托法替尼在儿童风湿性疾病中的研究进展

doi:10.7499/j.issn.1008-8830.2201081

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Abstract Tofacitinib is a Janus kinase inhibitor and can block the Janus kinase-signal transducer and activator of transcription signal transduction pathway and reduce the production and release of a variety of cytokines. It has great potential in the treatment of various rheumatic diseases with a rapid onset of action and can reduce corticosteroid dependence and related adverse events. The therapeutic effect of tofacitinib in adult patients has been confirmed, and it has been increasingly used in pediatric patients in recent years. This article reviews the clinical application of tofacitinib in the treatment of pediatric autoimmune diseases.

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	ZHOU Shi-Hai
	XIONG Ya-Qun
	CHEN Ya

Key words： Rheumatic disease Janus kinase-signal transducer and activator of transcription signaling pathway Tofacitinib Child

Received: 20 January 2022

Cite this article:

ZHOU Shi-Hai,XIONG Ya-Qun,CHEN Ya. Recent research on tofacitinib in the treatment of pediatric rheumatic diseases[J]. CJCP, 2022, 24(4): 447-453.

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http://www.zgddek.com/EN/10.7499/j.issn.1008-8830.2201081 OR http://www.zgddek.com/EN/Y2022/V24/I4/447

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