Abstract OBJECTIVE: To study therapeutic effect and safety of early administration of oral ibuprofen in very low birth weight infants (VLBWIs) with patent ductus arteriosus (PDA). METHODS: A total of 64 symptomatic VLBWIs (within 24 hours after birth) with PDA confirmed by bedside Color Doppler ultrasound were randomly divided into two groups: treatment and control (n = 32 each). The treatment group was orally administered ibuprofen within 24 hours after birth at 10 mg/kg, followed 24 hours later by a second dose of 5 mg/kg and 48 hours later by a third dose of 5 mg/kg. The control group was treated with placebo (normal saline) at 1 mL/kg, followed 24 hours later by a second dose of 0.5 mL/kg and 48 hours later by a third dose of 0.5 mL/kg. The therapeutic efficacies and adverse effects in both groups were observed. RESULTS: The treatment group showed a significantly higher closure rate of ductus arterious than the control group after one course of treatment (84% vs 41%; P0.05). No obvious adverse effects were observed in both groups. CONCLUSIONS: Early administration of oral ibuprofen for treatment of PDA in VLBWIs can decrease the incidence rates of some early complications and shorten hospitalization time, but causes no significant adverse effects.
LIN Xin-Zhu,CHEN Han-Qiang,ZHENG Zhi et al. Therapeutic effect of early administration of oral ibuprofen in very low birth weight infants with patent ductus arteriosus[J]. 中国当代儿科杂志, 2012, 14(07): 502-505.
LIN Xin-Zhu,CHEN Han-Qiang,ZHENG Zhi et al. Therapeutic effect of early administration of oral ibuprofen in very low birth weight infants with patent ductus arteriosus[J]. CJCP, 2012, 14(07): 502-505.
［2］Malviya M, Ohlsson A, Shah S. Surgical versus medical treatment with cyclooxygenase inhibitors for symptomatic patent ductus arteriosus in preterm infants［J/OL］. Cochrane Database Syst Rev, 2008, (1): CD003951.
［7］Clyman RI. Recommendations for the postnatal use of indomethacin:an analysis of four separate treatment strategies［J］. J Pediatr, 1996, 128(5 Pt 1): 601-607.
［8］Fakhraee SH, Badiee Z, Mojtahedzadeh S, Kazemian M, Kelishadi R, Beheshti S. Comparison of oral ibuprofen and indomethacin therapy for patent ductus arteriosus in preterm infants［J］. 中国当代儿科杂志，2007，9（5）：399-403
［9］Satar M, Yapicioglu H, Narli N, Ozbarlas N, Ku-ükosmanoglu O, Tutak E. Is oral indomethacin effective in treatment of preterm infants with patent ductus arteriosus? ［J］. Turk J Pediatr, 2004, 46(2): 137-141.
［10］Domanico RS, Waldman JD, Lester LA. Prophylactic indomethacin reduces the incidence of pulmonary hemorrhage and patent ductus arteriosus in surfactant treated infants 1250 grams［J］. Pediatr Res, 1994, 35: 331A.
