目的 建立新生儿生后不同时间段的超声心动图右心功能参数参考范围，为危重新生儿精准血流动力学评估及临床救治提供依据。 方法 前瞻性收集2023年6月—2024年5月在重庆医科大学附属儿童医院、宁夏回族自治区银川市第一人民医院、内蒙古自治区妇幼保健院3个中心门诊或新生儿科住院的406例足月新生儿的临床数据和超声心动图资料。采用床旁超声心动图测量右心功能参数，采用Spearman秩相关分析各参数与性别、出生体重、胎龄、生后日龄的相关性。采用95%置信区间的方法建立新生儿生后第1、3、7、14和28天超声心动图参考范围，并按胎龄和出生体重分层。 结果 右心功能各参数中，右心室面积变化分数、三尖瓣环收缩期位移、三尖瓣环收缩期峰值速度S'与胎龄及出生体重呈正相关（均P<0.05）。右心室面积变化分数、三尖瓣环收缩期位移、右室流出道速度时间积分、三尖瓣环收缩期峰值速度S'、三尖瓣舒张期血流速度E峰、三尖瓣血流速度E/A比值以及三尖瓣环侧壁舒张早期峰速度e'均与生后日龄呈正相关（均P<0.05）。所有右心功能参数与性别均无相关性（均P>0.05）。按胎龄和出生体重进行分层，建立了生后第1、3、7、14和28天的右心功能参数参考范围。 结论 新生儿右心室收缩及舒张功能的多项参数均与出生后日龄、胎龄及出生体重存在相关性。该研究建立的覆盖全面且分层细化的右心功能评估参数参考范围，可为危重新生儿血流动力学的精细化评估与管理提供重要参考。

Objective To establish reference ranges for right ventricular functional parameters at defined postnatal time points in neonates, thereby providing a basis for precise hemodynamic assessment and clinical management of critically ill neonates. Methods In a prospective multicenter observational study, clinical and echocardiographic data were collected from 406 term neonates who were admitted to neonatal departments or seen in outpatient clinics of three centers (Children's Hospital of Chongqing Medical University, Yinchuan First People's Hospital, and Inner Mongolia Maternal and Child Health Care Hospital) between June 2023 and May 2024. Bedside echocardiography was used to measure right ventricular functional parameters. Spearman rank correlation was applied to assess associations between each parameter and sex, birth weight, gestational age, and postnatal age. Reference ranges were constructed using the 95% confidence interval approach for postnatal days 1, 3, 7, 14, and 28, with stratification by gestational age and birth weight. Results Among the right ventricular functional parameters, right ventricular fractional area change (RV-FAC), tricuspid annular plane systolic excursion (TAPSE), and tricuspid annular peak systolic velocity were positively correlated with gestational age and birth weight (all P<0.05). RV-FAC, TAPSE, right ventricular outflow tract velocity-time integral, tricuspid annular peak systolic velocity, tricuspid inflow E-wave peak velocity, tricuspid inflow E/A ratio, and peak early diastolic velocity of the lateral tricuspid annulus (e') were positively correlated with postnatal age (all P<0.05). None of the right ventricular parameters was correlated with sex (all P>0.05). Reference ranges for postnatal days 1, 3, 7, 14, and 28 were established with stratification by gestational age and birth weight. Conclusions Multiple parameters of neonatal right ventricular systolic and diastolic function are associated with postnatal age, gestational age, and birth weight. The comprehensive, stratified reference ranges for right ventricular functional parameters established in this study may serve as an important reference for refined hemodynamic assessment and management in critically ill neonates.