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CJCP  2024, Vol. 26 Issue (1): 42-47    DOI: 10.7499/j.issn.1008-8830.2308119
CLINICAL RESEARCH Current Issue| Next Issue| Archive| Adv Search  | 
Clinical characteristics and prognosis of children with perianal fistulizing Crohn's disease
FANG You-Hong, LUO You-You, ZHANG Rui-Fang, CHENG Qi, CHEN Jie
Department of Gastroenterology, Children's Hospital, Zhejiang University School of Medicine/National Clinical Research Center for Child Health/National Children's Regional Medical Center, Hangzhou 310052, China (Chen J, Email: 6185020@zju.edu.cn)
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Abstract  Objective To investigate the clinical characteristics, treatment, and prognosis of children with perianal fistulizing Crohn's disease (pfCD). Methods A retrospective analysis was conducted on the children, aged 6-17 years, who were diagnosed with Crohn's disease (CD) from April 2015 to April 2023. According to the presence or absence of perianal fistulizing lesions, they were divided into two groups: pfCD (n=60) and non-pfCD (n=82). The two groups were compared in terms of clinical characteristics, treatment, and prognosis. Results The incidence of pfCD was 42.3% (60/142). The proportion of males in the pfCD group was higher than that in the non-pfCD group. Compared with the non-pfCD group, the pfCD group had a significantly higher proportion of children with involvement of the colon and small intestine or those with upper gastrointestinal lesions (P<0.05). Compared with the non-pfCD group, the pfCD group had a significantly higher rate of use of infliximab during both induction and maintenance treatment (P<0.05). In the pfCD group, the children with complex anal fistula accounted for 62% (37/60), among whom the children receiving non-cutting suspended line drainage accounted for 62% (23/37), which was significantly higher than the proportion among the children with simple anal fistula patients (4%, 1/23) (P<0.05). There were no significant differences between the two groups in mucosal healing rate and clinical remission rate at week 54 of treatment (P>0.05). The pfCD group achieved a fistula healing rate of 57% (34/60) at week 54, and the children with simple anal fistula had a significantly higher rate than those with complex anal fistula (P<0.05). Conclusions There is a high incidence rate of pfCD in children with CD, and among the children with pfCD, there is a high proportion of children with the use of biological agents. There is a high proportion of children receiving non-cutting suspended line drainage among the children with complex anal fistula. The occurrence of pfCD should be closely monitored during the follow-up in children with CD.
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FANG You-Hong
LUO You-You
ZHANG Rui-Fang
CHENG Qi
CHEN Jie
Key words： Crohn's disease      Perianal fistulizing Crohn's disease      Clinical characteristic      Treatment      Child     
Received: 31 August 2023     
Cite this article:   
FANG You-Hong,LUO You-You,ZHANG Rui-Fang et al. Clinical characteristics and prognosis of children with perianal fistulizing Crohn's disease[J]. CJCP, 2024, 26(1): 42-47.
FANG You-Hong,LUO You-You,ZHANG Rui-Fang et al. Clinical characteristics and prognosis of children with perianal fistulizing Crohn's disease[J]. CJCP, 2024, 26(1): 42-47.
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