Abstract Objective To explore the effects of body mass index (BMI) and the levels of serum inflammatory cytokines on asthma control in children with asthma. Methods One hundred and sixteen children with asthma were divided into three groups: normal (n=59), thin (n=31), and obesity (n=26) based on their BMI. The levels of interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) were determined using ELISA, and the level of high-sensitivity C-reactive protein (hs-CRP) was measured by immunoturbidimetric assays. Asthma control status in each group was evaluated by the Childhood Asthma Control Test (C-ACT) after 4 weeks of treatment. Results The serum levels of IL-6, hs-CRP, and TNF-α were highest in the obesity group, followed by the thin group and the normal group (PPPP>0.05). The levels of IL-6, hs-CRP, and TNF-α were negatively correlated with the C-ACT score (PP>0.05). Conclusions When BMI is too high or too low, the levels of serum inflammatory cytokines are all increased, which is harmful to asthma control. Maintaining a healthy weight in children with asthma may reduce the levels of serum inflammatory cytokines and improve the asthma control rate.
About author:: 10.7499/j.issn.1008-8830.2015.07.011
Cite this article:
CHEN Xiao-Jian,ZHANG Yue-Hua,WANG Dan-Hong et al. Effects of body mass index and serum inflammatory cytokines on asthma control in children with asthma[J]. CJCP, 2015, 17(7): 698-701.
CHEN Xiao-Jian,ZHANG Yue-Hua,WANG Dan-Hong et al. Effects of body mass index and serum inflammatory cytokines on asthma control in children with asthma[J]. CJCP, 2015, 17(7): 698-701.
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