早产儿维生素D两种补充方案的疗效对比:前瞻性随机对照研究

马丽, 李媛, 耿立蒙, 周熙惠

中国当代儿科杂志 ›› 2020, Vol. 22 ›› Issue (10) : 1061-1065.

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中国当代儿科杂志 ›› 2020, Vol. 22 ›› Issue (10) : 1061-1065. DOI: 10.7499/j.issn.1008-8830.2005062
论著·临床研究

早产儿维生素D两种补充方案的疗效对比:前瞻性随机对照研究

  • 马丽1,2, 李媛1, 耿立蒙1,3, 周熙惠1
作者信息 +

A comparative analysis of the efficacy of two vitamin D supplementation regimens in preterm infants: a prospective randomized controlled study

  • MA Li1,2, LI Yuan1, GENG Li-Meng1,3, ZHOU Xi-Hui1
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文章历史 +

摘要

目的 探讨不同维生素D补充方案对出生胎龄 < 34周早产儿生后第28天维生素D营养状况的影响。方法 将59例2018年10月至2019年10月出生胎龄 < 34周的住院早产儿随机分为肌注组(n=30)和口服组(n=29)。肌注组单次肌内注射维生素D3注射液(10 000 IU/kg),口服组口服维生素D3滴剂(900 IU/d),持续25 d。采集两组患儿生后48 h内(维生素D3补充前)及第28天静脉血,检测血清25-羟维生素D[25(OH) D]水平。结果 生后48 h内,59例早产儿维生素D缺乏(≤15 ng/mL)率为78%;两组血清25(OH) D水平及维生素D缺乏率比较差异无统计学意义(P > 0.05)。生后第28天,肌注组血清25(OH) D水平显著高于口服组(P < 0.05),肌注组维生素D缺乏率显著低于口服组(P < 0.05),且无维生素D过量或中毒病例。结论 单次肌内注射10 000 IU/kg维生素D3可显著提升出生胎龄 < 34周早产儿生后第28天血清25(OH) D水平,且能安全并有效地降低维生素D缺乏率。

Abstract

Objective To study the effect of different vitamin D supplementation regimens on the nutritional status of vitamin D on day 28 after birth in preterm infants with a gestational age of < 34 weeks. Methods A total of 59 preterm infants with a gestational age of < 34 weeks who were born from October 2018 to October 2019 were enrolled and divided into an observation group with 30 infants and a control group with 29 infants. The infants in the observation group received a single-dose intramuscular injection of vitamin D3 (10 000 IU/kg), while those in the control group received oral vitamin D3 drops (900 IU/d) for 25 days. Venous blood samples were collected within 48 hours after birth (before vitamin D3 supplementation) and on day 28 after birth to measure the serum 25-hydroxyvitamin D[25(OH)D] level. Results Within 48 hours after birth, the prevalence rate of vitamin D deficiency (≤ 15 ng/mL) was 78% among the 59 preterm infants. There were no significant differences in the serum 25(OH)D level and the prevalence rate of vitamin D deficiency between the two groups (P > 0.05). Compared with the control group on day 28 after birth, the observation group had a significantly higher serum 25(OH)D level (P < 0.05) and a significantly lower prevalence rate of vitamin D deficiency (P < 0.05). There were no cases of vitamin D overdose or poisoning. Conclusions In preterm infants with a gestational age of < 34 weeks, single-dose intramuscular injection of 10 000 IU/kg vitamin D3 can significantly increase serum 25(OH)D level on day 28 after birth and safely and effectively reduce the prevalence rate of vitamin D deficiency.

关键词

25-羟维生素D / 维生素D缺乏 / 维生素D补充 / 早产儿

Key words

25-Hydroxyvitamin D / Vitamin D deficiency / Vitamin D supplementation / Preterm infant

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导出引用
马丽, 李媛, 耿立蒙, 周熙惠. 早产儿维生素D两种补充方案的疗效对比:前瞻性随机对照研究[J]. 中国当代儿科杂志. 2020, 22(10): 1061-1065 https://doi.org/10.7499/j.issn.1008-8830.2005062
MA Li, LI Yuan, GENG Li-Meng, ZHOU Xi-Hui. A comparative analysis of the efficacy of two vitamin D supplementation regimens in preterm infants: a prospective randomized controlled study[J]. Chinese Journal of Contemporary Pediatrics. 2020, 22(10): 1061-1065 https://doi.org/10.7499/j.issn.1008-8830.2005062

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