糖皮质激素在川崎病治疗中的儿科专家共识

doi:10.7499/j.issn.1008-8830.2112033

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中国当代儿科杂志 ›› 2022, Vol. 24 ›› Issue (3) : 225-231. DOI: 10.7499/j.issn.1008-8830.2112033

标准·方案·指南

糖皮质激素在川崎病治疗中的儿科专家共识

陕西省川崎病诊疗中心/陕西省人民医院儿童病院；首都医科大学附属北京儿童医院；上海儿童医学中心；上海交通大学附属儿童医院；陕西省咸阳市儿童医院；苏州大学附属苏州儿童医院；重庆医科大学附属儿童医院；中国妇幼健康研究会儿科能力建设专家委员会；《中国当代儿科杂志》编辑部

作者信息 +

Pediatric expert consensus on the application of glucocorticoids in Kawasaki disease

Shaanxi Provincial Diagnosis and Treatment Center of Kawasaki Disease/Children's Hospital of Shaanxi Provincial People's Hospital; Beijing Children's Hospital, Capital Medical University; Shanghai Children's Medical Center; Children's Hospital of Shanghai Jiao Tong University; Xianyang Children's Hospital of Shaanxi Province; Suzhou Children's Hospital, Suzhou University; Children's Hospital of Chongqing Medical University; Expert Committee of Advanced Training for Pediatrician, China Maternal and Children's Health Association; Editorial Board of Chinese Journal of Contemporary Pediatrics

Author information +

文章历史 +

摘要

川崎病（Kawasaki disease，KD）是5岁以下儿童常见后天获得性心脏病之一，是一种急性自限性血管炎。经过近60年的研究，静脉注射免疫球蛋白联合阿司匹林口服成为急性期KD预防冠状动脉瘤的一线治疗。但对于发生冠状动脉瘤高风险、静脉注射免疫球蛋白无反应、确诊冠状动脉瘤等KD患者，糖皮质激素（glucocorticoid，GC）、英夫利昔单抗及其他免疫抑制剂是可以选择的治疗药物。目前GC在KD治疗中的应用存在争议。该共识结合KD治疗的国内外最新的研究成果，邀请国内儿科专家充分讨论，对GC在KD中一线及二线治疗的适应证、剂量、用法等提出了推荐意见。

Abstract

Kawasaki disease (KD) is one of the common acquired heart diseases in under-5-year-old children and is an acute self-limiting vasculitis. After nearly 60 years of research, intravenous immunoglobulin combined with oral aspirin has become the first-line treatment for preventing coronary artery aneurysm in the acute stage of KD. However, glucocorticoid (GC), infliximab, and other immunosuppressants are options for the treatment of KD patients with a high risk of coronary artery aneurysm, no response to intravenous immunoglobulin and a confirmed diagnosis of coronary artery aneurysm. At present, there are still controversies over the use of GC in the treatment of KD. With reference to the latest research findings of KD treatment in China and overseas, this consensus invited domestic pediatric experts to fully discuss and put forward recommendations on the indications, dosage, and usage of GC in the first-line and second-line treatment of KD.

导出引用

陕西省川崎病诊疗中心/陕西省人民医院儿童病院；首都医科大学附属北京儿童医院；上海儿童医学中心；上海交通大学附属儿童医院；陕西省咸阳市儿童医院；苏州大学附属苏州儿童医院；重庆医科大学附属儿童医院；中国妇幼健康研究会儿科能力建设专家委员会；《中国当代儿科杂志》编辑部. 糖皮质激素在川崎病治疗中的儿科专家共识[J]. 中国当代儿科杂志. 2022, 24(3): 225-231 https://doi.org/10.7499/j.issn.1008-8830.2112033

Shaanxi Provincial Diagnosis and Treatment Center of Kawasaki Disease/Children's Hospital of Shaanxi Provincial People's Hospital; Beijing Children's Hospital, Capital Medical University; Shanghai Children's Medical Center; Children's Hospital of Shanghai Jiao Tong University; Xianyang Children's Hospital of Shaanxi Province; Suzhou Children's Hospital, Suzhou University; Children's Hospital of Chongqing Medical University; Expert Committee of Advanced Training for Pediatrician, China Maternal and Children's Health Association; Editorial Board of Chinese Journal of Contemporary Pediatrics. Pediatric expert consensus on the application of glucocorticoids in Kawasaki disease[J]. Chinese Journal of Contemporary Pediatrics. 2022, 24(3): 225-231 https://doi.org/10.7499/j.issn.1008-8830.2112033

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