血清维生素D水平与幼龄儿童社区获得性肺炎严重程度及危险因素的相关性研究

任静; 孙斌; 缪珀; 冯星

doi:10.7499/j.issn.1008-8830.2013.07.004

PDF(966 KB)

中国当代儿科杂志 ›› 2013, Vol. 15 ›› Issue (7) : 519-521. DOI: 10.7499/j.issn.1008-8830.2013.07.004

论著·临床研究

血清维生素D水平与幼龄儿童社区获得性肺炎严重程度及危险因素的相关性研究

任静，孙斌，缪珀，冯星

作者信息 +

Correlation between serum vitamin D level and severity of community acquired pneumonia in young children

REN Jing, SUN Bin, MIAO Po, FENG Xing

Author information +

文章历史 +

摘要

目的：探讨幼龄儿童体内血清维生素D水平来分析其与社区获得性肺炎（CAP）严重程度的关系，并探讨CAP的相关危险因素。方法：随机选取2011年10月至2012年4月就诊的CAP患儿103例为研究对象，其中重度CAP患儿15例，轻度CAP患儿88例；另随机选取同期门诊体检的健康儿童90例为正常对照组。采用酶联免疫法测定各组儿童体内25-(OH)D3的水平。结果：重度组患儿血清25-(OH)D3水平显著低于轻度组和对照组（P<0.01），轻度组与对照组之间差异无统计学意义（P=0.674）。多因素回归分析提示25-(OH)D3水平＜50 nmol/L和有早产史是重度CAP发生的独立危险因素。结论：维生素D缺乏可能影响幼龄儿童CAP的严重程度。

Abstract

OBJECTIVE: To study the correlation between serum vitamin D level and severity of community acquired pneumonia (CAP) in young children, and explore related risk factors for CAP. METHODS: One hundred and three children with CAP between October 2011 and April 2012 were enrolled in the study, including 15 cases of severe CAP and 88 cases of mild CAP. Ninety healthy children were used as the control group. 25-(OH)D3 concentrations were measured by enzyme linked immunoassay. RESULTS: The mean vitamin D concentration in the severe CAP group was significantly lower than in the mild CAP and control groups (P<0.01), and there was no significant difference between the mild CAP and control groups (P=0.674). Premature birth and vitamin D＜50 nmol/L were risk factors for severe CAP in the multivariate analysis. CONCLUSIONS: Vitamin D deficiency might be associated with the severity of CAP in young children.

导出引用

任静，孙斌，缪珀，冯星. 血清维生素D水平与幼龄儿童社区获得性肺炎严重程度及危险因素的相关性研究[J]. 中国当代儿科杂志. 2013, 15(7): 519-521 https://doi.org/10.7499/j.issn.1008-8830.2013.07.004

REN Jing, SUN Bin, MIAO Po, FENG Xing. Correlation between serum vitamin D level and severity of community acquired pneumonia in young children[J]. Chinese Journal of Contemporary Pediatrics. 2013, 15(7): 519-521 https://doi.org/10.7499/j.issn.1008-8830.2013.07.004

参考文献

［1］Mulholland K. Magnitude of the problem of childhood pneumonia［J］. Lancet, 1999, 354(9178):590-592.

［2］Cannell JJ, Vieth R, Umhau JC, Holick MF, Grant WB, Madronich S, et al. Epidemic influenza and vitamin D［J］. Epidemiol Infect, 2006, 134(6):1129-1140.

［3］Aloia JF, Li-Ng M. Re: epidemic influenza and vitamin D［J］. Epidemiol Infect, 2007, 135(7):1095-1096.

［4］Mansbach JM, Camargo CA Jr. Bronchiolitis: lingering questions about its definition and the potential role of vitamin D［J］. Pediatrics, 2008, 122(1):177-179.

［5］HopeSimpson RE. The role of season in the epidemiology of influenza［J］. J Hyg (Lond), 1981, 86(1):35-47.

［6］Deluca HF, Cantorna MT. Vitamin D: its role and uses in immunology［J］. FASEB J, 2001, 15(14):2579-2585.

［7］Poon AH, Laprise C, Lemire M, Montpetit A, Sinnett D, Schurr E, et al. Association of vitamin D receptor genetic variants with susceptibility to asthma and atopy［J］. Am J Resp Crit Care, 2004, 170(9):967-973.

［8］中华医学会儿科分会呼吸分组，《中华儿科杂志》编辑委员会. 儿童社区获得性肺炎管理指南（试行）（上）［J］. 中华儿科杂志, 2007, 45(2):83-90.

［9］Yim S, Dhawan P, Ragunath C, Christakos S, Diamond G. Induction of cathelicidin in normal and CF bronchial epithelial cells by 1,25-dihydroxyvitamin D3［J］. J Cyst Fibros, 2007, 6(6):403-410.

［10］Liu PT, Stenger S, Tang DH, Modlin RL. Cutting edge: vitamin D-mediated human antimicrobial activity against Mycobacterium tuberculosis is dependent on the induction of cathelicidin［J］. J Immunol, 2007, 179(4):2060-2063.

［11］Bartley J. Vitamin D, innate immunity and upper respiratory tract infection［J］. J Laryngol Otol, 2010, 124(5):465-469.

［12］Mcnally JD, Leis K, Matheson LA, Karuananyake C, Sankaran K, Rosenberg AM. Vitamin D deficiency in young children with severe acute lower respiratory infection［J］. Pediatr Pulmonol, 2009, 44(10):981-988.

［13］Urashima M, Segawa T, Okazaki M, Kurihara M, Wada Y, Ida H. Randomized trial of vitamin D supplementation to prevent seasonal influenza A in schoolchildren［J］. Am J Clin Nutr, 2010, 91(5):1255-1260.