疑似预防接种异常反应及其与预防接种的因果关系评估

姚开虎; 杨永弘

doi:10.7499/j.issn.1008-8830.2014.01.001

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中国当代儿科杂志 ›› 2014, Vol. 16 ›› Issue (1) : 1-4. DOI: 10.7499/j.issn.1008-8830.2014.01.001

专家讲座

疑似预防接种异常反应及其与预防接种的因果关系评估

姚开虎, 杨永弘

作者信息 +

Adverse events following immunization and causality assessment of an adverse event following immunization

YAO Kai-Hu, YANG Yong-Hong

Author information +

文章历史 +

摘要

2013年12月，媒体报道湖南、广东、四川等地出现接种乙肝疫苗接种后死亡事件，引起社会的普遍关注。当前，疫苗种类和使用的范围、目的更加广泛，临床医生，尤其儿科医生将会面临越来越多的与疫苗有关的临床问题，需要重视学习疫苗学知识。本文介绍了“疑似预防接种异常反应”和“预防接种异常反应”的定义和分类，以及疑似预防接种异常反应与预防接种因果关系评估的意义和结论等有关知识。

Abstract

Several fatal events occurred in Hunan, Guangdong and Sichuan Province in December, 2013. The events were reported by the news media, which followed growing public concern. Currently, more and more vaccines were developed and the immunization was adopted for more objectives. The clinicians, especially pediatricians will face a growing number of clinical problems related to the vaccine. The clinicians should pay attention to learn more knowledge about vaccines. This article describes the definition and classification of "adverse events following immunization" and "serious vaccine product-related reactions", and the signifcance and conclusion of causality assessment following immunization.

导出引用

姚开虎, 杨永弘. 疑似预防接种异常反应及其与预防接种的因果关系评估[J]. 中国当代儿科杂志. 2014, 16(1): 1-4 https://doi.org/10.7499/j.issn.1008-8830.2014.01.001

YAO Kai-Hu, YANG Yong-Hong. Adverse events following immunization and causality assessment of an adverse event following immunization[J]. Chinese Journal of Contemporary Pediatrics. 2014, 16(1): 1-4 https://doi.org/10.7499/j.issn.1008-8830.2014.01.001

参考文献

[1] 新浪网. 两部委回应婴儿接种疫苗后死亡6大质疑[EB/OL].[2013-12-26]. http://news.sina.com.cn/c/2013-12-25/021929072312.shtml.
[2] 新浪网. 官方: 未发现深圳康泰乙肝疫苗存在质量问题[EB/OL]. [2014-1-6]. http://finance.sina.com.cn/stock/y/20140103/124017836087.shtml.
[3] 世界卫生组织. 世卫组织关注和支持对疑似预防接种异常反应的调查[EB/OL]. [2014-1-6]. http://www.wpro.who.int/china/mediacentre/releases/2013/20131227/zh/.
[4] World Health Organization. Causality assessment of an adverse event following immunization (AEFI). User manual for the WHO revised classification [EB/OL]. [2013-12-26]. http://www.who.int/vaccine_safety/publications/gvs_aefi/en/.
[5] 预防接种的反应和分类[M]//谢广中, 刁连东, 王树巧, 等. 预防接种的反应和处理. 第三版.上海: 上海科学技术出版社, 2009: 22-40.
[6] Tozzi AE, Asturias EJ, Balakrishnan MR, et al. Assessment of causality of individual adverse events following immunization (AEFI): a WHO tool for global use[J]. Vaccine, 2013, 31(44): 5041-5046.
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