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| 新型气体信号分子硫化氢在心血管疾病中的意义 |
| 王新宝，金红芳，杜军保 |
| 北京大学第一医院儿科 北京100034 |
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| Role of gas signaling molecule hydrogen sulfide in cardiovascular diseases |
| WANG Xin-Bao, JIN Hong-Fan, DU Jun-Bao |
| Department of Pediatrics, Peking University First Hospital, Beijing 100034, China |
| ［1］耿彬，闫辉, 钟光珍, 张春雨, 陈晓波, 蒋宏峰，等.硫化氢-心血管功能调节的新型气体信号分子［J］.北京大学学报（医学版）, 2004, 36(1):106.
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| ［2］Stipanuk MH, Beck PK. Characterization of enzymic capacity for cysteine desulphhydration in liver and kidney of the rat［J］. Biochem J, 1982, 206(2):267-277.
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| ［3］Wang R. Two′s company, three′s crowd: can H2S be the third endogenous gaseous transmitter?［J］. FASEB J, 2002,16（13）:1792-1798.
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| ［4］Abe K, Kimura H. The possible role of hydrogen sulfide as an endogenous neuromodulator［J］. J Neurosci, 1996, 16(3):1066-1071.
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| ［5］Zhao W, Zhang J, Lu Y, Wang R. The vasorelaxant effect of H2S as a novel endogenous gaseous KATP channel opener［J］. EMBO J, 2001, 20（21）:6008-6016.
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| ［6］Tang G, Wu L, Liang W, Wang R. Direct stimulation of KATP channels by exogenous and endogenous hydrogen sulfide in vascular smooth muscle cells［J］. Mol Pharmacol, 2005, 68（6）:1757-1764.
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| ［7］Olson KR, Forgan LG, Dombkowski RA, Forster ME.Oxygen dependency of hydrogen sulfide-mediated vasoconstriction in cyclostome aortas［J］. J Exp Biol, 2008, 211(14):2205-2213.
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| ［8］Lim JJ, Liu Y, Khin ESW, Bian JS.Vasoconstrictive effect of hydrogen sulfide involves down regulation of cAMP in vascular smooth muscle cells［J］. Am J Physiol Cell Physiol, 2008, 295(5):C1261-1270.
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| ［9］Geng B, Yang J, Qi Y, Zhao J, Pang Y, Du J, et al. H2S generated by heart in rat and its effects on cardiac function［J］. Biochem Biophys Res Commun, 2004, 313(2):362-368.
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| ［10］杜军保，陈晓波，耿彬, 蒋宏峰, 唐朝枢. 硫化氢作为心血管信号分子的研究［J］.北京大学学报（医学版），2002, 34(2):187.
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| ［11］Jin HF, Cong BL, Zhao B, Zhang CY, Liu XM, Zhou WJ, et al. Effects of hydrogen sulfide on hypoxic pulmonary vascular structural remodeling［J］. Life Sci, 2006, 78(12):1299-1309.
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| ［12］Du J, Hui Y, Cheung Y, Bin G, Jiang H, Chen X, et al. The possible role of hydrogen sulfide as a smooth muscle cell proliferation inhibitor in rat cultured cells［J］. Heart Vessels, 2004, 19(2):75-80.
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| ［13］Yang G, Sun X, Wang R. Hydrogen sulfide-induced apoptosis of human aorta smooth muscle cells via the activation of mitogen-activated protein kinases and caspase-3［J］. FASEB J, 2004, 18(14):1782-1784.
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| ［14］张春雨，杜军保，卜定方, 闫辉，斯琴，唐朝枢.低氧性肺动脉高压大鼠肺组织硫化氢的变化［J］. 基础医学与临床, 2004, 24(2):145-148.
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| ［15］陈晓波,杜军保，张春雨,唐朝枢.新型气体信号分子硫化氢对低氧性肺动脉高压和肺血管结构重建的调节作用［J］.中华儿科杂志, 2004, 42(4):303-304.
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| ［16］李晓惠, 杜军保, 唐朝枢.内源性硫化氢对大鼠高肺血流性肺动脉高压的调节作用［J］.临床儿科杂志, 2006, 24(8):674-676.
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| ［17］石琳,杜军保,卜定方, 齐建光, 魏冰, 唐朝枢,等.高肺血流量对肺血管结构及胱硫醚-γ-裂解酶基因表达的影响［J］. 北京大学学报(医学版), 2003, 35(6):566-570.
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| ［18］李晓惠，杜军保，唐朝枢. 硫化氢供体对高肺血流性肺动脉高压大鼠肺动脉胶原含量及代谢的影响［J］. 中国药理学通报, 2007, 23(6):760-764.
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| ［19］Yan H, Du J, Tang C. The possible role of hydrogen sulfide on the pathogenesis of spontaneous hypertension in rats［J］.Biochem Biophys Res Commun, 2004, 313(1):22-27.
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| ［20］闫辉,杜军保,唐朝枢.自发性高血压大鼠硫化氢/胱硫醚-γ-裂解酶体系的实验观察［J］.中华医学杂志, 2004, 84(13):1114-1117.
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| ［21］金红芳，田悦，闫辉, 唐朝枢，杜军保.硫化氢对正常及自发性高血压大鼠主动脉平滑肌细胞PCNA和p-ERK蛋白表达的影响［J］. 中国药理学通报, 2008, 24(2):160-165.
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| ［22］孙宁玲,喜杨,杨松娜,马旃,唐朝枢.新型气体信号分子硫化氢与同型半胱氨酸在高血压患者中的变化探讨［J］.中华心血管病杂志，2007, 35(12):1145-1148.
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| ［23］喜杨, 孙宁玲, 马旃.气体信号分子硫化氢与一氧化氮在高血压患者中的变化探讨［J］.中国循环杂志, 2007, 22(4):246-249.
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| ［24］江海龙 ，吴宏超，李志梁, 耿彬，唐朝枢. 冠心病患者血浆中新型气体信号分子硫化氢的变化［J］. 第一军医大学学报, 2005, 25(8):951-954.
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| ［25］Geng B, Chang L, Pan CS, Qi YF, Zhao J, Pang YZ, et a1.Endogenous hydrogen sulfide regulation of myocardial injury induced by isoproterenol［J］. Biochem Biophys Res Commun, 2004, 318(3):756-763.
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| ［26］王燕飞，唐朝枢，杜军保. 硫化氢供体对Apo E基因敲除小鼠动脉粥样硬化的调节作用［J］.中国药理学通报，2008, 24(10):1293-1296.
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| ［27］Johansen D, Ytrehus K, Baxter GF. Exogenous hydrogen sulfide (H2S) protects against regional myocardial ischemia-reperfusion injury evidence for a role of K-ATP channels［J］. Basic Res Cardiol, 2006, 101(1):53-60.
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| ［28］Bliksoen M, Kaljusto ML, Vaage J, Stenslkken KO. Effects of hydrogen sulphide on ischaemia-reperfusion injury and ischaemic preconditioning in the isolated, perfused rat heart ［J］. Eur J Cardiothorac Surg, 2008, 34(2):344-349.
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| ［29］Whiteman M, Armstrong JS, Chu SH, Jia-Ling S, Boon-Seng W, Cheung NS, et al. The novel neuromodulator hydrogen sulfide: an endogenous peroxynitrite ′scavenger′ ?［J］. J Neurochem, 2004, 90(3):765-768.
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| ［30］常芳，李凌，常庆. 硫化氢对大鼠心肌缺血再灌注损伤的保护作用［J］. 中原医刊, 2005, 32(9):2-3.
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| ［31］Fiorucci S, Antonelli E, Distrutti E, Rizzo G, Mencareli A, Orlandi S, et al. Inhibition of hydrogen sulfide generation contributes to gastric injury caused by anti-inflammatory nonsteroidal drugs［J］. Gastroenterology, 2005, 129(4):1210-1224.
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| ［32］Sodha NR, Clements RT, Feng J, Liu Y, Bianchi C, Horvath EM, et al. The effects of therapeutic sulfide on myocardial apoptosis in response to ischemia-reperfusion injury［J］. Eur J Cardiothorac Surg, 2008, 33(5):906-913.
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| ［33］Pan TT, Feng ZN, Lee SW, Moore PK, Bian JS.Endogenous hydrogen sulfide contributes to the cardioprotection by metabolic inhibition preconditioning in the rat ventricular myocytes［J］. J Mol Cell Cardiol, 2006, 40(1):119-130.
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| ［34］Hu YS, Chen X, Pan TT, Neo KL, Lee SW, Khin ESW, et al. Cardioprotection induced by hydrogen sulfide preconditioning involves activation of ERK and PI3K/Akt pathways［J］. Eur J Physiol, 2008, 455(4):607-616.
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| ［35］Ji Y, Pang QF, Xu G, Wang L, Wang JK, Zeng YM. Exogenous hydrogen sulfide postconditioning protects isolated rat hearts against ischemiareperfusion injury［J］. Eur J Pharmacol, 2008, 587(1-3):1-7.
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| ［36］Yan H, Du JB, Tang CS, Geng B, Jiang H. Changes in arterial hydrogen sulfide (H(2)S) content during septic shock and endotoxin shock in rats［J］. J Infect, 2003, 47(2):155-160.
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| ［37］Mok YY, Atan MS, Ping CY, Wang ZJ, Bhatia M, Moochhala S, et al. Role of hydrogen sulphide in haemorrhagic shock in the rat: protective effect of inhibitors of hydrogen sulphide biosynthesis［J］. Br J Pharmacol, 2004, 143（7）：881-889.
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| ［38］Mok YY, Moore PK. Hydrogen sulphide is pro-inflammatory in haemorrhagic shock［J］. Inflamm Res, 2008, 57(11):512-518.
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| ［39］Li L, Bhatia M, Zhu YZ, Zhu YC, Ramnath RD, Wang ZJ, et al. Hydrogen sulfide is a novel mediator of lipopolysaccharide-induced inflammation in the mouse［J］. Faseb J, 2005, 19(9):1196-1198.
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| ［40］田悦.低氧性肺动脉高压发生机制中气体信号分子的病理生理学意义［J］.中国当代儿科杂志，2008，10（1）：98-101.
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