PDF(537 KB)
PDF(537 KB)
PDF(537 KB)
早产儿生长迟缓与围生期因素的关系研究
Associations between growth retardation and perinatal factors in preterm infants
目的 分析早产儿生长迟缓与围生期因素的关系。 方法 回顾性收集2018年1月—2025年12月武汉大学人民医院儿科儿童健康管理系统中的1 313例(共计3 228例次)2岁以下早产儿的身长数据资料。对不同围生期因素组的身长水平进行比较,分析早产儿生长迟缓与围生期因素的关系。 结果 不同性别、胎龄、出生体重、胎龄别体重的早产儿身长水平比较,差异有统计学意义(P<0.05)。早产儿生长迟缓率为29.77%(961/3 228)。多因素logistic逐步回归分析显示,胎龄≥32周、出生体重≥1 000 g、女性、轻度出生窒息史、母亲分娩年龄≥35岁是早产儿生长迟缓的保护因素(P<0.05)。 结论 早产儿生长迟缓受胎龄、出生体重、性别、母亲分娩年龄等多种围生期因素的影响,需制定早产儿个体化管理策略。
Objective To explore associations between growth retardation and perinatal factors in preterm infants. Methods Length data of 3 228 measurements from 1 313 preterm infants aged under 2 years of age were retrospectively collected from the Child Health Management System of the Department of Pediatrics, Renmin Hospital of Wuhan University, between January 2018 and December 2025. Length was compared across groups stratified by perinatal factors. Associations between perinatal factors and growth retardation were analyzed. Results Significant differences in length were found among subgroups stratified by sex, gestational age, birth weight, and weight-for-gestational age (P<0.05). The prevalence of growth retardation was 29.77% (961/3 228). Stepwise multivariable logistic regression identified gestational age ≥ 32 weeks, birth weight ≥ 1 000 g, female sex, history of mild birth asphyxia, and maternal age at delivery ≥ 35 years as independent protective factors against growth retardation (P<0.05). Conclusions Growth retardation in preterm infants is influenced by multiple perinatal factors, such as gestational age, birth weight, sex, and maternal age at delivery. Individualized management strategies should be developed for preterm infants.
Growth retardation / Perinatal period / Influencing factor / Preterm infant
| [1] |
|
| [2] |
|
| [3] |
|
| [4] |
宋绮莹, 赵晓丽, 郭玉琴, 等. 早产儿校正24月龄内生长轨迹研究[J]. 中国当代儿科杂志, 2021, 23(12): 1200-1207. PMCID: PMC8690708. DOI: 10.7499/j.issn.1008-8830.2108129 .
|
| [5] |
王卫平. 儿科学[M]. 8版. 北京: 人民卫生出版社, 2013.
|
| [6] |
霍亭竹, 毛萌. 儿童体格生长评价相关问题[J]. 中华儿科杂志, 2019, 57(2): 158-160. DOI: 10.3760/cma.j.issn.0578-1310.2019.02.021 .
|
| [7] |
World Health Organization. WHO child growth standards: length/height-for-age, weight-for-age, weight-for-length, weight-for-height and body mass index-for-age: methods and development[EB/OL]. (2006-11-11)[2026-01-28].
|
| [8] |
|
| [9] |
高洁, 徐雪丽, 徐铣明, 等. 真实世界不同出生体重早产儿体格生长规律的研究[J]. 中华儿科杂志, 2021, 59(8): 665-671. DOI: 10.3760/cma.j.cn112140-20210204-00106 .
|
| [10] |
田云芳, 李海欣, 王淮燕. 极早产儿校正0~24月龄追赶生长模式组基轨迹模型分析[J]. 中华新生儿科杂志(中英文), 2025, 40(12): 716-722. DOI: 10.3760/cma.j.cn101451-20250512-00172 .
|
| [11] |
于彦红, 张秋雨, 刘源瀛, 等. 妊娠期危险因素及生后养育方式对早产儿校正24月龄体重的影响研究[J]. 中国生育健康杂志, 2025, 36(6): 543-549. DOI: 10.3969/j.issn.1671-878X.2025.06.007 .
|
| [12] |
|
| [13] |
张梅, 匡晓妮, 缪丹, 等. 不同出生体重早产儿2岁内追赶生长特征的纵向研究[J]. 中国儿童保健杂志, 2022, 30(10): 1136-1140. DOI: 10.11852/zgetbjzz2021-1568 .
|
| [14] |
|
| [15] |
李晓强, 王利霞, 沈玮, 等. 早产儿出生后1年生长速度及影响因素分析[J]. 中国妇幼保健, 2024, 39(1): 93-96. DOI: 10.19829/j.zgfybj.issn.1001-4411.2024.01.025 .
|
| [16] |
|
| [17] |
|
| [18] |
李佳美, 谢群英, 文羽祺, 等. 早产小于胎龄儿校正0~24月龄追赶生长的纵向研究[J]. 中国当代儿科杂志, 2024, 26(1): 72-80. PMCID: PMC10817744. DOI: 10.7499/j.issn.1008-8830.2307059 .
|
| [19] |
|
| [20] |
|
| [21] |
|
所有作者声明不存在利益冲突。