Abstract:The prevalence of short stature among prepubertal children in China is relatively high. Early identification of the cause and timely intervention can bring greater benefits to children with short stature. This paper provides an overview of early diagnosis, intervention measures, and personalized medication dosage for prepubertal short stature children, aiming to provide references for clinical doctors.
Safari O, Ejtahed HS, Namazi N, et al. Association of short stature and obesity with cardio-metabolic risk factors in Iranian children and adolescents: the CASPIAN-V study[J]. J Diabetes Metab Disord, 2021, 20(2): 1137-1144. PMID: 34900767. PMCID: PMC8630324. DOI: 10.1007/s40200-021-00831-1.
Rogol AD, Hayden GF. Etiologies and early diagnosis of short stature and growth failure in children and adolescents[J]. J Pediatr, 2014, 164(5 Suppl): S1-S14.e6. PMID: 24731744. DOI: 10.1016/j.jpeds.2014.02.027.
Growth Hormone Research Society. Consensus guidelines for the diagnosis and treatment of growth hormone (GH) deficiency in childhood and adolescence: summary statement of the GH Research Society. GH Research Society[J]. J Clin Endocrinol Metab, 2000, 85(11): 3990-3993. PMID: 11095419. DOI: 10.1210/jcem.85.11.6984.
Collett-Solberg PF, Ambler G, Backeljauw PF, et al. Diagnosis, genetics, and therapy of short stature in children: a growth hormone research society international perspective[J]. Horm Res Paediatr, 2019, 92(1): 1-14. PMID: 31514194. PMCID: PMC6979443. DOI: 10.1159/000502231.
Kim JH, Chae HW, Chin SO, et al. Diagnosis and treatment of growth hormone deficiency: a position statement from Korean Endocrine Society and Korean Society of Pediatric Endocrinology[J]. Endocrinol Metab (Seoul), 2020, 35(2): 272-287. PMID: 32615711. PMCID: PMC7386113. DOI: 10.3803/EnM.2020.35.2.272.
Grimberg A, DiVall SA, Polychronakos C, et al. Guidelines for growth hormone and insulin-like growth factor-I treatment in children and adolescents: growth hormone deficiency, idiopathic short stature, and primary insulin-like growth factor-I deficiency[J]. Horm Res Paediatr, 2016, 86(6): 361-397. PMID: 27884013. DOI: 10.1159/000452150.
Al Shaikh A, Daftardar H, Alghamdi AA, et al. Effect of growth hormone treatment on children with idiopathic short stature (ISS), idiopathic growth hormone deficiency (IGHD), small for gestational age (SGA) and Turner syndrome (TS) in a tertiary care center[J]. Acta Biomed, 2020, 91(1): 29-40. PMID: 32191651. PMCID: PMC7569569. DOI: 10.23750/abm.v91i1.9182.
Chaplin JE, Kristr?m B, Jonsson B, et al. Improvements in behaviour and self-esteem following growth hormone treatment in short prepubertal children[J]. Horm Res Paediatr, 2011, 75(4): 291-303. PMID: 21304250. DOI: 10.1159/000322937.
Maghnie M, Orso M, Polistena B, et al. Quality of life in children and adolescents with growth hormone deficiency and their caregivers: an Italian survey[J]. J Endocrinol Invest, 2023, 46(12): 2513-2523. PMID: 37209402. PMCID: PMC10632207. DOI: 10.1007/s40618-023-02106-3.
Mahfuz M, Alam MA, Das S, et al. Daily supplementation with egg, cow milk, and multiple micronutrients increases linear growth of young children with short stature[J]. J Nutr, 2020, 150(2): 394-403. PMID: . DOI: 10.1093/jn/nxz253.
Zhang Z, Li F, Hannon BA, et al. Effect of oral nutritional supplementation on growth in children with undernutrition: a systematic review and meta-analysis[J]. Nutrients, 2021, 13(9): 3036. PMID: 34578914. PMCID: PMC8468927. DOI: 10.3390/nu13093036.
Sun F, Chao L, Zhang J, et al. Exercise combined with lysine-inositol vitamin B12 promotes height growth in children with idiopathic short stature[J]. Growth Horm IGF Res, 2023, 69-70: 101535. PMID: 37245296. DOI: 10.1016/j.ghir.2023.101535.
Cohen P, Weng W, Rogol AD, et al. Dose-sparing and safety-enhancing effects of an IGF-I-based dosing regimen in short children treated with growth hormone in a 2-year randomized controlled trial: therapeutic and pharmacoeconomic considerations[J]. Clin Endocrinol (Oxf), 2014, 81(1): 71-76. PMID: 24428305. PMCID: PMC4160145. DOI: 10.1111/cen.12408.
Chen J, Zhong Y, Wei H, et al. Polyethylene glycol recombinant human growth hormone in Chinese prepubertal slow-growing short children: doses reported in a multicenter real-world study[J]. BMC Endocr Disord, 2022, 22(1): 201. PMID: 35945517. PMCID: PMC9364582. DOI: 10.1186/s12902-022-01101-8.
Jiang Z, Chen X, Dong G, et al. Short-term efficacy and safety of a lower dose of polyethylene glycol recombinant human growth hormone in children with growth hormone deficiency: a randomized, dose-comparison study[J]. Front Pharmacol, 2022, 13: 955809. PMID: 36034802. PMCID: PMC9402941. DOI: 10.3389/fphar.2022.955809.
Sun C, Lu B, Liu Y, et al. Reduced effectiveness and comparable safety in biweekly vs. weekly PEGylated recombinant human growth hormone for children with growth hormone deficiency: a phase IV non-inferiority threshold targeted trial[J]. Front Endocrinol (Lausanne), 2021, 12: 779365. PMID: 34899612. PMCID: PMC8655095. DOI: 10.3389/fendo.2021.779365.