益生菌联合应用行为分析法治疗儿童孤独症谱系障碍的前瞻性随机对照研究

doi:10.7499/j.issn.1008-8830.2108085

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Abstract Objective To study the effect of probiotics combined with applied behavior analysis (ABA) in the treatment of children with autism spectrum disorder (ASD). Methods A total of 41 children with ASD who attended the Affiliated Hospital of Jiangsu University from May 2019 to December 2020 were enrolled and randomly divided into an observation group with 21 children and a control group with 20 children. The children in the observation group were given oral probiotics combined with ABA intervention, while those in the control group were given ABA intervention alone. The treatment outcomes were compared between the two groups. Autism Treatment Evaluation Checklist (ATEC) was used to evaluate the severity of behavioral symptoms in both groups before intervention and at 3 months after intervention. The fecal samples were collected to analyze the difference in intestinal flora between the two groups based on 16s rRNA high-throughput sequencing. Results Before intervention, there was no significant difference in the ATEC score between the observation and control groups (P>0.05). At 3 months after intervention, both groups had a significant reduction in the ATEC score, and the observation group had a significantly lower ATEC score than the control group (P<0.05). Before intervention, there was no significant difference in the composition of intestinal flora between the observation and control groups. At 3 months after intervention, there was a significant difference in the composition of intestinal flora between the observation and control groups. Compared with the control group, the observation group had significantly higher relative abundances of Bifidobacterium, Lactobacillus, Coprobacillus, Ruminococcus, Prevotella, and Blautia (P<0.05) and significantly lower relative abundances of Shigella and Clostridium (P<0.05). Conclusions Probiotics may improve the effect of conventional ABA intervention in children with ASD by regulating intestinal flora. Citation:

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	Articles by authors
	LI Yu-Qin
	SUN Ying-Hong
	LIANG Ya-Peng
	ZHOU Fan
	YANG Jie
	JIN Sheng-Li

Key words： Autism spectrum disorder Probiotics Applied behavior analysis Child

Received: 18 August 2021

Cite this article:

LI Yu-Qin,SUN Ying-Hong,LIANG Ya-Peng et al. Effect of probiotics combined with applied behavior analysis in the treatment of children with autism spectrum disorder: a prospective randomized controlled trial[J]. CJCP, 2021, 23(11): 1103-1110.

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http://www.zgddek.com/EN/10.7499/j.issn.1008-8830.2108085 OR http://www.zgddek.com/EN/Y2021/V23/I11/1103

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