胰岛素抵抗与子宫体积在特发性中枢性性早熟女童中的关联研究

张红如; 肖雅; 姜书琴; 孙俊; 史文慧; 李锦波; 杨莹; 王伟

doi:10.7499/j.issn.1008-8830.2411003

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中国当代儿科杂志 ›› 2025, Vol. 27 ›› Issue (4) : 404-409. DOI: 10.7499/j.issn.1008-8830.2411003

论著·临床研究

胰岛素抵抗与子宫体积在特发性中枢性性早熟女童中的关联研究

张红如, 肖雅, 姜书琴, 孙俊, 史文慧, 李锦波, 杨莹, 王伟

作者信息 +

Association between insulin resistance and uterine volume in girls with idiopathic central precocious puberty

ZHANG Hong-Ru, XIAO Ya, JIANG Shu-Qin, SUN Jun, SHI Wen-Hui, LI Jin-Bo, YANG Ying, WANG Wei

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文章历史 +

摘要

目的探究特发性中枢性性早熟（idiopathic central precocious puberty, ICPP）女童胰岛素抵抗程度与子宫体积之间的关联。方法回顾性选取2022年1月—2024年9月于郑州大学第三附属医院儿科生长发育门诊就诊并诊断为ICPP的61例女童作为ICPP组，以及61例正常生长发育的女童作为对照组。比较两组稳态模型胰岛素抵抗指数（homeostasis model assessment of insulin resistance, HOMA-IR）、子宫体积以及其他指标的差异，并分析胰岛素抵抗与女童子宫体积之间的关系。结果 ICPP组子宫体积、HOMA-IR大于对照组（P<0.05）。相关性分析表明，ICPP组HOMA-IR水平与子宫体积呈正相关（r_s=0.643，P<0.001）。多元线性回归分析结果显示，随着HOMA-IR升高，女童子宫体积呈上升趋势（P<0.05）。结论 ICPP女童的胰岛素抵抗与子宫体积之间存在关联，且随着HOMA-IR升高，女童子宫体积随之增大。

Abstract

Objective To investigate the association between insulin resistance and uterine volume in girls with idiopathic central precocious puberty (ICPP). Methods A retrospective study was conducted involving 61 girls diagnosed with ICPP who visited the pediatric growth and development clinic of the Third Affiliated Hospital of Zhengzhou University between January 2022 and September 2024, designated as the ICPP group, and 61 normally developing girls as the control group. The differences in insulin resistance index (homeostasis model assessment of insulin resistance, HOMA-IR), uterine volume, and other indicators between the two groups were compared, and the relationship between insulin resistance and uterine volume in these girls was analyzed. Results The uterine volume and HOMA-IR level in the ICPP group were significantly higher than those in the control group (P<0.05). Correlation analysis revealed that there was a positive correlation between HOMA-IR level and uterine volume in the ICPP group (r_s=0.643, P<0.001). Multiple linear regression analysis indicated that as HOMA-IR increased,uterine volume in the girls tended to increase (P<0.05). Conclusions There is an association between insulin resistance and uterine volume in girls with ICPP, and as HOMA-IR increases, uterine volume in the girls also increases.

导出引用

张红如, 肖雅, 姜书琴, 孙俊, 史文慧, 李锦波, 杨莹, 王伟. 胰岛素抵抗与子宫体积在特发性中枢性性早熟女童中的关联研究[J]. 中国当代儿科杂志. 2025, 27(4): 404-409 https://doi.org/10.7499/j.issn.1008-8830.2411003

ZHANG Hong-Ru, XIAO Ya, JIANG Shu-Qin, SUN Jun, SHI Wen-Hui, LI Jin-Bo, YANG Ying, WANG Wei. Association between insulin resistance and uterine volume in girls with idiopathic central precocious puberty[J]. Chinese Journal of Contemporary Pediatrics. 2025, 27(4): 404-409 https://doi.org/10.7499/j.issn.1008-8830.2411003

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