目的 研究不同诱导缓解方案对克罗恩病（Crohn's disease, CD）患儿营养状况的影响。 方法 回顾性分析2013年1月—2023年5月在浙江大学医学院附属儿童医院接受诱导缓解治疗的188例CD患儿资料，比较糖皮质激素、全肠内营养（exclusive enteral nutrition, EEN）、英夫利西单抗（infliximab, IFX）3种诱导缓解治疗方案对患儿身高、体重、血红蛋白及微量元素等指标的影响。 结果 经诱导缓解治疗，3组患儿的年龄别体重指数Z评分、血红蛋白和白蛋白显著增加（P<0.05），年龄别身高Z评分无变化（P>0.05）。EEN和IFX组叶酸、25羟维生素D、血清铁及血清钙水平提高，血清铜水平下降（P<0.05）。EEN组维生素B₁₂水平改善（P<0.05）。 结论 EEN、激素、IFX均可有效改善CD患儿年龄别体重指数Z评分、血红蛋白水平和白蛋白水平。EEN与IFX在改善25羟维生素D、叶酸、血清铁及血清钙方面优于激素治疗。

Objective To study the impact of different induction remission therapies on the nutritional status of children with Crohn's disease (CD). Methods A retrospective analysis was conducted on the medical data of 188 children with CD who received induction remission therapy at the Children's Hospital, Zhejiang University School of Medicine from January 2013 to May 2023. The effects of three induction remission therapies—exclusive enteral nutrition (EEN), corticosteroids, and infliximab (IFX)—on height, weight, hemoglobin, and trace elements were compared. Results After induction remission therapy, the weight-for-age Z scores and serum levels of hemoglobin and albumin in all three groups significantly increased (P<0.05), while the height-for-age Z scores showed no change (P>0.05). The levels of folic acid, 25-hydroxy vitamin D, serum iron, and total calcium increased, and serum copper levels decreased in the EEN and IFX groups (P<0.05). Vitamin B₁₂ levels improved in the EEN group (P<0.05). Conclusions EEN, corticosteroids, and IFX may effectively improve the weight-for-age Z scores and serum levels of hemoglobin and albumin in children with CD. EEN and IFX seem to be superior to corticosteroid therapy in improving 25-hydroxy vitamin D, folic acid, serum iron, and total calcium levels.