基因多态性与新生儿败血症的遗传易感性研究进展

doi:10.7499/j.issn.1008-8830.2401065

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摘要新生儿败血症是常见的感染性疾病，病情严重，病死率高。其发病机制复杂，缺乏特异性表现，培养阳性率低，早期诊断和个体化治疗仍然是临床医生面临的挑战。对双胞胎的流行病学研究表明，遗传因素与新生儿败血症存在关联。基因多态性与其易感性、病情发展和预后密切相关。该文就新生儿败血症相关的白细胞介素、肿瘤坏死因子、Toll样受体、NOD样受体、CD14、髓系细胞触发受体1、甘露糖结合凝集素和其他免疫蛋白基因多态性进行综述，以期促进该疾病的精准医疗。

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	高静
	舒剑波
	刘洋

关键词 ：败血症, 遗传易感性, 基因多态性, 单核苷酸多态性, 新生儿

Abstract：Neonatal sepsis is a common and severe infectious disease with a high mortality rate. Its pathogenesis is complex, lacks specific manifestations, and has a low positive culture rate, making early diagnosis and personalized treatment still a challenge for clinicians. Epidemiological studies on twins have shown that genetic factors are associated with neonatal sepsis. Gene polymorphisms are closely related to susceptibility, disease development, and prognosis. This article provides a review of gene polymorphisms related to neonatal sepsis, including interleukins, tumor necrosis factor, Toll-like receptors, NOD-like receptors, CD14, triggering receptor expressed on myeloid cells-1, mannose-binding lectin, and other immune proteins, aiming to promote precision medicine for this disease.

Key words： Sepsis Genetic susceptibility Gene polymorphism Single nucleotide polymorphism Neonate

收稿日期: 2024-01-15

基金资助:天津市教委科研计划项目（2022YGYB12）；天津市科技计划项目（21JCYBJC00370）；天津市医学重点学科（专科）建设项目（TJYXZDXK-040A）。

通讯作者: 刘洋，男，主任医师。Email：etyyly@163.com。 E-mail: etyyly@163.com

作者简介: 高静，女，硕士研究生；

引用本文:

高静,舒剑波,刘洋. 基因多态性与新生儿败血症的遗传易感性研究进展[J]. 中国当代儿科杂志, 2024, 26(8): 879-886.

GAO Jing,SHU Jian-Bo,LIU Yang. Recent research on gene polymorphisms and genetic susceptibility of neonatal sepsis[J]. CJCP, 2024, 26(8): 879-886.

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