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Clinicopathological features of children with lupus nephritis with positive antineutrophil cytoplasmic antibody
WEN Si-Jia, CHEN Li-Zhi, CHENG Cheng, LIN Zhi-Lang, MO Ying, JIANG Xiao-Yun
Chinese Journal of Contemporary Pediatrics ›› 2021, Vol. 23 ›› Issue (1) : 55-60.
PDF(1464 KB)
PDF(1464 KB)
Clinicopathological features of children with lupus nephritis with positive antineutrophil cytoplasmic antibody
Objective To study the clinicopathological features of children with lupus nephritis (LN) with positive anti-neutrophil cytoplasmic antibody (ANCA). Methods A retrospective analysis was performed for the children who were diagnosed with LN in the First Affiliated Hospital of Sun Yat-sen University from January 2003 to December 2019. According to the results of serum ANCA, they were divided into two groups: ANCA-positive group (n=59) and ANCAnegative group (n=454). The two groups were compared in terms of clinical manifestations, histopathological features, remission rate, and prognosis. Results Compared with the ANCA-negative group, the ANCA-positive group had a significant reduction in leukocytes and a significant increase in erythrocyte sedimentation rate (P < 0.05). There were no significant differences between the two groups in serum creatinine, urine protein, and urine red blood cell count (P > 0.05). A total of 308 children underwent kidney biopsy. The results on light microscopy showed that compared with the ANCAnegative group, the ANCA-positive group had a significantly higher proportion of children with cellular fibrous crescents (P < 0.05) and a significantly lower proportion of children with immune complex deposition (P < 0.05). There were no significant differences between the two groups in the remission rate and survival rate (P > 0.05). Conclusions Children with ANCA-positive LN tend to have more severe renal pathological injury, which is not exactly parallel with clinical manifestations, suggesting that timely renal biopsy is of great importance.
Systemic lupus erythematosus / Lupus nephritis / Anti-neutrophil cytoplasmic antibody / Clinicopathological feature / Child
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