Abstract:Objective To investigate the changes in the rate and volume of mother's own milk (MOM) feeding for very low birth weight infants (VLBWIs) hospitalized during the prevention and control of the coronavirus disease 2019 (COVID-19) pandemic. Methods A retrospective analysis was performed on the medical data of the VLBWIs with a gestational age of <32 weeks who were born and admitted to the Neonatal Intensive Care Unit of Nanjing Maternal and Child Health Hospital from January 2019 to December 2020. The changes in the rate and volume of MOM feeding for VLBWIs during hospitalization were examined. Results A total of 301 VLBWIs were enrolled. According to the timing of COVID-19 outbreak, these infants were divided into a pre-CIVID-19 group with 205 VLBWIs and a post-COVID-19 group with 96 VLBWIs. Compared with the pre-CIVID-19 group, the post-COVID-19 group had a significantly lower rate of MOM feeding within 28 days after birth and during hospitalization (P<0.05), a significantly lower volume of MOM feeding within 0-7 days, 0-14 days, and 0-28 days after birth (P<0.05), and significantly higher incidence rates of moderate-to-severe bronchopulmonary dysplasia and feeding intolerance (P<0.05). Conclusions The COVID-19 pandemic has a significant impact on MOM feeding for VLBWIs, and there are significant reductions in the rate and volume of MOM feeding for VLBWIs within 28 days after birth, as well as a significant reduction in the rate of MOM feeding during hospitalization.
HU Xiao-Shan,ZHANG Min,JIANG Cheng-Yao et al. Influence of the coronavirus disease 2019 pandemic on maternal breastfeeding for very low birth weight infants[J]. CJCP, 2022, 24(6): 643-647.
5 Krogstad P, Contreras D, Ng H, et al. No evidence of infectious SARS-CoV-2 in human milk: analysis of a cohort of 110 lactating women[J]. medRxiv[Preprint]. (2021-04-07) [2022-01-01]. PMID: 33851178. PMCID: PMC8043475. DOI: 10.1101/2021.04.05.21254897.
Corpeleijn WE, Kouwenhoven SM, Paap MC, et al. Intake of own mother's milk during the first days of life is associated with decreased morbidity and mortality in very low birth weight infants during the first 60 days of life[J]. Neonatology, 2012, 102(4): 276-281. PMID: 22922675. DOI: 10.1159/000341335.
Williams JE, Price WJ, Shafii B, et al. Relationships among microbial communities, maternal cells, oligosaccharides, and macronutrients in human milk[J]. J Hum Lact, 2017, 33(3): 540-551. PMID: 28609134. DOI: 10.1177/0890334417709433.
Victora CG, Bahl R, Barros AJD, et al. Breastfeeding in the 21st century: epidemiology, mechanisms, and lifelong effect[J]. Lancet, 2016, 387(10017): 475-490. PMID: 26869575. DOI: 10.1016/S0140-6736(15)01024-7.
Fischer Fumeaux CJ, Garcia-Rodenas CL, De Castro CA, et al. Longitudinal analysis of macronutrient composition in preterm and term human milk: a prospective cohort study[J]. Nutrients, 2019, 11(7): 1525. PMID: 31277502. PMCID: PMC6683284. DOI: 10.3390/nu11071525.
H?rd AL, Nilsson AK, Lund AM, et al. Review shows that donor milk does not promote the growth and development of preterm infants as well as maternal milk[J]. Acta Paediatr, 2019, 108(6): 998-1007. PMID: 30565323. PMCID: PMC6520191. DOI: 10.1111/apa.14702.
Kirtsman M, Diambomba Y, Poutanen SM, et al. Probable congenital SARS-CoV-2 infection in a neonate born to a woman with active SARS-CoV-2 infection[J]. CMAJ, 2020, 192(24): E647-E650. PMID: 32409520. PMCID: PMC7828840. DOI: 10.1503/cmaj.200821.
Fan C, Lei D, Fang C, et al. Perinatal transmission of 2019 coronavirus disease-associated severe acute respiratory syndrome coronavirus 2: should we worry?[J]. Clin Infect Dis, 2021, 72(5): 862-864. PMID: 32182347. PMCID: PMC7184438. DOI: 10.1093/cid/ciaa226.
Pace RM, Williams JE, J?rvinen KM, et al. Milk from women diagnosed with COVID-19 does not contain SARS-CoV-2 RNA but has persistent levels of SARS-CoV-2-specific IgA antibodies[J]. Front Immunol, 2021, 12: 801797. PMID: 35003130. PMCID: PMC8733294. DOI: 10.3389/fimmu.2021.801797.
Pace RM, Williams JE, J?rvinen KM, et al. Characterization of SARS-CoV-2 RNA, antibodies, and neutralizing capacity in milk produced by women with COVID-19[J]. mBio, 2021, 12(1): e03192-20. PMID: 33563823. PMCID: PMC7885115. DOI: 10.1128/mBio.03192-20.
23 World Health Organization. Breastfeeding advice during COVID-19 outbreak[EB/OL]. [2022-01-10]. https://www.who.int/bangladesh/emergencies/coronavirus-disease-(covid-19)-update/breastfeeding.
Meinzen-Derr J, Poindexter B, Wrage L, et al. Role of human milk in extremely low birth weight infants' risk of necrotizing enterocolitis or death[J]. J Perinatol, 2009, 29(1): 57-62. PMID: 18716628. PMCID: PMC2801431. DOI: 10.1038/jp.2008.117.
Sisk PM, Lovelady CA, Dillard RG, et al. Early human milk feeding is associated with a lower risk of necrotizing enterocolitis in very low birth weight infants[J]. J Perinatol, 2007, 27(7): 428-433. PMID: 17443195. DOI: 10.1038/sj.jp.7211758.