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中国当代儿科杂志  2012, Vol. 14 Issue (12): 938-941    DOI:
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Risk factors for coronary artery lesions in children with Kawasaki disease
LI Yan, WANG Xian-Min, LIU Yi-Ling, SHI Kun, YANG Yan-Feng, GUO Yong-Hong
Department of Pediatric Cardiology, Chengdu Women and Children's Central Hospital, Chengdu 610017, China. 1983777939@qq.com
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Abstract  OBJECTIVE: To study risk factors for the development of coronary artery lesions (CAL) in children with Kawasaki disease (KD). METHODS: The clinical data of 527 children with KD between January 2006 and January 2009 were retrospectively reviewed. A total of 15 potential factors associated with occurrence of CAL were evaluated by univariate analysis and multivariate logistic regression analysis. RESULTS: The univariate analysis showed that age, gender, KD type, starting time of intravenous immunoglobulin (IVIG) treatment, response to IVIG treatment, additional treatment with corticosteroids, duration of fever and serum C-reactive protein level were significantly different between patients with and without CAL (P<0.05). Multivariate logistic regression analysis showed that an age of less than 1 year (OR=2.076, P<0.05) or greater than 8 years (OR=1.890, P<0.05), male sex (OR=1.972, P<0.05), incomplete KD (OR=1.426, P<0.05), delayed starting time of IVIG treatment (10 days after onset) (OR=3.251, P<0.05), no response to IVIG (OR=2.301, P<0.05) and fever duration of more than 10 days (OR=1.694, P<0.05) were independent risk factors for the development of CAL, whereas early starting time of IVIG treatment (before 5 days after onset) was a protective factor (OR=0.248, P<0.05). CONCLUSIONS: The occurrence of CAL is associated with many factors in children with KD. Age of less than 1 year or greater than 8 years, male sex, incomplete KD, delayed IVIG treatment after onset, no response to IVIG treatment and prolonged fever duration have been identified as risk factors for the development of CAL.
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LI Yan
WANG Xian-Min
LIU Yi-Ling
SHI Kun
YANG Yan-Feng
GUO Yong-Hong
Key wordsKawasaki disease      Coronary artery lesions      Intravenous immunoglobulin      Corticosteroid      Child     
    
PACS: R725.4  
Cite this article:   
LI Yan,WANG Xian-Min,LIU Yi-Ling et al. Risk factors for coronary artery lesions in children with Kawasaki disease[J]. 中国当代儿科杂志, 2012, 14(12): 938-941.
LI Yan,WANG Xian-Min,LIU Yi-Ling et al. Risk factors for coronary artery lesions in children with Kawasaki disease[J]. CJCP, 2012, 14(12): 938-941.
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