目的：研究小麦纤维素治疗儿童功能性便秘的有效性和安全性。方法：采用前瞻性自身对照研究方法，对34例功能性便秘的患儿给予小麦纤维素治疗2周，观察治疗前后便秘症状及粪便性状改善情况，并进行量化评分比较。结果：治疗后3 d、7 d和14 d，粪便性状、排便间隔、排便困难积分均明显下降；便秘症状总积分也明显下降，与治疗前比较差异有统计学意义（P<0.05）。治疗后3、7、14 d总有效率分别为37%、87%和90%。医生非常满意和比较满意率为57%，患儿家长非常满意和比较满意率为63%。服用小麦纤维素期间无不良反应发生。结论：小麦纤维素治疗儿童功能性便秘疗效确切，安全性好。
Abstract
OBJECTIVE: To study the efficacy and safety of cellulose for the treatment of functional constipation in children. METHODS: A prospective, self-controlled, clinical trial using cellulose was conducted for 2 weeks in 34 children with functional constipation. The constipation symptoms and the characteristics of feces after the treatment were observed. RESULTS: The characteristics of feces and the constipation symptoms were improved significantly after the treatment. The total efficacy rate was 37% 3 days after treatment, 87% 7 days after treatment and 90% 14 days after treatment．The satisfactory rates of doctors and children′s parents on the therapeutic effects were 57% and 63%, respectively. No adverse events, such as abdominal distention, pain or diarrhea, were observed during the treatment. CONCLUSIONS: Cellulose is effective and safe in the treatment of functional constipation in children.
关键词
便秘 /
小麦纤维素 /
疗效 /
儿童
Key words
Functional constipation /
Cellulose /
Therapeutic effect /
Child
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参考文献
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