Abstract Objective To study the association between rs1079595 polymorphisms in the DRD2 gene and the distractibility in school-age children. Methods The genotyping at rs1079595 was performed and the distractibility was measured based on the temperament questionnaire in 120 8-12 years old school-age children in order to analyze the effects of the rs1079595 polymorphism and its interaction with the gender, age and delivery mode on the distractibility. Results There was an association between the distractibility and rs1079595 polymorphisms. The distractibility score in children with GG/GT genotypes was significantly higher than in children with the TT genotype (4.3±0.6 vs 4.0±0.7; P<0.05). The interaction between rs1079595 polymorphisms and the delivery mode produced an effect on the distractibility. The normal delivery children with T alleles were associated with a low distractibility (OR=0.037, P<0.01). Conclusions The distractibility based the temperament might be influenced by the rs1079595 polymorphism and its interaction with the delivery mode in school-age children.
About author:: 10.7499/j.issn.1008-8830.2015.03.015
Cite this article:
Enhebayaer,LI Yu-Ling,GUAN Hong-Yan et al. Association between rs1079595 polymorphisms in the DRD2 gene and the distractibility based the temperament in school-age children[J]. CJCP, 2015, 17(3): 270-274.
Enhebayaer,LI Yu-Ling,GUAN Hong-Yan et al. Association between rs1079595 polymorphisms in the DRD2 gene and the distractibility based the temperament in school-age children[J]. CJCP, 2015, 17(3): 270-274.
Cyphers LH, Phillips K, Fulker DW, et al. Twin temperament during the transition from infancy to early childhood[J]. J Am Acad Child Adoles Psychiatry, 1990, 29(3): 392-397.
Comings DE, Wu S, Chiu C, et al. Polygenetic inheritance of Tourette syndrome stuttering, attention deficit hyperiactivity, conduct and oppositional defiant disorder: The additive and subtractive effect of the three dopaminergic genes: D2DR, DβH and DAT1 [J]. Am J Med Genet, 1996, 67(3): 264-288.
3.0.CO;2-N target="_blank">
[6]
Wiebe SA, Espy KA, Stopp C, et al. Gene-environment interactions across development: Exploring DRD2 genotype and prenatal smoking effects on self-regulation [J]. Dev Psychol, 2009, 45(1): 31-44.
[7]
Felten A, Montag C, Kranczioch C. The DRD2 C957T polymorphism and the attentional blink: a genetic association study[J]. Eur Neuropsychopharm, 2013, 23(8): 941-947.
Smillie LD, Cooper AJ, Proitsi P, et al. Variation in DRD2 dopamine gene predicts extraverted personality[J]. Neurosci Lett, 2010, 468(3): 234-237.
[12]
Cohen MX, Young J, Baek JM, et al. Individual differences in extraversion and dopamine genetics predict neural reward responses [J]. Cognit Brain Res, 2005, 25(3): 851-861.
[13]
Noble EP, Ozkaragoz TZ, Ritchie TL, et al. D2 and D4 dopamine receptor polymorphisms and personality[J]. Am J Med Genet, 1998, 81(3): 257-267.
3.0.CO;2-E target="_blank">
[14]
Conner BT, Noble EP, Berman SM, et al. DRD2 genotypes and substance use in adolescent children of alcoholics[J]. Drug Alcohol Depend, 2005, 79(3): 379-387.
[15]
Mehić-Basara N, Oruč L, Kapur-Pojskić L, et al. Association of dopamine receptor gene polymorphism and psychological personality traits in liability for opioid addiction[J]. Bosn J Basic Med Sci, 2013, 13(3): 158-162.
Nyman ES, Loukola A, Varilo T, et al. Sex-specific influence of DRD2 on ADHD-type temperament in a large population-based birth cohort[J]. Psych Genet, 2012, 22 (4): 197-201.
[18]
Dragan WL, Oniszczenko W, Czerski PM, et al. Dopamine genes and sensory sensitivity as a temperamental trait: A familybased association study[J]. J Individual Differences, 2012, 33(4): 205-211.
