Abstract With the increase of the incidence of pre-pregnancy diabetes mellitus and gestational diabetes mellitus, the number of infants of diabetic mothers (IDMs) are increasing year by year. IDMs may be associated with poor perinatal outcomes and may have a negative impact on neurodevelopment, but there are relatively few studies on the neurodevelopmental outcomes of IDMs. This article reviews the relevant literature and summarizes the neurodevelopmental outcomes of IDMs from the aspects of sensory and perception, motor, language, intellectual development, neuropsychiatric disorders, neurological examination and drug effect, so as to provide reference for clinical work. Citation:
Xu TT, Faleschini S, Rifas-Shiman SL, et al. Maternal glucose tolerance in pregnancy and child cognitive and behavioural problems in early and mid-childhood[J]. Paediatr Perinat Epidemiol, 2021, 35(1): 109-119. PMID: 32885485. PMCID: PMC7877074. DOI: 10.1111/ppe.12710.
Shorer DT, Wainstock T, Sheiner E, et al. Long-term endocrine outcome of small for gestational age infants born to mothers with and without gestational diabetes mellitus[J]. Gynecol Endocrinol, 2019, 35(11): 1003-1009. PMID: 31117838. DOI: 10.1080/09513590.2019.1616174.
Kong LH, Nilsson IAK, Brismar K, et al. Associations of different types of maternal diabetes and body mass index with offspring psychiatric disorders[J]. JAMA Netw Open, 2020, 3(2): e1920787. PMID: 32031649. DOI: 10.1001/jamanetworkopen.2019.20787.
Shah R, Harding J, Brown J, et al. Neonatal glycaemia and neurodevelopmental outcomes: a systematic review and meta-analysis[J]. Neonatology, 2019, 115(2): 116-126. PMID: 30408811. DOI: 10.1159/000492859.
Walter E, Tsumi E, Wainstock T, et al. Maternal gestational diabetes mellitus: is it associated with long-term pediatric ophthalmic morbidity of the offspring?[J]. J Matern Fetal Neonatal Med, 2019, 32(15): 2529-2538. PMID: 29429374. DOI: 10.1080/14767058.2018.1439918.
Zacche Sa A, Silva JRJ, Alves JG. Facial responses to basic tastes in the newborns of women with gestational diabetes mellitus[J]. J Matern Fetal Neonatal Med, 2015, 28(14): 1687-1690. PMID: 25212980. DOI: 10.3109/14767058.2014.964680.
Dugas C, Perron J, Marc I, et al. Association between early introduction of fruit juice during infancy and childhood consumption of sweet-tasting foods and beverages among children exposed and unexposed to gestational diabetes mellitus in utero[J]. Appetite, 2019, 132: 190-195. PMID: 30171916. DOI: 10.1016/j.appet.2018.08.033.
Arabiat D, Jabery MA, Kemp V, et al. Motor developmental outcomes in children exposed to maternal diabetes during pregnancy: a systematic review and meta-analysis[J]. Int J Environ Res Public Health, 2021, 18(4): 1699. PMID: 33578786. PMCID: PMC7916519. DOI: 10.3390/ijerph18041699.
Su CH, Liu TY, Chen IT, et al. Correlations between serum BDNF levels and neurodevelopmental outcomes in infants of mothers with gestational diabetes[J]. Pediatr Neonatol, 2021, 62(3): 298-304. PMID: 33753004. DOI: 10.1016/j.pedneo.2020.12.012.
Fraser A, Nelson SM, Macdonald-Wallis C, et al. Associations of existing diabetes, gestational diabetes, and glycosuria with offspring IQ and educational attainment: the avon longitudinal study of parents and children[J]. Exp Diabetes Res, 2012, 2012: 963735. PMID: 22927834. PMCID: PMC3425081. DOI: 10.1155/2012/963735.
Heldarskard GF, Spangmose AL, Henningsen AA, et al. Academic performance in adolescents born to mothers with gestational diabetes—a national Danish cohort study[J]. J Clin Endocrinol Metab, 2021. PMID: 34156463. DOI: 10.1210/clinem/dgab451. Epub ahead of print.
Kong LH, Norstedt G, Schalling M, et al. The risk of offspring psychiatric disorders in the setting of maternal obesity and diabetes[J]. Pediatrics, 2018, 142(3): e20180776. PMID: 30093539. DOI: 10.1542/peds.2018-0776.
Kollins SH, DeLoss DJ, Ca?adas E, et al. A novel digital intervention for actively reducing severity of paediatric ADHD (STARS-ADHD): a randomised controlled trial[J]. Lancet Digit Health, 2020, 2(4): e168-e178. PMID: 33334505. DOI: 10.1016/S2589-7500(20)30017-0.
Guo D, Ju R, Zhou QF, et al. Association of maternal diabetes with attention deficit/hyperactivity disorder (ADHD) in offspring: a meta-analysis and review[J]. Diabetes Res Clin Pract, 2020, 165: 108269. PMID: 32535117. DOI: 10.1016/j.diabres.2020.108269.
Herscu P, Handen BL, Arnold LE, et al. The SOFIA study: negative multi-center study of low dose fluoxetine on repetitive behaviors in children and adolescents with autistic disorder[J]. J Autism Dev Disord, 2020, 50(9): 3233-3244. PMID: 31267292. DOI: 10.1007/s10803-019-04120-y.
Valeri G, Casula L, Menghini D, et al. Cooperative parent-mediated therapy for Italian preschool children with autism spectrum disorder: a randomized controlled trial[J]. Eur Child Adolesc Psychiatry, 2020, 29(7): 935-946. PMID: 31549310. DOI: 10.1007/s00787-019-01395-5.
Hvelplund C, Hansen BM, Koch SV, et al. Perinatal risk factors for feeding and eating disorders in children aged 0 to 3 years[J]. Pediatrics, 2016, 137(2): e20152575. PMID: 26764360. DOI: 10.1542/peds.2015-2575.
Malkar MB, Viswanathan SK, Jadcherla SR. Pilot study of pharyngoesophageal dysmotility mechanisms in dysphagic infants of diabetic mothers[J]. Am J Perinatol, 2019, 36(12): 1237-1242. PMID: 30577057. DOI: 10.1055/s-0038-1676632.
32 Viswanathan S, Batchu S, Osborn E, et al. Diagnostic utility of impedance-pH monitoring in infants of diabetic mothers with oral feeding difficulties[J]. J Perinatol, 2020. PMID: 32981928. DOI: 10.1038/s41372-020-00832-7. Epub ahead of print.
Yuan JY, Wang J, Ma JQ, et al. Paediatric cerebral palsy prevalence and high-risk factors in Henan province, central China[J]. J Rehabil Med, 2019, 51(1): 47-53. PMID: 30299526. DOI: 10.2340/16501977-2486.
Str?m MS, Toll?nes MC, Wilcox AJ, et al. Maternal chronic conditions and risk of cerebral palsy in offspring: a national cohort study[J]. Pediatrics, 2021, 147(3): e20201137. PMID: 33602799. DOI: 10.1542/peds.2020-1137.
Avci R, Whittington JR, Blossom SJ, et al. Studying the effect of maternal pregestational diabetes on fetal neurodevelopment using magnetoencephalography[J]. Clin EEG Neurosci, 2020, 51(5): 331-338. PMID: 32157908. PMCID: PMC8232045. DOI: 10.1177/1550059420909658.
Léveillé P, Hamel M, Ardilouze JL, et al. Pilot study of EEG in neonates born to mothers with gestational diabetes mellitus[J]. Int J Dev Neurosci, 2018, 66: 37-44. PMID: 29360555. DOI: 10.1016/j.ijdevneu.2018.01.003.
Xuan DS, Zhao X, Liu YC, et al. Brain development in infants of mothers with gestational diabetes mellitus: a diffusion tensor imaging study[J]. J Comput Assist Tomogr, 2020, 44(6): 947-952. PMID: 33196602. DOI: 10.1097/RCT.0000000000001110.
Xu Q, Xie QL. Long-term effects of prenatal exposure to metformin on the health of children based on follow-up studies of randomized controlled trials: a systematic review and meta-analysis[J]. Arch Gynecol Obstet, 2019, 299(5): 1295-1303. PMID: 30953188. DOI: 10.1007/s00404-019-05124-w.