新生儿缺血缺氧性脑病（hypoxic-ischemic encephalopathy，HIE）是一种新生儿较常见的影响脑功能的疾病。目前，亚低温、高压氧舱是治疗新生儿HIE的主要手段，然而二者互相独立，无法实现二者结合同步治疗，疗效单一，且未对新生儿进行脑功能相关的生理信息监测。此外，高压氧舱及亚低温床垫的参数设置依赖医疗师的经验，且在整个过程不变。该文提出了一种针对新生儿HIE治疗的新型装置，同时具有高压氧舱及亚低温床垫模块，使新生儿可以根据不同情况接受高压氧舱和/或亚低温床垫的治疗；还具有多种生理信息的实时监测功能，包括振幅整合脑电图、心电监护、近红外光谱监测，可以实时监测新生儿的脑功能状态、心率、心律、心肌供血、脑组织血红蛋白浓度和血氧饱和度；并且结合智能调控算法，根据新生儿的生理信息智能调控参数并提供后续治疗的建议。
Abstract
Neonatal hypoxic-ischemic encephalopathy (HIE) is a common disease that affects brain function in neonates. At present, mild hypothermia and hyperbaric oxygen therapy are the main methods for the treatment of neonatal HIE; however, they are independent of each other and cannot be combined for synchronous treatment, without monitoring of brain function-related physiological information. In addition, parameter setting of hyperbaric oxygen chamber and mild hypothermia mattress relies on the experience of the medical practitioner, and the parameters remain unchanged throughout the medical process. This article proposes a new device for the treatment of neonatal HIE, which has the modules of hyperbaric oxygen chamber and mild hypothermic mattress, so that neonates can receive the treatment of hyperbaric oxygen chamber and/or mild hypothermic mattress based on their conditions. Meanwhile, it can realize the real-time monitoring of various physiological information, including amplitude-integrated electroencephalogram, electrocardiogram, and near-infrared spectrum, which can monitor brain function, heart rate, rhythm, myocardial blood supply, hemoglobin concentration in brain tissue, and blood oxygen saturation. In combination with an intelligent control algorithm, the device can intelligently regulate parameters according to the physiological information of neonates and give recommendations for subsequent treatment.
关键词
缺血缺氧性脑病 /
亚低温 /
高压氧 /
智能多生理参数监测 /
新生儿
Key words
Hypoxic-ischemic encephalopathy /
Mild hypothermia /
Hyperbaric oxygen /
Intelligent multiple physiological information monitoring /
Neonate
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参考文献
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