OBJECTIVE: To study the relationship between the incidence and mortalit y of the multiple organ dysfunction syndrome(MODS) following asphyxia and the seve rity of asphyxia, pregnant age and birth weight in neonates. METHODS: A prospective study was done in 100 neonates with asphyxia. RESULTS: The incidence of MODS in the severe asphyxia neonates(severe group)(71.4%) was much higher than that in the mild asphyxia neonates(mild group)(30.8%)(P < 0.01); th e incidence of brai n, lung , cardiovascular system, kidney and gastroenteric damage in the severe group was 91.4 %,77.1 %, 54.3 %, 34.3 % and 22.9 % ,respectively. It differed signi ficantly fro m that in the mild group(38.5%, 33.8%, 20.0%,12.3% and 7.7%,respectively) (P <0.01 or 0.05).Ho wever, there was no significant difference in the incidence of liver damage bet ween the two groups.The mortality in the severe group(22.9%) wa s much highe r than that in the mild group(6.2%)(P < 0.05).There was a close correlat ion bet ween the incidence and mortality of MODS and the pregnant age and birth weight; the incidence and mortality of MODS in premature neonates and low birth weight neonates were higher than those in full?term neonates and normal birth weight ne onates(P < 0.05). CONCLUSIONS: The key issue of reducing the incidence of MOD S following asphyxia is to improve perinatal care and reduce the incidence of pr eterm birt h and low birth weight neonates. It is also necessary to take measur es to prevent asphyxia in neonates."/>
Relationship between Neonatal Asphyxia and the Multiple Organ Dysfunction yndrome
Abstract OBJECTIVE: To study the relationship between the incidence and mortalit y of the multiple organ dysfunction syndrome(MODS) following asphyxia and the seve rity of asphyxia, pregnant age and birth weight in neonates. METHODS: A prospective study was done in 100 neonates with asphyxia. RESULTS: The incidence of MODS in the severe asphyxia neonates(severe group)(71.4%) was much higher than that in the mild asphyxia neonates(mild group)(30.8%)(P < 0.01); th e incidence of brai n, lung , cardiovascular system, kidney and gastroenteric damage in the severe group was 91.4 %,77.1 %, 54.3 %, 34.3 % and 22.9 % ,respectively. It differed signi ficantly fro m that in the mild group(38.5%, 33.8%, 20.0%,12.3% and 7.7%,respectively) (P <0.01 or 0.05).Ho wever, there was no significant difference in the incidence of liver damage bet ween the two groups.The mortality in the severe group(22.9%) wa s much highe r than that in the mild group(6.2%)(P < 0.05).There was a close correlat ion bet ween the incidence and mortality of MODS and the pregnant age and birth weight; the incidence and mortality of MODS in premature neonates and low birth weight neonates were higher than those in full?term neonates and normal birth weight ne onates(P < 0.05). CONCLUSIONS: The key issue of reducing the incidence of MOD S following asphyxia is to improve perinatal care and reduce the incidence of pr eterm birt h and low birth weight neonates. It is also necessary to take measur es to prevent asphyxia in neonates.
WU Li-Na,MAI Zhi-Guang,LUO Chang-Shou. Relationship between Neonatal Asphyxia and the Multiple Organ Dysfunction yndrome[J]. 中国当代儿科杂志, 2002, 4(2): 111-113.
WU Li-Na,MAI Zhi-Guang,LUO Chang-Shou. Relationship between Neonatal Asphyxia and the Multiple Organ Dysfunction yndrome[J]. CJCP, 2002, 4(2): 111-113.
