : 667-671. DOI: 10.7499/j.issn.1008-8830.1912034
综述

B细胞淋巴增生性疾病中微小残留病检测的新进展

  • 王妍, 文飞球
作者信息 +

Latest advances in minimal residual disease evaluation in B-cell lymphoproliferative disease

  • WANG Yan, WEN Fei-Qiu
Author information +
文章历史 +

摘要

在许多恶性血液系统疾病中,癌细胞清除率均与疾病预后息息相关。临床研究表明,微小残留病(MRD)可直接反映癌细胞清除率的高低,但目前用于MRD检测的工具仍有待完善。该综述介绍了数字聚合酶链反应和二代测序技术在B细胞淋巴增生性疾病MRD检测中的应用进展。

Abstract

The clearance of cancer cells is closely associated with the prognosis of various hematologic malignancies. Clinical studies have shown that minimal residual disease (MRD) can directly reflect the clearance of cancer cells, but the tools for MRD detection need to be improved. This article reviews the latest advances in the MRD detection by digital polymerase chain reaction and next-generation sequencing in B-cell lymphoproliferative disease.

关键词

微小残留病 / 数字聚合酶链反应 / 二代测序 / 液体活检 / 循环肿瘤基因

Key words

Minimal residual disease / Digital polymerase chain reaction / Next-generation sequencing / Liquid biopsy / Circulating tumor DNA

引用本文

导出引用
王妍, 文飞球. B细胞淋巴增生性疾病中微小残留病检测的新进展[J]. 中国当代儿科杂志. 2020, 22(6): 667-671 https://doi.org/10.7499/j.issn.1008-8830.1912034
WANG Yan, WEN Fei-Qiu. Latest advances in minimal residual disease evaluation in B-cell lymphoproliferative disease[J]. Chinese Journal of Contemporary Pediatrics. 2020, 22(6): 667-671 https://doi.org/10.7499/j.issn.1008-8830.1912034

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