基于限制性立方样条模型分析青少年三酰甘油-葡萄糖指数及其衍生指数与血压异常的关系

doi:10.7499/j.issn.1008-8830.2306049

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摘要目的探讨青少年三酰甘油-葡萄糖指数（triglyceride-glucose index, 简称TyG）、三酰甘油-葡萄糖-体重指数（triglyceride-glucose-body mass index, 简称TyG-BMI）以及三酰甘油-葡萄糖-腰围指数（triglyceride-glucose-waist circumference index, 简称TyG-WC）与血压异常的关系，为青少年高血压的防控提供理论依据。方法通过分层整群抽样的方法抽取银川市1 572例12~18岁青少年进行问卷调查、体格测量和实验室检测，通过logistic回归分析模型结合限制性立方样条分析青少年TyG、TyG-BMI、TyG-WC与血压异常的关系。结果多因素logistic回归分析显示，校正混杂因素后，TyG、TyG-BMI、TyG-WC最高四分位数组发生血压异常的风险分别为最低四分位数组的1.48倍（95%CI：1.07~2.04）、3.71倍（95%CI：2.67~5.15）和4.07倍（95%CI：2.89~5.73）；且随着TyG、TyG-BMI和TyG-WC水平升高，血压异常风险逐渐增加（P<0.05）。TyG-BMI与血压异常风险之间存在非线性剂量-反应关系（P_总趋势<0.001，P_非线性=0.002）；TyG（P_总趋势<0.001，P_非线性=0.232）、TyG-WC（P_总趋势<0.001，P_非线性=0.224）均与血压异常风险之间存在线性剂量-反应关系。结论 TyG及其衍生指数水平升高可增加青少年发生血压异常的风险，且与血压异常风险之间存在线性或非线性剂量-反应关系。

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关键词 ：三酰甘油-葡萄糖指数, 三酰甘油-葡萄糖-体重指数, 三酰甘油-葡萄糖-腰围指数, 血压, 青少年

Abstract：Objective To explore the relationship of triglyceride-glucose index (TyG), triglyceride-glucose-body mass index (TyG-BMI), and triglyceride-glucose-waist circumference index (TyG-WC) with blood pressure abnormalities in adolescents, providing theoretical basis for the prevention and control of hypertension in adolescents. Methods A stratified cluster sampling method was used to select 1 572 adolescents aged 12 to 18 years in Yinchuan City for questionnaire surveys, physical measurements, and laboratory tests. Logistic regression analysis and restricted cubic spline analysis were employed to examine the relationship of TyG, TyG-BMI, and TyG-WC with blood pressure abnormalities in adolescents. Results Multivariable logistic regression analysis revealed that after adjusting for confounding factors, the groups with the highest quartile of TyG, TyG-BMI, and TyG-WC had 1.48 times (95%CI: 1.07-2.04), 3.71 times (95%CI: 2.67-5.15), and 4.07 times (95%CI: 2.89-5.73) higher risks of blood pressure abnormalities compared to the groups with the lowest quartile, respectively. Moreover, as the levels of TyG, TyG-BMI, and TyG-WC increased, the risk of blood pressure abnormalities gradually increased (P<0.05). A non-linear dose-response relationship was observed between TyG-BMI and the risk of blood pressure abnormalities (Poverall trend<0.001, Pnon-linearity=0.002). Linear dose-response relationships were found between TyG and the risk of blood pressure abnormalities (Poverall trend<0.001, Pnon-linearit =0.232), and between TyG-WC and the risk of blood pressure abnormalities (Poverall trend<0.001, Pnon-linearity=0.224). Conclusions Higher levels of TyG and its derivatives are associated with an increased risk of blood pressure abnormalities in adolescents, with linear or non-linear dose-response relationships.

Key words： Triglyceride-glucose index Triglyceride-glucose-body mass index Triglyceride-glucose-waist circumference index Blood pressure Adolescent

收稿日期: 2023-06-12

基金资助:宁夏自然科学基金项目（2023AAC03180）。

通讯作者: 丁文清，女，教授。Email：dwqdz@163.com。 E-mail: dwqdz@163.com

作者简介: 田梅，女，硕士研究生；

引用本文:

田梅,马晓燕,佟玲玲等. 基于限制性立方样条模型分析青少年三酰甘油-葡萄糖指数及其衍生指数与血压异常的关系[J]. 中国当代儿科杂志, 2024, 26(1): 54-61.

TIAN Mei,MA Xiao-Yan,TONG Ling-Ling et al. Relationship of triglyceride-glucose index and its derivatives with blood pressure abnormalities in adolescents: an analysis based on a restricted cubic spline model[J]. CJCP, 2024, 26(1): 54-61.

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