父亲生育年龄与儿童孤独症谱系障碍的相关性

doi:10.7499/j.issn.1008-8830.2203146

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摘要目的探讨父亲生育年龄与子代孤独症谱系障碍（autism spectrum disorder，ASD）的相关性。方法该研究为横断面研究，选取2016年8月至2017年3月在广州、佛山、北京、武汉、杭州、重庆的6家医院儿童保健科确诊的71例ASD儿童，以及年龄、性别和母亲生育年龄与ASD儿童匹配的284例正常发育儿童为研究对象。采用自编问卷调查收集社会人口学信息、母亲孕期及分娩等情况，采用logistic回归分析探讨父亲生育年龄与子代ASD发生的相关性。结果控制社会人口学因素、母亲孕期及分娩相关因素后，logistic回归分析显示较大的父亲生育年龄与子代患ASD风险增加显著相关（OR=1.12，95%CI：1.02~1.23，P<0.05）。将父亲生育年龄分组进一步分析，显示父亲生育年龄≥40岁与子代患ASD风险增加显著相关（调整前OR=7.08，95%CI：1.77~28.32，P<0.05；调整后OR=8.50，95%CI：1.71~42.25，P<0.05）。结论父亲生育年龄过大与子代患ASD风险升高显著相关，父亲生育年龄≥40岁为子代患ASD的高危年龄段。

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	潘宁
	林力孜
	王馨
	郭翠华
	静进
	李秀红

关键词 ：孤独症谱系障碍, 父亲生育年龄, 儿童

Abstract：Objective To study the association between paternal age at childbirth and the risk of autism spectrum disorder (ASD) in offspring. Methods In this cross-sectional study, 71 children with ASD who were diagnosed in the Department of Child Healthcare in six hospitals in Guangzhou, Foshan, Beijing, Wuhan, Hangzhou, and Chongqing of China from August 2016 to March 2017 were enrolled as subjects, and 284 typically developing children matched for age, sex, and maternal age at childbirth with the ASD children served as controls. A self-design questionnaire was used to collect the data on social demography, maternal pregnancy, and delivery. The association between paternal age at childbirth and the development of ASD in offspring was evaluated by the logistic regression analysis. Results After control for demographic factors and pregnancy- and delivery-related factors, the logistic regression analysis showed that a relatively high paternal age at childbirth was significantly associated with the increased risk of ASD in offspring (OR=1.12, 95%CI: 1.02-1.23, P<0.05). After grouping based on the paternal age, the logistic regression analysis showed that paternal age at childbirth of ≥40 years was significantly associated with the risk of ASD in offspring (before adjustment: OR=7.08, 95%CI: 1.77-28.32, P<0.05; after adjustment: OR=8.50, 95%CI: 1.71-42.25, P<0.05). Conclusions High paternal age at childbirth is significantly associated with the increased risk of ASD in offspring, and paternal age at childbirth ≥40 years may be the high-risk age group for ASD in offspring.

Key words： Autism spectrum disorder Paternal age at childbirth Child

收稿日期: 2022-03-25

基金资助:广东省重点领域研发计划项目（2019B030335001）；国家自然科学基金项目（81872639）。

通讯作者: 李秀红，女，教授，Email：lixh@mail.sysu.edu.cn E-mail: lixh@mail.sysu.edu.cn

作者简介: 潘宁，女，博士研究；

引用本文:

潘宁,林力孜,王馨等. 父亲生育年龄与儿童孤独症谱系障碍的相关性[J]. 中国当代儿科杂志, 2022, 24(8): 863-868.

PAN Ning,LIN Li-Zi,WANG Xin et al. Association between paternal age at childbirth and autism spectrum disorder in offspring[J]. CJCP, 2022, 24(8): 863-868.

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http://www.zgddek.com/CN/10.7499/j.issn.1008-8830.2203146 或 http://www.zgddek.com/CN/Y2022/V24/I8/863

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