|
|
|
| 系膜重构在肾小球疾病中的作用研究进展 |
| 茹颖，宋红梅 |
| 中国医学科学院 北京协和医学院北京协和医院儿科，北京100730 |
|
| Progress in the research on the role of mesangial remodeling in glomerualr diseases |
| RU Ying, SONG Hong-Mei. |
| Department of Pediatrics, Peking Union Medical College, Beijing 100730, China |
| ［1］Kagami S, Kondo S, Urushihara M, Loster K, Reutter W, Saijo T, et al. Overexpression of α1β1 integrin directly affects rat mesangial cell behavior［J］. Kidney Int,2000,58(3):1088-1097.
|
| ［2］Prols F, Hartner A, Schocklmann HO, Sterzel RB. Mesangial cells and their adhesive properties［J］. Exp Nephrol, 1999, 7(2):137-146.
|
| ［3］Zhang LS, Nakazawa K, Shigematsu H. Participation of endothelial cells and transformed mesangial cells in remodeling of glomerular capillary loops in Thy-1 nephritis［J］. Pathol Int, 2001, 51(4):227-239.
|
| ［4］Zhang LS, Aoyagi D, Nakazawa K, Otani M. Postinflammatory glomerular remodeling is influenced by transformed mesangial cells［J］. Pathol Int, 2005, 55(4):189-201.
|
| ［5］Eddy AA. Molecular basis of renal fibrosis［J］. Pediatr Nephrol, 2000, 15(3-4):290-301.
|
| ［6］Hawai K, Mukoyama M, Mori K, Kasahara M, Koshikawa M, Yokoi H, et al. Expression of CCN1 (CYR61) in developing, normal, and diseased human kidney［J］. Am J Physiol Renal Physiol, 2007, 293(4):F1363-1372.
|
| ［7］Sawai K, Mori K, Mukoyama M, Sugawara A, Suganami T, Koshikawa M, et al. Angiogenic protein cyr61 is expressed by podocytes in anti-Thy-1 glomerulonephritis［J］. J Am Soc Nephrol, 2003, 14(5):1154-1163.
|
| ［8］Kagami S, Urushihara M, Kitamura A, Kondo S, Hisayama T, Kitamura M, et al. PDGF-BB enhances alpha1beta1 integrin-mediated activation of the ERK/AP-1 pathway involved in collagen matrix remodeling by rat mesangial cells［J］. J Cell Physiol, 2004, 198(3):470-478.
|
| ［9］Dubey RK, Gillespie DG, Mi Z, Jackson EK. Adenosine inhibits PDGF-induced growth of human glomerular mesangial cells via A(2B) receptors［J］. Hypertension, 2005, 46(3):628-634.
|
| ［10］Socha MJ, Manhiani M, Said N, Imig JD, Motamed K. Secreted protein acidic and rich in cysteine deficiency ameliorates renal inflammation and fibrosis in angiotensin hypertension［J］. Am J Pathol, 2007, 171(4):1104-1112.
|
| ［11］Furlong F, Crean J, Thornton L, O′Leary R, Murphy M, Martin F, et al. Dysregulated intracellular signaling impairs CTGF-stimulated responses in human mesangial cells exposed to high extracellular glucose［J］. Am J Physiol Renal Physiol, 2007, 292(6):F1691-F1700.
|
| ［12］Tahara A, Tsukada J, Tomura Y, Suzuki T, Yatsu T, Shibasaki M. Effect of vasopressin on type IV collagen production in human mesangial cells［J］. Regul Pept, 2008, 147(13):60-66.
|
| ［13］Mizui M, Isaka Y, Takabatake Y, Sato Y, Kawachi H, Shimizu F, et al. Transcription factor Ets-1 is essential for mesangial matrix remodeling［J］. Kidney Int, 2006, 70(2):298-305.
|
| ［14］Kitamura A, Kagami S, Urushihara M, Kondo S, Yoshizumi M, Tamaki T, et al. Endothelin-1 is a potent stimulator of α1β1 integrin-mediated collagen matrix remodeling by rat mesangial cells［J］. Biochem Biophys Res Commun, 2002, 299(4):555-561.
|
| ［15］Mishra R, Leahy P, Simonson MS. Gene expression profile of endothelin-1-induced growth in glomerular mesangial cells［J］. Am J Physiol Cell Physiol, 2003, 285(5):C1109-1115.
|
| ［16］Kagami S, Kondo S. Beta1-integrins and glomerular injury［J］. J Med Inv, 2004, 51(3):112-113.
|
| ［17］Cook H, Khan S, Allen A, Bhangal G, Smith J, Lobb R, et al. Treatment with an antibody to VLA-1 integrin reduces glomerular and tubulointerstitial scarring in a rat model of crescentic glomerulonephritis［J］. Am J Pathol, 2002, 161(4):1265-1272.
|
| ［18］Cosgrove D, Rodgers K, Meehan D, Miller C, Bovard K, Gilroy A,et al. Integrin α1β1 and transforming growth factor-β1 play distinct roles in alport glomerular pathogenesis and serve as dual targets for metabolic therapy［J］. Am J Pathol, 2000, 157(5):1649-1659.
|
| ［19］Kagami S, Shimizu M, Kondo S, Kitamura A, Urushihara M, Takamatsu M, et al. Up-regulation of integrin-linked kinase activity in rat mesangioproliferative glomerulonephritis［J］. Life Sci, 2006, 78(16):1794-1800.
|
|
|
|
