国家卫生健康行业标准《儿科输血指南》中新生儿输血的编制说明与解读

doi:10.7499/j.issn.1008-8830.2408014

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摘要为了指导儿童患者的临床输血实践，国家卫生健康委员会发布了卫生健康行业标准《儿科输血指南》（WS/T 795-2022）。考虑到新生儿时期的生理特殊性，新生儿的输血实践较其他儿童更为错综复杂，因此该指南独立设置新生儿输血一章。该文对新生儿输血条款内容的编制背景和证据作出解读，希望对该指南的新生儿输血部分的理解和贯彻实施有所助益。

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	桂嵘
	黄蓉
	杨明华
	竺晓凡
	卢俊
	徐晓军
	袁天明
	张蓉
	王旭
	刘晋萍
	王静
	邵智利
	赵明一
	郭永建
	陈佳睿
	陈琦蓉
	郭佳
	吴心音
	黑明燕
	何庆南

关键词 ：输血, 贫血, 血小板减少症, 新生儿溶血病, 新生儿

Abstract：In order to guide clinical blood transfusion practices for pediatric patients, the National Health Commission has released the health standard "Guideline for pediatric transfusion" (WS/T 795-2022). Considering the physiological particularities of the neonatal period, blood transfusion practices for neonates are more complex than those for other children, the guidelines include a separate chapter dedicated to neonatal blood transfusion. This paper interprets the background and evidence for the compilation of the neonatal blood transfusion provisions, hoping to aid in the understanding and implementation of the neonatal blood transfusion section of the guidelines.

Key words： Blood transfusion Anemia Thrombocytopenia Hemolytic disease of the newborn Neonate

收稿日期: 2024-08-02

通讯作者: 黑明燕，女，主任医师，Email：heimingyan@bch.com.cn E-mail: heimingyan@bch.com.cn

作者简介: 桂嵘，女，博士，教授，主任技师；黄蓉，女，博士，副主任技师；

引用本文:

桂嵘,黄蓉,杨明华等. 国家卫生健康行业标准《儿科输血指南》中新生儿输血的编制说明与解读[J]. 中国当代儿科杂志, 2024, 26(12): 1249-1254.

GUI Rong,HUANG Rong,YANG Ming-Hua et al. Explanation and interpretation of the compilation of neonatal blood transfusion in the national health standard "Guideline for pediatric transfusion"[J]. CJCP, 2024, 26(12): 1249-1254.

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http://www.zgddek.com/CN/10.7499/j.issn.1008-8830.2408014 或 http://www.zgddek.com/CN/Y2024/V26/I12/1249

	1 中华人民共和国国家卫生健康委员会. 关于发布《输血相容性检测标准》等3项推荐性卫生行业标准的通告: 国卫通〔2022〕1号[EB/OL]. (2022-02-23)[2022-09-01].
	2 黄蓉, 何庆南, 黑明燕, 等. 国家卫生健康行业标准《儿科输血指南》总体编制说明和解读[J]. 中国输血杂志, 2024, 37(7): 839-844. DOI: 10.13303/j.cjbt.issn.1004-549x.2024.07.021.
	Kirpalani H, Whyte RK, Andersen C, et al. The premature infants in need of transfusion (PINT) study: a randomized, controlled trial of a restrictive (low) versus liberal (high) transfusion threshold for extremely low birth weight infants[J]. J Pediatr, 2006, 149(3): 301-307. PMID: 16939737. DOI: 10.1016/j.jpeds.2006.05.011.
	Whyte RK, Kirpalani H, Asztalos EV, et al. Neurodevelopmental outcome of extremely low birth weight infants randomly assigned to restrictive or liberal hemoglobin thresholds for blood transfusion[J]. Pediatrics, 2009, 123(1): 207-213. PMID: 19117884. DOI: 10.1542/peds.2008-0338.
	Kirpalani H, Bell EF, Hintz SR, et al. Higher or lower hemoglobin transfusion thresholds for preterm infants[J]. N Engl J Med, 2020, 383(27): 2639-2651. PMID: 33382931. PMCID: PMC8487591. DOI: 10.1056/NEJMoa2020248.
	Franz AR, Engel C, Bassler D, et al. Effects of liberal vs restrictive transfusion thresholds on survival and neurocognitive outcomes in extremely low-birth-weight infants: the ETTNO randomized clinical trial[J]. JAMA, 2020, 324(6): 560-570. PMID: 32780138. PMCID: PMC7420159. DOI: 10.1001/jama.2020.10690.
	Ozcan B, Aydemir O, Isik DU, et al. Severe anemia is associated with intestinal injury in preterm neonates[J]. Am J Perinatol, 2020, 37(6): 603-606. PMID: 30947347. DOI: 10.1055/s-0039-1683982.
	Arthur CM, Nalbant D, Feldman HA, et al. Anemia induces gut inflammation and injury in an animal model of preterm infants[J]. Transfusion, 2019, 59(4): 1233-1245. PMID: 30897226. PMCID: PMC6525338. DOI: 10.1111/trf.15254.
	Whitehead HV, Vesoulis ZA, Maheshwari A, et al. Anemia of prematurity and cerebral near-infrared spectroscopy: should transfusion thresholds in preterm infants be revised?[J]. J Perinatol, 2018, 38(8): 1022-1029. PMID: 29740185. PMCID: PMC6136959. DOI: 10.1038/s41372-018-0120-0.
	Flannery DD, Foglia EE. The contributions of red blood cell transfusion and severe anemia in necrotizing enterocolitis: causes or confounders?[J]. J Perinatol, 2017, 37(6): 626-628. PMID: 28333160. DOI: 10.1038/jp.2017.32.
	Patel RM, Knezevic A, Shenvi N, et al. Association of red blood cell transfusion, anemia, and necrotizing enterocolitis in very low-birth-weight infants[J]. JAMA, 2016, 315(9): 889-897. PMID: 26934258. PMCID: PMC4805423. DOI: 10.1001/jama.2016.1204.
	Roberts I, Stanworth S, Murray NA. Thrombocytopenia in the neonate[J]. Blood Rev, 2008, 22(4): 173-186. PMID: 18433954. DOI: 10.1016/j.blre.2008.03.004.
	Andrew M, Vegh P, Caco C, et al. A randomized, controlled trial of platelet transfusions in thrombocytopenic premature infants[J]. J Pediatr, 1993, 123(2): 285-291. PMID: 8345429. DOI: 10.1016/s0022-3476(05)81705-6.
	Curley A, Stanworth SJ, Willoughby K, et al. Randomized trial of platelet-transfusion thresholds in neonates[J]. N Engl J Med, 2019, 380(3): 242-251. PMID: 30387697. DOI: 10.1056/NEJMoa1807320.
	Sola-Visner MC. Platelet transfusions in neonates: less is more[J]. N Engl J Med, 2019, 380(3): 287-288. PMID: 30650325. DOI: 10.1056/NEJMe1813419.
	中华医学会儿科学分会新生儿学组, 《中华儿科杂志》编辑委员会. 新生儿高胆红素血症诊断和治疗专家共识[J]. 中华儿科杂志, 2014, 52(10): 745-748. PMID: 25537539. DOI: 10.3760/cma.j.issn.0578-1310.2014.10.006.
	American Academy of Pediatrics Subcommittee on Hyperbilirubinemia. Management of hyperbilirubinemia in the newborn infant 35 or more weeks of gestation[J]. Pediatrics, 2004, 114(1): 297-316. PMID: 15231951. DOI: 10.1542/peds.114.1.297.
	Watchko JF. Bilirubin-induced neurotoxicity in the preterm neonate[J]. Clin Perinatol, 2016, 43(2): 297-311. PMID: 27235209. DOI: 10.1016/j.clp.2016.01.007.
	Kemper AR, Newman TB, Slaughter JL, et al. Clinical practice guideline revision: management of hyperbilirubinemia in the newborn infant 35 or more weeks of gestation[J]. Pediatrics, 2022, 150(3): e2022058859. PMID: 35927462. DOI: 10.1542/peds.2022-058859.
	Sproul A, Smith L. Bilirubin equilibration during exchange transfusion in hemolytic disease of the newborn[J]. J Pediatr, 1964, 65: 12-26. PMID: 14178816. DOI: 10.1016/s0022-3476(64)80547-3.
	Forfar JO, Keay AJ, Elliott WD, et al. Exchange transfusion in neonatal hyperbilirubin?mia[J]. Lancet, 1958, 2(7057): 1131-1137. PMID: 13612139. DOI: 10.1016/s0140-6736(58)92402-4.
	Banerjee J, Aladangady N. Biomarkers to decide red blood cell transfusion in newborn infants[J]. Transfusion, 2014, 54(10): 2574-2582. PMID: 24797124. DOI: 10.1111/trf.12670.
	Kalteren WS, Verhagen EA, Mintzer JP, et al. Anemia and red blood cell transfusions, cerebral oxygenation, brain injury and development, and neurodevelopmental outcome in preterm infants: a systematic review[J]. Front Pediatr, 2021, 9: 644462. PMID: 33718309. PMCID: PMC7952449. DOI: 10.3389/fped.2021.644462.