幼儿园儿童肺炎链球菌携带的聚集性及影响因素分析

王旭麟; 陈敏琪; 李文宇; 傅锦坚; 叶小华

doi:10.7499/j.issn.1008-8830.2011078

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中国当代儿科杂志 ›› 2021, Vol. 23 ›› Issue (4) : 363-368. DOI: 10.7499/j.issn.1008-8830.2011078

论著·临床研究

幼儿园儿童肺炎链球菌携带的聚集性及影响因素分析

王旭麟¹, 陈敏琪¹, 李文宇¹, 傅锦坚², 叶小华¹

作者信息 +

Clustering and influencing factors of Streptococcus pneumoniae carriage among kindergarten children

WANG Xu-Lin¹, CEHN Min-Qi¹, LI Wen-Yu¹, FU Jin-Jian², YE Xiao-Hua¹

Author information +

文章历史 +

摘要

目的探讨幼儿园儿童肺炎链球菌携带的聚集性及影响因素，为肺炎链球菌性疾病的预防提供科学依据。方法采用多阶段分层整群抽样的方法，对柳州市1 702名幼儿园儿童进行双侧鼻前庭拭子采样，对其家长进行问卷调查，数据分析采用卡方检验和随机效应logistic回归模型。结果幼儿园儿童鼻部肺炎链球菌携带率为13.16%（224/1 702）。聚集性分析显示：肺炎链球菌携带在班级水平的随机效应具有统计学意义（Z=2.07，P=0.038），组内相关系数为5.9%。随机效应logistic回归分析表明，5~7岁儿童的肺炎链球菌携带风险低于2~< 5岁儿童（OR=0.55，95% CI：0.40~0.76，P=0.001）；同住人口数≥5的儿童的肺炎链球菌携带风险高于同住人口数 < 5的儿童（OR=1.34，95% CI：1.01~1.79，P=0.043）。结论肺炎链球菌携带存在班级水平的聚集性；年龄和同住人口数是儿童肺炎链球菌携带的重要影响因素。

Abstract

Objective To study the clustering and influencing factors of Streptococcus pneumoniae carriage among kindergarten children, and to provide a scientific basis for the prevention of pneumococcal diseases. Methods The multi-stage stratified cluster sampling method was used to collect nasal swabs via the nasal vestibule at both sides from 1 702 kindergarten children in Liuzhou, China. A questionnaire survey was performed on their parents. The chi-square test and the random effects logistic regression analysis were used to analyze data. Results The carriage rate of Streptococcus pneumoniae was 13.16% (224/1 702) among kindergarten children. The clustering analysis showed that the class-level random effect of Streptococcus pneumoniae carriage was statistically significant (Z=2.07, P=0.038), with an intraclass correlation coefficient of 5.9%. The random effects logistic regression analysis showed that the children aged 5-7 years had a lower risk of Streptococcus pneumoniae carriage than those aged 2-< 5 years (OR=0.55, 95%CI:0.40-0.76, P=0.001), and the children with ≥ 5 family members living together had a higher risk of Streptococcus pneumoniae carriage than those with < 5 family members (OR=1.34, 95%CI:1.01-1.79, P=0.043). Conclusions Streptococcus pneumoniae carriage shows a class-level clustering effect, and age and the number of cohabitants are important influencing factors for Streptococcus pneumoniae carriage in children.

导出引用

王旭麟, 陈敏琪, 李文宇, 傅锦坚, 叶小华. 幼儿园儿童肺炎链球菌携带的聚集性及影响因素分析[J]. 中国当代儿科杂志. 2021, 23(4): 363-368 https://doi.org/10.7499/j.issn.1008-8830.2011078

WANG Xu-Lin, CEHN Min-Qi, LI Wen-Yu, FU Jin-Jian, YE Xiao-Hua. Clustering and influencing factors of Streptococcus pneumoniae carriage among kindergarten children[J]. Chinese Journal of Contemporary Pediatrics. 2021, 23(4): 363-368 https://doi.org/10.7499/j.issn.1008-8830.2011078

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