Preadmission follow-up condition of neonates hospitalized due to severe hyperbilirubinemia after discharge from the department of obstetrics and influencing factors for follow-up compliance: a multicenter investigation
WANG Zeng-Qin, GAO Yan, DONG Xiao-Yue, WANG Huai-Yan, LU Hong-Yan, CHEN Xiao-Qing, XUE Mei, ZHANG Jia, WU Ming-Fu, WAN Jun, WU Xin-Ping, PAN Zhao-Jun, DENG Xiao-Yi, HAN Shu-Ping, QIAO Yu, YANG Li, YU Zhang-Bin
Department of Pediatrics, Women's Hospital of Nanjing Medical University, Nanjing 210004, China
Abstract：Objective To investigate the preadmission follow-up condition of neonates hospitalized due to severe hyperbilirubinemia after discharge from the department of obstetrics and the influencing factors for follow-up compliance. Methods A multicenter retrospective case-control study was performed for the cases from the multicenter clinical database of 12 units in the Quality Improvement Clinical Research Cooperative Group of Neonatal Severe Hyperbilirubinemia in Jiangsu Province of China from January 2019 to April 2021. According to whether the follow-up of neonatal jaundice was conducted on time after discharge from the department of obstetrics, the neonates were divided into two groups: good follow-up compliance and poor follow-up compliance. The multivariate logistic regression model was used to identify the influencing factors for follow-up compliance of the neonates before admission. Results A total of 545 neonates with severe hyperbilirubinemia were included in the study, with 156 neonates (28.6%) in the good follow-up compliance group and 389 (71.4%) in the poor follow-up compliance group. The multivariate logistic regression analysis showed that low gestational age at birth, ≥10% reduction in body weight on admission compared with birth weight, history of phototherapy of siblings, history of exchange transfusion of siblings, Rh(-) blood type of the mother, a higher educational level of the mother, the use of WeChat official account by medical staff to remind of follow-up before discharge from the department of obstetrics, and the method of telephone notification to remind of follow-up after discharge were associated with the increase in follow-up compliance (P<0.05). Conclusions Poor follow-up compliance is observed for the neonates with severe hyperbilirubinemia after discharge from the department of obstetrics, which suggests that it is necessary to further strengthen the education of jaundice to parents before discharge and improve the awareness of jaundice follow-up. It is recommended to remind parents to follow up on time by phone or WeChat official account.
WANG Zeng-Qin,GAO Yan,DONG Xiao-Yue et al. Preadmission follow-up condition of neonates hospitalized due to severe hyperbilirubinemia after discharge from the department of obstetrics and influencing factors for follow-up compliance: a multicenter investigation[J]. CJCP, 2022, 24(6): 669-674.
Shakib J, Buchi K, Smith E, et al. Timing of initial well-child visit and readmissions of newborns[J]. Pediatrics, 2015, 135(3): 469-474. PMID: 25647673. DOI: 10.1542/peds.2014-2329.
Li Q, Deng X, Yan J, et al. Neonatal severe hyperbilirubinemia online registry in Jiangsu province: protocol for a multicentre, prospective, open, observational cohort study[J]. BMJ Open, 2021, 11(2): e040797. PMID: 33550236. PMCID: PMC7925859. DOI: 10.1136/bmjopen-2020-040797.
American Academy of Pediatrics Subcommittee on Hyperbilirubinemia. Management of hyperbilirubinemia in the newborn infant 35 or more weeks of gestation[J]. Pediatrics, 2004, 114(1): 297-316. PMID: 15231951. DOI: 10.1542/peds.114.1.297.
Young PC, Korgenski K, Buchi KF. Early readmission of newborns in a large health care system[J]. Pediatrics, 2013, 131(5): e1538-e1544. PMID: 23569092. DOI: 10.1542/peds.2012-2634.
Johnson L, Bhutani VK, Karp K, et al. Clinical report from the pilot USA Kernicterus Registry (1992 to 2004)[J]. J Perinatol, 2009, 29 Suppl 1: S25-S45. PMID: 19177057. DOI: 10.1038/jp.2008.211.
Christensen RD, Agarwal AM, George TI, et al. Acute neonatal bilirubin encephalopathy in the State of Utah 2009-2018[J]. Blood Cells Mol Dis, 2018, 72: 10-13. PMID: 29880417. DOI: 10.1016/j.bcmd.2018.05.002.
Manning D, Todd P, Maxwell M, et al. Prospective surveillance study of severe hyperbilirubinaemia in the newborn in the UK and Ireland[J]. Arch Dis Child Fetal Neonatal Ed, 2007, 92(5): F342-F346. PMID: 17074786. PMCID: PMC2675352. DOI: 10.1136/adc.2006.105361.
