Abstract：OBJECTIVE: To study serum levels of melatonin in children with epilepsy or febrile seizures in order to provide a basis for the treatment of epilepsy or febrile seizures with melatonin. METHODS: Serum melatonin levels were measured using ELISA in 15 children with simple febrile seizure (SFS), in 15 children with complex febrile seizure (CFS), in 15 children with epilepsy, and in 15 children with upper respiratory infections (control group). RESULTS: Serum melatonin levels in children with epilepsy (8.66±1.38 ng/L) or CFS (14.91±2.61 ng/L) were significant lower than those in the control group (23.93±2.01 ng/L) (P<0.01). The SFS group showed lower serum melatonin levels (20.72±2.54 ng/L) compared with the control group, but there were no statistical differences between the two groups. Serum melatonin levels in the epilepsy group were significantly lower than those in the CFS (P<0.05) and the SFS groups (P<0.01). CONCLUSIONS: Serum melatonin levels decreased in children with epilepsy or CFS. Supplement of exogenous melatonin might be a promising treatment for epilepsy and febrile seizures in children.［Chin J Contemp Pediatr, 2009, 11 (4):288-290］
［10］Borowicz KK, Kaminski R, Gasior M. Influence of melatonin upon the protective action of conventional anti-epileptic drugs against maximal electroshock in mice［J］. Eur Neuropsychopharmacol, 1999, 9(3):185-190.
［15］Coppola G, Iervolino G, Mastrosimone M, La Torre G, Ruiu F, Pascotto A. Melatonin in wake-sleep disorders in children, adolescents and young adults with mental retardation with or without epilepsy: a double-blind, cross-over, placebo-controlled trial［J］．Brain Dev, 2004, 26(6):373-376.
［16］Peled N, Shorer Z, Peled E, Pillar G. Melatonin effect on seizures in children with severe neurologic deficit disorders［J］.Epilepsia, 2001, 42(9):1208-1210.
［17］Gupta M, Aneja S, Kohli K. Add-on melatonin improves quality of life in epileptic children on valproate monotherapy:a randomized,double-blind,placebo-controlled trial［J］.Epilepsy Behav, 2004, 5(3):316-321.
