孤独症谱系障碍儿童共患便秘的机制及临床管理的研究进展

丁洁洁; 杜冬月; 黎萍

doi:10.7499/j.issn.1008-8830.2506077

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中国当代儿科杂志 ›› 2025, Vol. 27 ›› Issue (12) : 1549-1555. DOI: 10.7499/j.issn.1008-8830.2506077

综述

孤独症谱系障碍儿童共患便秘的机制及临床管理的研究进展

丁洁洁 ¹ ,
杜冬月 ² (综述) ,
黎萍 ¹ (审校)

作者信息 +

Research progress on mechanisms and clinical management of comorbid constipation in children with autism spectrum disorder

Author information +

文章历史 +

摘要

孤独症谱系障碍（autism spectrum disorder, ASD）儿童常共患胃肠道问题，其中便秘最为普遍。便秘的出现时间、严重程度与ASD的核心症状密切相关，改善ASD患儿的便秘症状可减轻其核心症状。然而，ASD共患便秘的机制尚不明确。ASD共患便秘的多学科评估是其临床管理的基础。针对性的药物治疗、饮食干预、肠道微生态调节，以及补充和替代医学干预等，可作为ASD共患便秘患儿个性化治疗的选择。该文综述了ASD共患便秘的机制、评估和临床管理，旨在为ASD的综合干预提供参考。

Abstract

Children with autism spectrum disorder (ASD) frequently have comorbid gastrointestinal problems, with constipation being the most prevalent. The onset and severity of constipation are closely related to the core symptoms of ASD, and improving constipation can alleviate these core symptoms. However, the mechanisms underlying comorbid constipation in ASD remain unclear. Multidisciplinary assessment is the foundation of clinical management for comorbid constipation in ASD. Targeted pharmacological therapy, dietary interventions, gut microbiota modulation, and complementary and alternative medicine interventions can be chosen for personalized treatment. This review summarizes the mechanisms, assessment, and clinical management of comorbid constipation in ASD and aims to provide a reference for comprehensive interventions in ASD.

导出引用

丁洁洁, 杜冬月, 黎萍. 孤独症谱系障碍儿童共患便秘的机制及临床管理的研究进展[J]. 中国当代儿科杂志. 2025, 27(12): 1549-1555 https://doi.org/10.7499/j.issn.1008-8830.2506077

Jie-Jie DING, Dong-Yue DU, Ping LI. Research progress on mechanisms and clinical management of comorbid constipation in children with autism spectrum disorder[J]. Chinese Journal of Contemporary Pediatrics. 2025, 27(12): 1549-1555 https://doi.org/10.7499/j.issn.1008-8830.2506077

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