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百日咳并发症
Complications of pertussis
百日咳感染者可出现多种并发症，常见并发肺炎、球结膜下出血等，严重并发症，如肺动脉高压、脑病等可能危及生命。低年龄患儿缺乏百日咳特征性的临床表现，因此提高对百日咳并发症的认识，有助于及时诊断和治疗百日咳，对改善预后有着积极意义。但目前还没有百日咳并发症的诊治规范，不同报告使用的诊断名称、依据和报告数据等存在很大差异。该文就文献报道的百日咳并发症，包括呼吸系统并发症（肺炎、肺动脉高压、气胸及纵膈或皮下气肿）、骨折、疝气、循环系统并发症、神经系统并发症（惊厥、脑病及出血和血肿）、泌尿系统并发症、继发感染等进行了全面综述，希望为临床诊治和研究百日咳并发症，以及早日促成百日咳并发症的规范诊治提供参考。
Patients with pertussis can have a variety of complications, including pneumonia and subconjunctival hemorrhage. Severe complications, such as pulmonary hypertension and encephalopathy, can be life-threatening. Younger children with pertussis may lack the characteristic clinical manifestations of pertussis, and therefore, a deeper understanding of the complications of pertussis may help to improve the diagnosis, treatment, and prognosis of pertussis. However, there is still no standard for the diagnosis and treatment of pertussis complications, and there are great differences in diagnostic name, basis, and data used in different reports. This article reviews the complications of pertussis which have been reported so far, such as pulmonary complications (pneumonia, pulmonary hypertension, pneumothorax, and mediastinal or subcutaneous emphysema), fractures, hernias, circulatory system complications, nervous system complications (convulsion, encephalopathy, hemorrhage, and hematoma), urinary system complications, and secondary infections, so as to provide a reference for the clinical diagnosis and treatment of pertussis complications, scientific research on pertussis complications, and the promotion of standardized diagnosis and treatment of pertussis complications.
Pertussis / Complication / Diagnosis / Child
[1] Kasper DL, Fauci AS. Harrison's infectious diseases[M]. 第3版(英文版), 北京:北京联合出版公司, 2017:502-506.
[2] Cherry JD. Pertussis in young infants throughout the world[J]. Clin Infect Dis, 2016, 63(Suppl 4):S119-S122.
[3] 赵建刚, 蔡玉香. 新生儿百日咳68例临床分析[J]. 中华新生儿科杂志, 2017, 32(3):201-204.
[4] Berti E, Chiappini E, Orlandini E, et al. Pertussis is still common in a highly vaccinated infant population[J]. Acta Paediatr, 2014, 103(8):846-849.
[5] Aquino-Andrade A, Martinez-Leyva G, Merida-Vieyra J, et al. Real-time polymerase chain reaction-based detection of Bordetella pertussis in mexican infants and their contacts:a 3-year multicenter study[J]. J Pediatr, 2017, 188:217-223.e1.
[6] Rothstein E, Edwards K. Health burden of pertussis in adolescents and adults[J]. Pediatr Infect Dis J, 2005, 24(5 Suppl):S44-S47.
[7] Centers for Disease Control and Prevention (CDC). Pertussis -United States, January 1992-June 1995[J]. MMWR Morb Mortal Wkly Rep, 1995, 44(28):525-529.
[8] Farizo KM, Cochi SL, Zell ER, et al. Epidemiological features of pertussis in the United States, 1980-1989[J]. Clin Infect Dis, 1992, 14(3):708-719.
[9] Serres GD, Shadmani R, Duval B, et al. Morbidity of pertussis in adolescents and adults[J]. J Infect Dis, 2000, 182(1):174-179.
[10] 许美, 雷炎玲, 谭锟, 等. 住院患儿百日咳相关性肺炎309例临床分析[J]. 中华儿科杂志, 2018, 56(9):686-690.
[11] Ayala VI, Teijaro JR, Farber DL, et al. Bordetella pertussis infection exacerbates influenza virus infection through pertussis toxin-mediated suppression of innate immunity[J]. PLoS One, 2011, 6(4):e19016.
[12] 马卓娅, 郑跃杰, 王文建, 等. 142例百日咳患儿合并其他呼吸道病原体情况分析[J]. 国际儿科学杂志, 2017, 44(9):653-656.
[13] 许美. 儿童百日咳并发症的临床分析[D]. 遵义:遵义医学院, 2018.
[14] Nieves DJ, Heininger U. Bordetella pertussis[J]. Microbiol Spectr, 2016, 4(3). doi:10.1128/microbiolspec.EI10-0008-2015.
[15] 郑侠, 董世霄, 齐宇洁, 等. 重症新生儿百日咳五例临床分析[J]. 中华新生儿科杂志, 2017, 32(6):452-455.
[16] Martinez M, Rochat I, Corbelli R, et al. Early blood exchange transfusion in malignant pertussis:a case report[J]. Pediatr Crit Care Med, 2011, 12(2):e107-e109.
[17] Tian SF, Wang HM, Deng JK. Fatal malignant pertussis with hyperleukocytosis in a Chinese infant:a case report and literature review[J]. Medicine, 2018, 97(17):e0549.
[18] Nieves D, Bradley JS, Gargas J, et al. Exchange blood transfusion in the management of severe pertussis in young infants[J]. Pediatr Infect Dis J, 2013, 32(6):698-699.
[19] 项龙, 曹清, 奚悦玲, 等. 白细胞去除术治疗婴儿高白细胞合并肺动脉高压百日咳三例并文献复习[J]. 中国小儿急救医学, 2018, 25(11):801-807.
[20] 魏雪梅, 杨慧, 雷旻, 等. 换血治疗婴儿重症百日咳合并高白细胞血症1例报道[J]. 中国当代儿科杂志, 2019, 21(3):214-217.
[21] Maitre G, Schaffner D, Natterer J, et al. Leukemoid reaction in infant pertussis:is there a place for hydroxyurea? A case report[J]. Front Pediatr, 2018, 6:261.
[22] Monaco F, Barone M, Manfredi VG, et al. Pneumomediastinum as a complication of critical pertussis[J]. Clin Respir J, 2016, 10(6):772-776.
[23] Prasad S, Baur LA. Fracture of the first rib as a consequence of pertussis infection[J]. J Paediatr Child Health, 2001, 37(1):91-93.
[24] Shvartzman P, Mader R, Stopler T. Herniated lumbar disc associated with pertussis[J]. J Fam Pract, 1989, 28(2):224-225.
[25] 米荣, 伏瑾, 王晓颖, 等. 迁延性咳嗽婴幼儿百日咳感染临床情况调查[J]. 中华医学杂志, 2013, 93(22):1721-1725.
[26] Zambrano JA, Herman TN. Rib fracture associated with Bordetella pertussis infection[J]. N Engl J Med, 2018, 378(3):e4.
[27] Viticchi G, Falsetti L, Baruffaldi R, et al. Acute carotid dissection in an adult caused by pertussis[J]. J Stroke Cerebrovasc Dis, 2013, 22(8):e635-e636.
[28] Goulin GD, Kaya KM, Bradley JS. Severe pulmonary hypertension associated with shock and death in infants infected with Bordetella pertussis[J]. Crit Care Med, 1993, 21(11):1791-1794.
[29] Berger JT, Carcillo JA, Shanley TP, et al. Critical pertussis illness in children:a multicenter prospective cohort study[J]. Pediatr Crit Care Med, 2013, 14(4):356-365.
[30] Sanghi V. Neurologic manifestations of diphtheria and pertussis[J]. Handb Clin Neurol, 2014, 121:1355-1359.
[31] 胡云鸽, 刘泉波. 儿童百日咳247例临床特点及重症百日咳危险因素分析[J]. 中华儿科杂志, 2015, 53(9):684-689.
[32] 许美, 王红梅, 雷炎玲, 等. 百日咳脑病患儿八例临床分析[J]. 中华传染病杂志, 2017, 35(7):425-427.
[33] 王晓颖, 米荣, 伏瑾, 等. 2011至2015年59例3月龄以下婴儿百日咳的临床特征分析[J]. 中华围产医学杂志, 2017, 20(8):583-588.
[34] 窦聪, 刘奉琴, 郭春艳, 等. 2012年至2014年百日咳流行特征及住院患者临床特点分析[J]. 中华实用儿科临床杂志, 2016, 31(20):1559-1562.
[35] Mertens PL, Stals FS, Schellekens JF, et al. An epidemic of pertussis among elderly people in a religious institution in The Netherlands[J]. Eur J Clin Microbiol Infect Dis, 1999, 18(4):242-247.
[36] Chaturvedi S, Licht C, Langlois V. Hemolytic uremic syndrome caused by Bordetella pertussis infection[J]. Pediatr Nephrol, 2010, 25(7):1361-1364.
[37] Decherd ME, Deskin RW, Rowen JL, et al. Bordetella pertussis causing otitis media:a case report[J]. Laryngoscope, 2003, 113(2):226-227.
[38] Cherry JD, Paddock CD. Pathogenesis and histopathology of pertussis:implications for immunization[J]. Expert Rev Vaccines, 2014, 13(9):1115-1123.
[39] Sim YB, Park SH, Kim SS, et al. Pertussis toxin administered spinally induces a hypoglycemic effect on normal and diabetic mice[J]. Pharmacology, 2014, 94(1-2):29-40.
[40] Cherry JD, Paddock CD, Greer PW, et al. The respiratory pathology in infants with sudden unexpected deaths in whom respiratory specimens were initially PCR-positive or PCR-negative for Bordetella pertussis[J]. Infection, 2011, 39(6):545-548.
[41] Pellegrino P, Carnovale C, Perrone V, et al. Kawasaki disease and pertussis epidemics[J]. Epidemiology, 2014, 25(2):310-311.
[42] Rubin K, Glazer S. The pertussis hypothesis:Bordetella pertussis colonization in the pathogenesis of Alzheimer's disease[J]. Immunobiology, 2017, 222(2):228-240.
[43] Rubin K, Glazer S. The pertussis hypothesis:Bordetella pertussis colonization in the etiology of asthma and diseases of allergic sensitization[J]. Med Hypotheses, 2018, 120:101-115.
