振幅整合脑电图联合头颅磁共振定量指标对中晚期早产儿近期神经发育预测价值的前瞻性研究

doi:10.7499/j.issn.1008-8830.2106077

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Abstract Objective To study the association of amplitude-integrated electroencephalogram (aEEG) and the quantitative indices biparietal width (BPW) and interhemispheric distance (IHD) of cranial magnetic resonance imaging (cMRI) with short-term neurodevelopment in moderately and late preterm infants. Methods A total of 104 moderately and late preterm infants who were admitted to the neonatal intensive care unit from September 2018 to April 2020 were selected as the subjects for this prospective study. The Naqeeb method and sleep-wake cycling (SWC) were used for aEEG assessment within 72 hours after birth. cMRI was performed at the corrected gestational age of 37 weeks. BPW and IHD were measured at the T2 coronal position. At the corrected age of 6 months, the Developmental Screening Test for Child Under Six (DST) was used to follow up neurodevelopment. According to developmental quotient (DQ), the infants were divided into a normal DST group (78 infants with DQ≥85) and an abnormal DST group (26 infants with DQ<85). Related indices were compared between the two groups. The association between aEEG and cMRI was evaluated. Results Compared with the normal DST group, the abnormal DST group had significantly lower aEEG normal rate and SWC maturation rate (P<0.05), as well as a significantly larger IHD and a significantly smaller BPW (P<0.05). Immature SWC, aEEG abnormality, and a relatively large IHD were the risk factors for abnormal DST (P<0.05), and a relatively large BPW was a protective factor against abnormal DST (P<0.05). Conclusions For moderately and late preterm infants, aEEG within 72 hours after birth and the quantitative indices BPW and IHD of cMRI at the corrected gestational age of 37 weeks may affect their neurodevelopmental outcome at the corrected age of 6 months.

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	SHEN Lu
	TAO Ming-Yu
	SHI Yu-Xuan
	YIN Jing
	YIN Qi-Gai

Key words： Amplitude-integrated electroencephalogram Magnetic resonance imaging Neurodevelopmental outcome Preterm infant

Received: 18 June 2021

Cite this article:

SHEN Lu,TAO Ming-Yu,SHI Yu-Xuan et al. Value of amplitude-integrated electroencephalogram combined with quantitative indices of cranial magnetic resonance imaging in predicting short-term neurodevelopment in moderately and late preterm infants: a prospective study[J]. CJCP, 2021, 23(10): 987-993.

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http://www.zgddek.com/EN/10.7499/j.issn.1008-8830.2106077 OR http://www.zgddek.com/EN/Y2021/V23/I10/987

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