代谢组学在儿童便秘发病机制及治疗中的研究进展

陈小龙; 江米足

doi:10.7499/j.issn.1008-8830.2603081

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中国当代儿科杂志 ›› 2026, Vol. 28 ›› Issue (8) : 1031-1036. DOI: 10.7499/j.issn.1008-8830.2603081

综述

代谢组学在儿童便秘发病机制及治疗中的研究进展

陈小龙 ¹ (综述) ,
江米足 ² (审校)

作者信息 +

Research progress of metabolomics in the pathogenesis and treatment of constipation in children

Xiao-Long CHEN ¹ ,
Mi-Zu JIANG ²

Author information +

文章历史 +

摘要

儿童便秘是一种常见的消化系统功能性疾病，严重影响患儿的生活质量和身心健康。传统的研究方法存在局限性，难以全面阐明其复杂病因及个体差异。近年来，代谢组学作为系统生物学的重要分支，通过对体内多种代谢产物的系统性分析，广泛应用于儿童便秘的诊治研究中。该文综述了代谢组学技术在儿童便秘研究中的应用，重点阐述了便秘患儿体内代谢物谱的特征性改变及其相关代谢通路的调控机制，并评估潜在的发病机制和治疗靶点，旨在为儿童便秘的个体化治疗提供理论依据并指明未来研究方向。

Abstract

Constipation in children is a common functional gastrointestinal disorder that seriously affects quality of life and physical and mental health. Traditional research methods have limitations, making it difficult to fully elucidate the complex etiology and individual variability of constipation. In recent years, metabolomics, as an important branch of systems biology, has been widely applied to the study of pediatric constipation by systematic analysis of various metabolites. This review summarizes the application of metabolomics technologies in pediatric constipation research, focusing on characteristic changes in metabolite profiles and regulatory mechanisms of related metabolic pathways in children with constipation, and evaluates potential pathogenic mechanisms and therapeutic targets. It aims to provide a theoretical basis for individualized treatment of pediatric constipation and to point out future research directions.

导出引用

陈小龙, 江米足. 代谢组学在儿童便秘发病机制及治疗中的研究进展[J]. 中国当代儿科杂志. 2026, 28(8): 1031-1036 https://doi.org/10.7499/j.issn.1008-8830.2603081

Xiao-Long CHEN, Mi-Zu JIANG. Research progress of metabolomics in the pathogenesis and treatment of constipation in children[J]. Chinese Journal of Contemporary Pediatrics. 2026, 28(8): 1031-1036 https://doi.org/10.7499/j.issn.1008-8830.2603081

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