Abstract：Kawasaki disease (KD), also known as mucocutaneous lymph node syndrome, is a systemic acute vasculitis belonging to autoimmune disease. Up to now, the specific pathogenesis of this disease remains unclear, and it may involve various factors such as immune response, inflammatory response, and vascular endothelial injury caused by the activation of the nuclear factor-kappa B (NF-κB) signaling pathway. In particular, children with KD and cardiac injury tend to have a poor prognosis, and researchers hope to explore the specific pathogenesis of cardiac injury in KD to provide new options for clinical diagnosis and treatment and reduce the incidence rate of this disorder. This article reviews the recent research on the role of the NF-κB signaling pathway in cardiac injury in children with KD, so as to provide a basis for future studies.
SUN Wen-Juan,SUN Yong-Hong. Recent research on the nuclear factor-kappa B signaling pathway in cardiac injury in children with Kawasaki disease[J]. CJCP, 2023, 25(3): 250-252.
Krajka-Ku?niak V, Baer-Dubowska W. Modulation of Nrf2 and NF-κB signaling pathways by naturally occurring compounds in relation to cancer prevention and therapy. Are combinations better than single compounds?[J]. Int J Mol Sci, 2021, 22(15):8223. PMID: 34360990. PMCID: PMC8348704. DOI: 10.3390/ijms22158223.
Korbecki J, Simińska D, G?ssowska-Dobrowolska M, et al. Chronic and cycling hypoxia: drivers of cancer chronic inflammation through HIF-1 and NF-κB activation: a review of the molecular mechanisms[J]. Int J Mol Sci, 2021, 22(19): 10701. PMID: 34639040. PMCID: PMC8509318. DOI: 10.3390/ijms221910701.
Bartekova M, Radosinska J, Jelemensky M, et al. Role of cytokines and inflammation in heart function during health and disease[J]. Heart Fail Rev, 2018, 23(5): 733-758. PMID: 29862462. DOI: 10.1007/s10741-018-9716-x.
Armaroli G, Verweyen E, Pretzer C, et al. Monocyte-derived interleukin-1β as the driver of S100A12-induced sterile inflammatory activation of human coronary artery endothelial cells: implications for the pathogenesis of Kawasaki disease[J]. Arthritis Rheumatol, 2019, 71(5): 792-804. PMID: 30447136. DOI: 10.1002/art.40784.
Bassiouni W, Ali MAM, Schulz R. Multifunctional intracellular matrix metalloproteinases: implications in disease[J]. FEBS J, 2021, 288(24): 7162-7182. PMID: 33405316. DOI: 10.1111/febs.15701.
Stock AT, Jama HA, Hansen JA, et al. TNF and IL-1 play essential but temporally distinct roles in driving cardiac inflammation in a murine model of Kawasaki disease[J]. J Immunol, 2019, 202(11): 3151-3160. PMID: 30996002. DOI: 10.4049/jimmunol.1801593.
