肿瘤抑制基因PTEN在脑发育和分化中的作用

李德渊, 屈艺, 母得志

中国当代儿科杂志 ›› 2009, Vol. 11 ›› Issue (02) : 159-161.

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中国当代儿科杂志 ›› 2009, Vol. 11 ›› Issue (02) : 159-161.
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肿瘤抑制基因PTEN在脑发育和分化中的作用

  • 李德渊,屈艺,母得志
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Roles of tumor suppressor PTEN in the development and differentiation of brain

  • LI De-Yuan, QU Yi, MU De-Zhi
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李德渊, 屈艺, 母得志. 肿瘤抑制基因PTEN在脑发育和分化中的作用[J]. 中国当代儿科杂志. 2009, 11(02): 159-161
LI De-Yuan, QU Yi, MU De-Zhi. Roles of tumor suppressor PTEN in the development and differentiation of brain[J]. Chinese Journal of Contemporary Pediatrics. 2009, 11(02): 159-161
中图分类号: R0   

参考文献

[1]Blanco-Aparicio C, Renner O, Leal JF, Carnero A. PTEN, more than the AKT pathway[J]. Carcinogenesis, 2007, 28(7):1379-1386.
[2]Chang N, El-Hayek YH, Gomez E, Wan Q. Phosphatase PTEN in neuronal injury and brain disorders[J]. Trends Neurosci, 2007, 30(11):581-586.
[3]Gericke A, Munson M, Ross AH. Regulation of the PTEN phosphatase[J]. Gene, 2006, 374:1-9.
[4]Greer JM, Wynshaw-Boris A. PTEN and the brain: sizing up social interaction[J]. Neuron, 2006, 50(3):343-345.
[5]Backman SA, Stambolic V, Suzuki A, Haight J, Elia A, Pretorius J, et al. Deletion of PTEN in mouse brain causes seizures, ataxia and defects in soma size resembling Lhermitte-Duclos disease[J]. Nat Genet, 2001, 29(4):396-403.
[6]Li J, Yen C, Liaw D, Podsypanina K, Bose S, Wang SI, et al. PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer[J]. Science, 1997, 275(5308):1943-1947.
[7]Tanriover G, Demir N, Pestereli E, Demir R, Kayisli UA. PTEN-mediated Akt activation inhuman neocortex during prenatal development[J]. Histochem Cell Biol, 2005, 123(4-5):393-406.
[8]Lachyankar MB, Sultana N, Schonhoff CM, Mitra P, Poluha W, Lambert S, et al. A role for nuclear PTEN in neuronal differentiation[J]. J Neurosci, 2000, 20(4):1404-1413.
[9]Loudon RP, Silver LD, Yee HF Jr, Gallo G. RhoA-kinase and myosin II are required for the maintenance of growth cone polarity and guidance by nerve growth factor[J]. J Neurobiol, 2006, 66(8):847-867.
[10]Pasterkamp RJ, Kolk SM, Hellemons AJ, Kolodkin AL. Expression patterns of semaphorin7A and plexinC1 during rat neural development suggest roles in axon guidance and neuronal migration[J]. BMC Dev Biol, 2007, 7:98.
[11]Rajnicek AM, Foubister LE, McCaig CD. Growth cone steering by a physiological electric field requires dynamic microtubules, microfilaments and Rac-mediated filopodial asymmetry[J]. J Cell Sci, 2006 119(Pt 9):1736-1745.
[12]Yoshimura T, Arimura N, Kaibuchi K. Signaling networks in neuronal polarization[J]. J Neurosci, 2006, 26(42):10626-10630.
[13]Arimura N, Kaibuchi K. Key regulators in neuronal polarity[J]. Neuron, 2005, 48(6):881-884.
[14]Watabe-Uchida M, Govek EE, Van Aelst L. Regulators of Rho GTPases in neuronal development[J]. J Neurosci, 2006, 26(42):10633-10635.
[15]Yoshimura T, Kawano Y, Arimura N, Kawabata S, Kikuchi A, Kaibuchi K.GSK-3beta regulates phosphorylation of CRMP-2 and neuronal polarity[J]. Cell, 2005, 120(1):137-149.
[16]Cole AR, Causeret F, Yadirgi G, Hastie CJ, McLauchlan H, McManus EJ, et al. Distinct priming kinases contribute to differential regulation of collapsin response mediator proteins by glycogen synthase kinase-3 in vivo[J]. J Biol Chem, 2006, 281(24):16591-16598.
[17]Jiang H, Guo W, Liang X, Rao Y. Both the establishment and the maintenance of neuronal polarity require active mechanisms: critical roles of GSK-3beta and its upstream regulators[J]. Cell, 2005, 120(1):123-135.
[18]Rossi DJ, Weissman IL. PTEN, tumorigenesis, and stem cell selfrenewal[J]. Cell, 2006, 125(2):229-231.
[19]Groszer M, Erickson R, Scripture-Adams DD, Lesche R, Trumpp A, Zack JA. Negative regulation of neural stem/progenitor cell proliferation by the PTEN tumor suppressor gene in vivo[J]. Science, 2001, 294(5549):2186-2189.
[20]Groszer M, Erickson R, Scripture-Adams DD, Dougherty JD, Le Belle J, Zack JA, et al. PTEN negatively regulates neural stem cell self-renewal by modulating G0-G1 cell cycle entry[J]. Proc Natl Acad Sci USA, 2006, 103(1):111-116.
[21]van Diepen MT, Eickholt BJ. Function of PTEN during the formation and maintenance of neuronal circuits in the brain[J]. Dev Neurosci, 2008, 30(1-3):59-64.
[22]Leslie NR, Yang X, Downes CP, Weijer CJ. The regulation of cell migration by PTEN[J]. Biochem Soc Trans, 2005, 33(Pt 6):1507-1508.
[23]Li L, Liu F, Ross AH. PTEN regulation of neural development and CNS stem cells[J]. J Cell Biochem, 2003, 88(1):24-28.
[24]van Nimwegen MJ, Huigsloot M, Camier A, Tijdens IB, van de Water B. Focal adhesion kinase and protein kinase B cooperate to suppress doxorubicin-induced apoptosis of breast tumor cells[J]. Mol Pharmacol, 2006, 70(4):1330-1339.
[25]Zhao H, Sapolsky RM, Steinberg GK. Phosphoinositide-3-kinase/akt survival signal pathways are implicated in neuronal survival after stroke[J]. Mol Neurobiol, 2006, 34(3):249-270.
[26]Zhu Y, Hoell P, Ahlemeyer B, Sure U, Bertalanffy H, Krieglstein J. Implication of PTEN in production of reactive oxygen species and neuronal death in in-vitro models of stroke and Parkinson′s disease[J]. Neurochem Int, 2007, 50(3):507-516.
[27]Zhang QG, Wu DN, Han D, Zhang GY. Critical role of PTEN in the coupling between PI3K/Akt and JNK1/2 signaling in ischemic brain injury[J]. FEBS Lett, 2007, 581(3):495-505.
[28]Zhu Y, Hoell P, Ahlemeyer B, Krieglstein J. PTEN: a crucial mediator of Mitochondria-dependent apoptosis[J]. Apoptosis, 2006, 11(2):197-207.
[29]Perandones C, Costanzo RV, Kowaljow V, Pivetta OH, Carminatti H, Radrizzani M. Correlation between synaptogenesis and the PTEN phosphatase expression in dendrites during postnatal brain development[J]. Brain Res Mol Brain Res, 2004, 128(1):8-19.
[30]Fraser MM, Bayazitov IT, Zakharenko SS, Baker SJ. Phosphatase and tensin homolog, deleted on chromosome 10 deficiency in brain causes defects in synaptic structure, transmission and plasticity, and myelination abnormalities[J]. Neuroscience, 2008, 151(2):476-488.


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